A kind of preparation method of compound micropill capsule and the prepared compound micropill capsule

A technology of teriflunomide compound pellets and capsules is applied in the preparation of compound pellets and capsules, and the field of compound pellets and capsules can solve the problems of inconvenience in taking, high production cost and high medical cost, and achieve convenient administration and low production and medical cost. , the effect of reducing irritation
CN104434904BInactive Publication Date: 2018-09-04HYBIO PHARMA
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HYBIO PHARMA
Publication Date
2018-09-04
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the technical field of medicine preparation, and discloses a preparation method for a compound pellet capsule and the prepared compound pellet capsule. The capsule structure comprises a medicine-carrying pill, a delayed-release layer and a rapid-release layer; the medicine-carrying pill is prepared by employing an extrusion-spheronization process; and the delayed-release layer and the rapid-release layer are prepared by employing a fluidized bed coating process. The prepared capsule is substantial in curative effect, safe, stable, convenient to take, small in side effect and low in production medical cost. The medicine effective compositions dimethyl fumarate and teriflunomide are different in drug action mechanism, also medicine administration is simple and convenient, and the curative effect of the two medicine effective compositions generates synergic effect, the indication scope is larger than that of a single medicine, multiple sclerosis is treated through multiple targets, and the curative effect is better than that of a single medicine.
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Description

technical field

[0001] The invention relates to the technical field of drug preparation, in particular to a preparation method of compound micropill capsules and compound micropill capsules prepared by the method. Background technique

[0002] Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelinating lesions of the central nervous system. Injuries that cause visual disturbances, loss of balance, poor coordination, slurred speech, tremors, numbness, extreme fatigue, intellectual changes, muscle weakness, paresthesias, and blindness account for more than 350,000 people with MS in the U.S. and about 2.5 million worldwide. Symptoms usually appear between the ages of 20 and 40, the number of female patients is twice that of males, and most patients are in the relapse period of the disease. There is no cure for the disease, only symptomatic treatment can reduce the relapse rate and disability rate of sclerosis to alleviate the suffering of patie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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