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Preparation method of mesoporous beta-TCP (tricalcium phosphate) powder

A tricalcium phosphate powder and mesoporous technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of mesoporous β-TCP crystal habit and preparation difficulties, and achieve continuously adjustable pore size, high Effect of low specific surface area and cost

Active Publication Date: 2015-03-25
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mesoporous β-TCP has not been reported due to its crystal habit and difficulty in preparation.

Method used

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  • Preparation method of mesoporous beta-TCP (tricalcium phosphate) powder
  • Preparation method of mesoporous beta-TCP (tricalcium phosphate) powder
  • Preparation method of mesoporous beta-TCP (tricalcium phosphate) powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prepare two transparent solutions containing surfactant CTAB, co-surfactant n-butanol and water, wherein the volume of water is 40 mL, the concentration of surfactant is 12.5 g / L, and the concentration of co-surfactant is 100 mL / L, and then to Add 0.5mol / L Ca(NO 3 ) 2 4H 2 O solution 20mL and 0.5mol / L (NH 4 ) 2 HPO 4 solution, and fully stirred at 40°C to obtain a mixed solution of calcium-containing inorganic salts and a mixed solution of phosphorus-containing inorganic salts. Keeping the temperature constant, add phosphorus-containing A mixed solution of inorganic salts, and the molar ratio of the added element calcium to phosphorus is 1.5:1, with NH 3 ·H 2 O solution to adjust the pH to 7.5, continue magnetic stirring for 21 hours, then stand at room temperature for 48 hours, centrifuge at 10,000 rpm for 3 minutes, wash the precipitate with water three times, then wash it with alcohol three times, and finally put the precipitate in a drying box After drying at...

Embodiment 2

[0026] Prepare two clear solutions containing the surfactant polyethylene glycol 6000, the co-surfactant 1-octanol, and water, where the volume of water is 30 mL, the concentration of surfactant is 10 g / L, and the concentration of co-surfactant is 50 mL / L. L, then add 0.1mol / L CaCl to the two transparent solutions 2 Solution 30mL and 0.1mol / L NaH 2 PO 4solution, and fully stirred at 25°C to obtain a mixed solution of calcium-containing inorganic salts and a mixed solution of phosphorus-containing inorganic salts. Keep the temperature constant, add the mixed solution of phosphorus-containing inorganic salt to the mixed solution of calcium-containing inorganic salt at a speed of 0.2mL per minute, and make the molar ratio of the added element calcium to phosphorus be 1.5:1, and use NH 3 ·H 2 The pH of the O solution was adjusted to 6.0, and magnetic stirring was continued for 2 hours, then left to age at room temperature for 12 hours, centrifuged at 9500 rpm for 3 minutes, and...

Embodiment 3

[0028] Prepare two transparent solutions containing surfactant polyoxyethylene-polyoxypropylene-polyoxyethylene, co-surfactant n-propanol and water, wherein the volume of water is 200mL, the concentration of surfactant is 100g / L, co-surfactant The agent concentration was 250mL / L, and then 1.0mol / L of CaSO was added to the two transparent solutions 4 Solution 80mL and 1.0mol / L Na 3 PO 4 solution, and fully stirred at 90°C to obtain a mixed solution of calcium-containing inorganic salts and a mixed solution of phosphorus-containing inorganic salts. Keep the temperature constant, add the mixed solution of phosphorus-containing inorganic salt to the mixed solution of calcium-containing inorganic salt at a rate of 0.6mL per minute, and make the molar ratio of the added element calcium to phosphorus 1.5:1, use NH 3 ·H 2 The pH of the O solution was adjusted to 9.0, and the magnetic stirring was continued for 24 hours, then left to age at room temperature for 24 hours, centrifuged...

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Abstract

The invention relates to a preparation method of mesoporous beta-TCP (tricalcium phosphate) powder. The preparation method comprises steps as follows: 1), two parts of transparent solutions containing surfactants, cosurfactants and water are prepared; 2), a calcium-containing inorganic salt solution and a phosphorus-containing inorganic salt solution are added to the transparent solutions respectively and stirred, a phosphorus-containing inorganic salt mixed solution is added to a calcium-containing inorganic salt mixed solution, the pH value is adjusted, and the mixture is stirred to obtain an emulsion; and 3), the mixture is left to stand, subjected to ageing, centrifugation, washing and drying, placed in a high-temperature furnace, heated and subjected to heat preservation, and mesoporous beta-TCP powder is obtained. The preparation method has the benefits as follows: 1, the operation is simple, energy consumption is low, the cost is low, the reaction condition is mild, and harmful substances are not generated in the preparation process; and 2, the obtained mesoporous beta-TCP powder has smaller pore diameter and has a three-dimensional pore structure, the average pore diameter of the mesoporous beta-TCP powder is 8.80-21.36 nm, and the specific surface area is 10.11-153.43 m<2> / g.

Description

technical field [0001] The invention relates to a preparation method of mesoporous β-tricalcium phosphate powder. Background technique [0002] Ca 3 (PO 4 ) 2 [TCP] There are two types of high-temperature α-phase and low-temperature β-phase. Among them, the low-temperature type β-TCP[β-Ca 3 (PO 4 ) 2 ] is mainly composed of calcium and phosphorus, and its composition is similar to that of the inorganic components of the bone matrix [Ca 10 (PO 4 ) 6 (OH) 2 ] similar, with good biocompatibility. Scholars have confirmed that β-TCP can be absorbed by the body without inflammation or rejection, and without local or systemic toxicity. The degree of hemolysis of β-TCP is less than 5%; it is classified as non-toxic according to the measurement of toxicity; β-TCP can be directly combined with bone tissue without fibrous tissue growing in between. After β-TCP is implanted into bone tissue, a solid-liquid balance of calcium and phosphorus is formed at the interface. The i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 戴红莲黄岸喻莹韩颖超李世普
Owner WUHAN UNIV OF TECH
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