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Paederia scandens extract and application thereof

A kind of extract, the technology of vine vine, which is applied in the field of vine vine extract, can solve the problems of high energy consumption and cumbersome operation, and achieve the effect of high yield, low dosage and lower blood uric acid level

Active Publication Date: 2015-03-25
NINGBO DACHANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method disclosed in this application is cumbersome to operate and has high energy consumption.

Method used

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  • Paederia scandens extract and application thereof
  • Paederia scandens extract and application thereof
  • Paederia scandens extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 1.0kg of Yunnan medicinal materials (batch number: 131110), add 8 times the amount of 95% ethanol to reflux for extraction for 3 hours, extract 3 times, filter and combine the extracts, concentrate under reduced pressure at 60°C until there is no alcohol smell, add deionized water to 4L to make Dissolve, centrifuge, take D101 macroporous adsorption resin on the supernatant (1 kg of medicinal materials requires 300 ml of D101 resin pretreated by swelling with absolute ethanol), and the ratio of diameter to height of the resin column is 1:8. The flow rate is 1.0BV / h. After the sample is loaded, the elution flow rate is 5BV / h. First, use deionized water to elute 2BV of the resin column, discard the flow-through liquid and water eluent, and then use 85% ethanol to elute the resin Column 6BV, collect the eluate of 85% ethanol, concentrate under reduced pressure at 60°C, and dry to obtain 16.43g of the extract of Sagittarius japonica, batch number 131110, with a yield of ...

Embodiment 2

[0029] Take 1.0 kg of Yunnan medicinal materials (batch number: 131226), add 8 times the amount of 95% ethanol to reflux for extraction for 3 hours, extract 3 times, filter and combine the extracts, concentrate under reduced pressure at 60 ° C until there is no alcohol smell, add deionized water to 4 L Dissolve, centrifuge, take D101 macroporous adsorption resin on the supernatant (1 kg of medicinal materials requires 300 ml of D101 resin pretreated by swelling with absolute ethanol), and the ratio of diameter to height of the resin column is 1:8. The flow rate is 1.0BV / h. After the sample is loaded, the elution flow rate is 5BV / h. First, use deionized water to elute 2BV of the resin column, discard the flow-through liquid and water eluent, and then use 85% ethanol to elute the resin Column 6BV, collect the eluate of 85% ethanol, concentrate under reduced pressure at 60°C, and dry to obtain 15.79 g of sage rattan extract, batch number 131226, and the yield is 1.58%. The conten...

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Abstract

The invention discloses a paederia scandens extract. The extract contains iridoid glycoside compounds, and is characterized in that the iridoid glycoside compounds are mainly composed of 20.0-50.0% of paederosidic acid, 2.0-25.0% of paederoside and 1.0-10.0% of paederosidic acid methyl ester. The paederia scandens extract is prepared by the following ways: a) extracting paederia scandens medicinal material by virtue of ethanol to obtain an extracting solution; b) concentrating the extracting solution until no alcohol smell exists, carrying out macro-porous adsorption resin chromatography, eluting with water and 80-90% of ethanol sequentially, collecting eluate, and drying the eluate under reduced pressure to obtain the paederia scandens extract. The paederia scandens extract disclosed by the invention is applicable to the preparation of medicines which are capable of reducing uric acid, and also resisting inflammation and gouty arthritis.

Description

technical field [0001] The present invention relates to an extract of vine vine and its use. Background technique [0002] Chicken Yateng is the above-ground part or whole plant of Rubiaceae Paederia scandens (Lour.) Merr. It is a traditional Chinese herbal medicine, also known as chicken shit rattan, cowhide jelly, Jieshu rattan, bullshit rattan, smelly rattan, breeze Rattan, etc., Cercis japonica tastes glucoside, flat in nature, enters the liver, stomach, and large intestine meridians, and has the effects of eliminating food accumulation, dispelling wind and activating blood circulation, relieving pain and reducing swelling. Distributed in many countries in China and Southeast Asia, domestic and foreign studies on the pharmacological effects and clinical application of Gallus vine mainly focus on anti-inflammatory, analgesic and treatment of digestive system diseases. In recent years, the chemical composition studies have shown that Sagittaria mainly contains sulfur-cont...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P19/06A61P19/02A61P29/00
CPCA61K36/74A61K2236/33A61K2236/333A61K2236/51
Inventor 吴彤沈幸光沈龙海周海凤李默影乐心逸张乐乐颜仁杰张雪张美璇王娴娴刘艺
Owner NINGBO DACHANG PHARMA
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