A serum creatinine detection reagent

A technology for detecting reagents and serum creatinine, which is applied in biological tests, measuring devices, material inspection products, etc., can solve the problems of unsatisfactory detection effect, weak anti-interference ability, low precision and accuracy, etc. Strong anti-interference ability and sensitivity, the effect of high analytical sensitivity
CN104459164BActive Publication Date: 2016-03-23BIOBASE BIODUSTRY (SHANDONG) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BIOBASE BIODUSTRY (SHANDONG) CO LTD
Publication Date
2016-03-23

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Abstract

The invention discloses a serum creatinine detecting reagent, and belongs to the technical field of clinical in-vitro detection. According to the serum creatinine detecting reagent, gamma-Fe2O3 nano-particles are added into a reagent R1, so that the activity of peroxidase and the specificity to a substrate are enhanced, and the interferences of reducing substances, such as ascorbic acid, uric acid, glutathione and bilirubin, are reduced; meanwhile, the gamma-Fe2O3 nano-particles also serve as a catalyst of a reaction; the interference of endogenous creatine is effectively eliminated by the combination action of the gamma-Fe2O3 nano-particles and the peroxidase. In addition, the serum creatinine detecting reagent adopts N-ethyl-N-(2-hydroxy-3-sulfonated propyl)-3-methylaniline sodium salt (TOOS) as a chromogen, so that the reagent is more stable; the analysis sensitivity is high. The substances, such as lipase and lipoprotein lipase, are also added into the reagent R1, so that the influence of lipid turbidity can be removed effectively; therefore, the reagent of the invention has higher anti-jamming capability and stability.
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Description

technical field

[0001] The invention relates to a detection reagent for clinical determination of creatinine content in serum, belonging to the technical field of clinical in vitro detection. Background technique

[0002] Serum creatinine (Cr), also known as blood creatinine, is generally considered to be endogenous blood creatinine, which is a product of human muscle metabolism. In muscle, creatine is mainly slowly formed into creatinine through irreversible non-enzymatic dehydration reaction, and then released into the blood and excreted with urine. Therefore, serum creatinine is closely related to the total amount of muscle in the body and is not easily affected by diet. Creatinine is a small molecular substance that can be filtered by the kidneys and is rarely absorbed in the renal tubules. Almost all creatinine produced in the body is excreted with urine and is generally not affected by urine output. Serum creatinine detection is one of the main methods commonly used ...

Claims

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