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A kind of extraction method of aloin used in cosmetics

An extraction method and aloin technology, which are applied in the field of natural medicine extraction, can solve the problems of low product purity and low extraction yield, and achieve the effects of high extraction yield and good product purity.

Inactive Publication Date: 2016-08-24
JIANGSU QILIKANG SKIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problems of low extraction yield and low product purity in most of the extraction methods of aloin in the prior art, and propose an extraction method of aloin for cosmetics

Method used

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  • A kind of extraction method of aloin used in cosmetics

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for extracting aloin used in cosmetics, comprising the steps of:

[0026] Step 1, collect aloe vera leaves, after grinding, obtain the raw material slurry;

[0027] The 2nd step, prepare the phosphate buffer solution that the pH that contains mass concentration 1% composite enzyme is 3.5, and composite enzyme is cellulase;

[0028] Step 3: Mix the phosphate buffer solution and the raw material slurry evenly at a weight ratio of 15:1, heat to 35°C, and perform enzymolysis to obtain an enzymolysis solution;

[0029] Step 4, using a microfiltration membrane to filter and remove impurities from the enzymatic hydrolysis solution to obtain a microfiltration liquid;

[0030] The 5th step, adopt ultrafiltration membrane to filter microfiltration filtration, the molecular weight cut-off of the ultrafiltration membrane that adopts is 100000Da, obtains ultrafiltrate;

[0031] Step 6, sending the ultrafiltrate into the chromatographic column for impurity removal, the chr...

Embodiment 2

[0034] A method for extracting aloin used in cosmetics, comprising the steps of:

[0035] Step 1, collect aloe vera leaves, after grinding, obtain the raw material slurry;

[0036] The 2nd step, preparation is the phosphate buffer solution that the pH that contains mass concentration 4% compound enzyme is 4.5, and compound enzyme is cellulase;

[0037] Step 3. Mix the phosphate buffer solution and the raw material slurry evenly according to the weight ratio of 20:1, heat to 45°C, and perform enzymolysis to obtain an enzymolysis solution;

[0038] Step 4, using a microfiltration membrane to filter and remove impurities from the enzymatic hydrolysis solution to obtain a microfiltration liquid;

[0039] The 5th step, adopt ultrafiltration membrane to filter microfiltration filtration, the molecular weight cut-off of the ultrafiltration membrane that adopts is 100000Da, obtains ultrafiltrate;

[0040] Step 6, sending the ultrafiltrate into the chromatographic column for impurity...

Embodiment 3

[0043] A method for extracting aloin used in cosmetics, comprising the steps of:

[0044] Step 1, collect aloe vera leaves, after grinding, obtain the raw material slurry;

[0045] The 2nd step, prepare the phosphate buffer solution that the pH that contains mass concentration 2% composite enzyme is 4.0, and composite enzyme is cellulase;

[0046] Step 3, mix the phosphate buffer solution and the raw material slurry evenly according to the weight ratio of 17:1, heat to 40°C, and perform enzymolysis to obtain an enzymolysis solution;

[0047] Step 4, using a microfiltration membrane to filter and remove impurities from the enzymatic hydrolysis solution to obtain a microfiltration liquid;

[0048] The 5th step, adopt ultrafiltration membrane to filter microfiltration filtration, the molecular weight cut-off of the ultrafiltration membrane that adopts is 100000Da, obtains ultrafiltrate;

[0049] Step 6, sending the ultrafiltrate into the chromatographic column for impurity remo...

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Abstract

The invention relates to a method for extracting barbaloin used for cosmetic, which belongs to the technical field of crude drug extraction. The method comprises the following steps: collecting aloe leaf, grinding to obtain raw slurry, preparing a phosphate buffer solution containing compound enzyme; uniformly mixing the phosphate buffer solution and the raw slurry, heating , performing enzymatic hydrolysis to obtain a enzymatic hydrolysis liquid; employing a micro filter membrane for filtering and removing impurities of the enzymatic hydrolysis liquid to obtain a microfiltration clear liquid; employing an ultrafilter membrane for filtering the microfiltration filtering to obtain an ultrafiltration clear liquid; sending the ultrafiltration clear liquid in a chromatography column for removing impurities; performing spray drying on a permeation liquid of a chromatography column, sending powder to an extraction kettle, heating , introducing mixing fluid of an entrainer and CO2 gas, and extracting to obtain barbaloin. The extraction method has the advantages of high extraction yield and good products purity with more than 99%.

Description

technical field [0001] The invention relates to a method for extracting aloin used in cosmetics, and belongs to the technical field of natural medicine extraction. Background technique [0002] Aloe, commonly known as Aloe, originates in the Mediterranean Sea and Africa. It is a perennial herbaceous plant of the family Hennaceae. According to research, there are more than 300 wild aloe varieties, mainly distributed in Africa and other places. This plant is very popular among the public, mainly because it is easy to grow and is an ornamental plant with both flowers and leaves. There are only six kinds of edible varieties, and among them, the aloe varieties with medicinal value mainly include: Aloe vera (also known as Aloe vera of Barbados or Aloe vera), Aloe vera of Curacao (distributed in northern Africa and West Indies), Aloe vera of Cape of Good Hope ( Distributed in southern Africa), Yuanjiang aloe, etc. It can purify formaldehyde, sulfur dioxide, carbon monoxide and ot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D309/10
CPCC07D309/10
Inventor 吴克
Owner JIANGSU QILIKANG SKIN PHARMA