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Zinc and cobalt metal complex taking nantenine oxide as ligand as well as synthetic method and application thereof

A technology of Nandina and a synthesis method, applied in the fields of cobalt metal complexes and their synthesis, and zinc, can solve problems such as unseen and blank research reports, and achieve the effects of good medicinal value and strong anti-tumor activity.

Inactive Publication Date: 2015-04-01
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But up to now, there is no research report on the zinc and cobalt metal complexes with nanandine as the ligand, and the research reports on the zinc and cobalt metal complexes are also blank.

Method used

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  • Zinc and cobalt metal complex taking nantenine oxide as ligand as well as synthetic method and application thereof
  • Zinc and cobalt metal complex taking nantenine oxide as ligand as well as synthetic method and application thereof
  • Zinc and cobalt metal complex taking nantenine oxide as ligand as well as synthetic method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Synthesis of ONT-Zn (Ⅱ) complexes with normal pressure solution method

[0038] 1mmol Zn(NO 3 ) 2 .6H 2 O and 2mmol of ONT were dissolved in 20mL of methanol solution, and reacted at 65°C (reflux) for 10h, the solution gradually changed from yellow to reddish brown, and a large amount of complex solids were formed; after cooling and filtering the solution, followed by water , washing and filtering the obtained solid with ethanol, and drying to finally obtain a red solid product, yield: 67%. The product is subjected to infrared spectroscopy (the spectrogram is as figure 1 shown), electrospray mass spectrometry (spectrum as shown in figure 2 shown) and X-ray single crystal diffraction analysis (spectrum as image 3 Shown) for structure determination, identified as the target complex [Zn(ONT) 2 (CH 3 OH)(NO 3 )] NO 3 .

Embodiment 2

[0039] Example 2: Synthesis of ONT-Co(II) complexes by normal pressure solution method

[0040] 1mmol Co(ClO 4 ) 2 .6H2 O and 2 mmol of ONT were dissolved in 40 mL of a mixed solution of ethanol and dimethyl sulfoxide (volume ratio 4:5), and reacted at 80°C (reflux for condensation) for 24 hours. After the reaction, a red suspension was obtained with a large amount of The complex solid was formed; the solution was filtered, the filtered solid was washed with water and ethanol in turn, and dried to finally obtain a red solid product with a yield of 71%. The product is subjected to infrared spectroscopy (the spectrogram is as Figure 4 shown), electrospray mass spectrometry (spectrum as shown in Figure 5 shown) and X-ray single crystal diffraction analysis (spectrum as Image 6 Shown) for structure determination, identified as the target complex [Co(ONT) 2 (H 2 O) 2 ](ClO 4 ) 2 .

Embodiment 3

[0041] Embodiment 3: Synthesis of ONT-Zn (Ⅱ) complex with solvothermal method

[0042] Weigh 0.1mmol Zn(NO 3 ) 2 .6H 2 O and 0.2 mmol ONT were placed in a thick-walled borosilicate glass tube with an open end, and then 1.5 mL of a mixed solvent of ethanol and water (volume ratio 1:2) was added. Melting and sealing, and then fully reacting at 110°C for 12 hours, a red crystalline solid product can be obtained, with a yield of 53%. The product was determined to be the target complex [Zn(ONT) 2 (CH 3 OH)(NO 3 )] NO 3 .

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Abstract

The invention discloses a zinc and cobalt metal complex taking nantenine oxide as a ligand as well as a synthetic method and application thereof. The synthetic method of the zinc and cobalt metal complex comprises the following step: by taking nantenine oxide as the ligand, performing coordination reaction with metal salts in a polar solvent to obtain the zinc and cobalt metal complex; and specifically, the zinc and cobalt metal complex can be synthesized by virtue of a solution process, and can also be synthesized by virtue of a solvothermal process. Results obtained by investigating the inhibition effects of the zinc and cobalt metal complex on various tumor cell strains by the applicants show that the zinc and cobalt complex plays stronger anti-tumor activity than the nantenine oxide ligand, has the anti-tumor activity on part of tumor strains significantly superior to that of cis-platinum namely a clinical anti-cancer medicine, and has relatively good potential medicinal values. A structural general formula of the zinc and cobalt metal complex is shown in the specification, wherein M represents a bivalent metal cation namely Zn(II) or Co(II); L represents water or methanol; and X represents an anion of a metal salt obtained when the metal cation participates in reaction in a metal salt form, and is a nitrate radical or a perchlorate radical.

Description

technical field [0001] The invention relates to the field of metal coordination compounds, in particular to a zinc and cobalt metal complex with nantianaine oxide as a ligand and a synthesis method and application thereof. Background technique [0002] Oxidized nanthrophylline is a typical oxidized aporphine alkaloid, which widely exists in traditional Chinese medicine plants such as Magnoliaceae, Anemoneaceae, Papaveraceae, Fanghekeceae, etc., and can be obtained by extraction and separation from these plants (Stuan Yun, Hopakine-like alkaloids in the aerial part of Fangji, Journal of Jining Medical College, Volume 14, Issue 2, June 1991). Oxyaporphine is a series of alkaloids with significant pharmacological activity. Oxidized aporphine has stronger physiological activity than aporphine alkaloids due to its special rigid plane, heterocyclic N atom and carbonyl oxygen (C=O) group. [0003] On the other hand, with the continuous improvement of people's understanding of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F3/06C07F15/06A61K31/555A61P35/00
CPCC07F3/06C07F15/065
Inventor 梁宏陈振锋刘延成王雅颂张业黄克斌
Owner GUANGXI NORMAL UNIV
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