Anti-HPV (human papillomavirus) gel dressing and preparation method thereof

Abstract

The invention discloses an anti-HPV (human papillomavirus) gel dressing and a preparation method thereof and particularly relates to application of anti-HPV gel dressing in prevention and treatment of HPV infection and other diseases. The anti-HPV gel dressing mainly comprises anti-HPV freeze-dried powder and a dissolving solution, wherein the anti-HPV freeze-dried powder comprises the following components: tea acidic protein AP, isomaltooligosacharide, a freeze-drying protective additive and a bactericide / fungistat; the dissolving solution comprises the following components: water, phosphate, glycerin and mint oil. The anti-HPV gel dressing prepared by virtue of the preparation method is not greasy, can absorb tissue percolate, does not easily flow out and impede the normal functions of mucous membranes, can be used for effectively treating genital virus infection and preventing cervical cancer and penile cancer and has remarkable treatment effects to the diseases such as cervical intraepithelial neoplasia (CIN) and chronic cervicitis caused by virus infection.

Description

technical field [0001] The invention relates to the field of medicine, more specifically, relates to an anti-HPV virus gel dressing and a preparation method thereof, as well as its application in treating and preventing genital virus infection, chronic cervicitis, cervical cancer, penile cancer and other HPV-related diseases. Background technique [0002] In my country, the new incidence of cervical cancer accounts for 73-93% of the incidence of malignant tumors of the female reproductive system, which is 6 times that of developed countries. It is most common among women aged 25 to 45, and some regions are 10% higher than the national average. times. Dr. Harald Zurhausen, winner of the Nobel Prize in Physiology and Medicine in 2008, discovered that HPV (Human Papillomavirus, HPV) is the cause of cervical cancer. In the medical insurance of developed countries such as the United States, it has been clearly stipulated that women should undergo cervical smear cytology examinati...

AI Technical Summary

Problems solved by technology

[0004] At present, the drug treatment of gynecological diseases is mainly administered through the vagina, and the dosage forms of the commonly used vaginal preparations mainly include suppositories, gels, effervescent tablets, vaginal tablets, lotions, capsules, films, etc., but these dosage forms or more Or there are some defects that affect the function of the drug

[0005] Such as ① lotion, the action time is short, it is difficult to penetrate deep into the cavity, it is difficult to fully reach the disease site, and the drug is not easy to fully exert its effect, and the drug used to treat cervical erosion should not be made into a lotion

[0006] ② Vaginal tablets, ordinary vaginal tablets have poor distribution, and the contact surface with the mucous membrane is small, so it is not suitable to penetrate into the folds; vaginal effervescent tablets need the cooperation of vaginal mucus, so they are not suitable for patients with vaginitis sicca

Moreover, suppositories are easily deformed when the temperature is high, and the stability is not good.

[0008] ④ Capsules, the drug is not easy to release, the coating surface is poor, affected by the disintegration of the capsule

[0009] ⑤ Vaginal film, the contact surface between the drug and the mucous membrane is small, and the permeability is poor, so it is not suitable for women with less vaginal secretions

[0010] ⑥ For vaginal gels, the drug coating surface and permeability are not enough, and the stability is not good

[0011] ⑦ Sprays are not easy to reach the depth of the cavity, so they are rarely used in vaginal administration

Spray medicine is difficult to evenly distribute to the vaginal wall, and it is difficult to fully exert the drug effect

When treating cervical erosion, spray medication also has the disadvantage of being difficult to reach the medication site

[0012] ⑧Foam aerosol, the cost is relatively high (due to the need for internal pressure containers, valve systems and special production equipment), the cooling effect of the propellant can cause wound discomfort and irritation

[0013] ⑨Squeeze the liquid, the drug is easy to flow out when standing

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