A method for establishing an animal model of damp-heat asthma

An animal model and method-building technology, applied in pharmaceutical formulations, compound screening/testing, and resistance to vector-borne diseases, etc., can solve the problems that cannot reflect the practical significance of the application of traditional Chinese medicine syndrome differentiation, cannot incorporate damp-heat factors, and cannot implement the thought of traditional Chinese medicine syndrome differentiation and treatment. Implementation and other issues, to achieve the effect of convenient research, high modeling success rate, and good model repeatability
CN104396880BInactive Publication Date: 2017-06-16季旭明
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
季旭明
Publication Date
2017-06-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a building method of a dampness-heat asthma animal model. The method comprises the following steps of using high-fat diet to feed a rat, filling colibacillosis, and forming a dampness-heat syndrome type of the rat; when the high-fat diet is fed, using albumen and aluminium hydroxide normal saline mixing suspension liquid to sensitize the rat; after sensitizing, activating by the albumen normal saline solution, so as to obtain the dampness-heat asthma animal model. The method has the advantage that the traditional asthma animal model is organically combined with the traditional Chinese dampness-heat syndrome type animal model to form the traditional Chinese dampness-heat syndrome type asthma animal model, so as to apply for the traditional Chinese clinical asthma study, and facilitate the study of traditional Chinese asthma relieving medicine sieving.
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Description

technical field

[0001] The invention relates to the technical field of animal pharmacological experiments, in particular to a method for establishing and detecting an animal model of damp-heat asthma. Background technique

[0002] The etiology and pathogenesis of allergic asthma is the type I allergic reaction caused by external antigens entering the body. The animal model prepared according to the basic principle that foreign antigens enter the body and cause type I allergy has become an important tool for researching the safety evaluation of antiasthmatic drugs and biological products and the screening of effective drugs. The occurrence of asthma is mostly due to chronic diseases lying in the lungs, which are triggered by exogenous factors, diet, emotion, fatigue and other inducements, resulting in phlegm blocking the airway and lung loss. However, due to changes in climate and dietary structure, people who eat fat, sweet, thick, greasy, spicy and fried food tend to accum...

Claims

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