Preparation method of mesoporous beta-TCP (tricalcium phosphate) powder

Abstract

The invention relates to a preparation method of mesoporous beta-TCP (tricalcium phosphate) powder. The preparation method comprises steps as follows: 1), two parts of transparent solutions containing surfactants, cosurfactants and water are prepared; 2), a calcium-containing inorganic salt solution and a phosphorus-containing inorganic salt solution are added to the transparent solutions respectively and stirred, a phosphorus-containing inorganic salt mixed solution is added to a calcium-containing inorganic salt mixed solution, the pH value is adjusted, and the mixture is stirred to obtain an emulsion; and 3), the mixture is left to stand, subjected to ageing, centrifugation, washing and drying, placed in a high-temperature furnace, heated and subjected to heat preservation, and mesoporous beta-TCP powder is obtained. The preparation method has the benefits as follows: 1, the operation is simple, energy consumption is low, the cost is low, the reaction condition is mild, and harmful substances are not generated in the preparation process; and 2, the obtained mesoporous beta-TCP powder has smaller pore diameter and has a three-dimensional pore structure, the average pore diameter of the mesoporous beta-TCP powder is 8.80-21.36 nm, and the specific surface area is 10.11-153.43 m<2> / g.

Description

technical field

[0001] The invention relates to a preparation method of mesoporous β-tricalcium phosphate powder. Background technique

[0002] Ca 3 (PO 4 ) 2 [TCP] There are two types of high-temperature α-phase and low-temperature β-phase. Among them, the low-temperature type β-TCP[β-Ca 3 (PO 4 ) 2 ] is mainly composed of calcium and phosphorus, and its composition is similar to that of the inorganic components of the bone matrix [Ca 10 (PO 4 ) 6 (OH) 2 ] similar, with good biocompatibility. Scholars have confirmed that β-TCP can be absorbed by the body without inflammation or rejection, and without local or systemic toxicity. The degree of hemolysis of β-TCP is less than 5%; it is classified as non-toxic according to the measurement of toxicity; β-TCP can be directly combined with bone tissue without fibrous tissue growing in between. After β-TCP is implanted into bone tissue, a solid-liquid balance of calcium and phosphorus is formed at the interface. The i...

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