Anti-HPV (human papillomavirus) gel dressing and preparation method thereof

An HPV virus and gel technology, which is applied in the field of medicine, can solve the problems of not being easy to penetrate deep into the cavity, affecting the effect of drugs, and poor stability, and achieving the treatment of HPV virus infection, good clinical application prospects, and direct drug effects. Effect

Active Publication Date: 2015-04-08
海南森瑞谱生命科学药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drug treatment of gynecological diseases is mainly administered through the vagina, and the dosage forms of the commonly used vaginal preparations mainly include suppositories, gels, effervescent tablets, vaginal tablets, lotions, capsules, films, etc., but these dosage forms or more Or there are some defects that affect the function of the drug
[0005] Such as ① lotion, the action time is short, it is difficult to penetrate deep into the cavity, it is difficult to fully reach the disease site, and the drug is not easy to fully exert its effect, and the drug used to treat cervical erosion should not be made into a lotion
[0006] ② Vaginal tablets, ordinary vaginal tablets have poor distribution, and the contact surface with the mucous membrane is small, so it is not suitable to penetrate into the folds; vaginal effervescent tablets need the cooperation of vaginal mucus, so they are not suitable for patients with vaginitis sicca
Moreover, suppositories are easily deformed when the temperature is high, and the stability is not good.
[0008

Method used

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  • Anti-HPV (human papillomavirus) gel dressing and preparation method thereof
  • Anti-HPV (human papillomavirus) gel dressing and preparation method thereof
  • Anti-HPV (human papillomavirus) gel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of tea acidic protein AP

[0044] Take fresh tea leaves from Wuzhi Mountain in Hainan, grind and homogenize them with a material-water ratio of 1:5 (w / v), adjust the pH to 7-9, extract at 40°C for 3 hours, filter and centrifuge, take the supernatant, adjust the pH to 2-5, centrifuge, and take the precipitate , and the crude product of tea acidic protein AP was obtained after freeze-drying. After the crude tea acidic protein AP is reconstituted, it passes through a CM Sepharose Fast Flow chromatography column to remove the basic protein, collects the flow-through solution containing the acidic protein, and vacuum freeze-dries it to make the tea acidic protein AP.

[0045] 2. Preparation of anti-HPV virus freeze-dried powder:

[0046]Add 0.01 part of tea acid protein AP, 10 parts of maltose isopolysaccharide, 89.94 parts of polysaccharide, and 0.05 part of chlorhexidine, add water to dissolve, stir evenly, and dry in vacuum at low temperature.

[0047] 3....

Embodiment 2

[0056] 1. Preparation of tea acidic protein AP

[0057] Take fresh tea leaves from Wuzhi Mountain in Hainan, grind and homogenize them with a material-water ratio of 1:8 (w / v), adjust the pH to 7-9, extract at 25°C for 3 hours, filter and centrifuge, take the supernatant, adjust the pH to 2-5, centrifuge, and take the precipitate , and the crude product of tea acidic protein AP was obtained after freeze-drying. After the crude tea acidic protein AP is reconstituted, it passes through a CM Sepharose Fast Flow chromatography column to remove the basic protein, collects the flow-through solution containing the acidic protein, and vacuum freeze-dries it to make the tea acidic protein AP.

[0058] 2. Preparation of anti-HPV virus freeze-dried powder:

[0059] Add 1 part of tea acid protein AP, 15 parts of maltose, 83.99 parts of polysaccharide, and 0.01 part of chlorhexidine, dissolve in water, stir evenly, and dry in vacuum at low temperature.

[0060] 3. Preparation of solution...

Embodiment 3

[0069] 1. Preparation of tea acidic protein AP

[0070] Take fresh tea leaves from Wuzhi Mountain in Hainan, grind and homogenize them with a material-water ratio of 1:10 (w / v), adjust the pH to 7-9, extract at 10°C for 3 hours, filter and centrifuge, take the supernatant, adjust the pH to 2-5, centrifuge, and take the precipitate , and the crude product of tea acidic protein AP was obtained after freeze-drying. After the crude tea acidic protein AP is reconstituted, it passes through a CM Sepharose Fast Flow chromatography column to remove the basic protein, collects the flow-through solution containing the acidic protein, and vacuum freeze-dries it to make the tea acidic protein AP.

[0071] 2. Preparation of anti-HPV virus freeze-dried powder:

[0072] Add 5 parts of tea acid protein AP, 25 parts of maltose, 69.98 parts of polysaccharide, and 0.02 part of chlorhexidine, add water to dissolve, stir evenly, and dry in vacuum at low temperature.

[0073] 3. Preparation of so...

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Abstract

The invention discloses an anti-HPV (human papillomavirus) gel dressing and a preparation method thereof and particularly relates to application of anti-HPV gel dressing in prevention and treatment of HPV infection and other diseases. The anti-HPV gel dressing mainly comprises anti-HPV freeze-dried powder and a dissolving solution, wherein the anti-HPV freeze-dried powder comprises the following components: tea acidic protein AP, isomaltooligosacharide, a freeze-drying protective additive and a bactericide/fungistat; the dissolving solution comprises the following components: water, phosphate, glycerin and mint oil. The anti-HPV gel dressing prepared by virtue of the preparation method is not greasy, can absorb tissue percolate, does not easily flow out and impede the normal functions of mucous membranes, can be used for effectively treating genital virus infection and preventing cervical cancer and penile cancer and has remarkable treatment effects to the diseases such as cervical intraepithelial neoplasia (CIN) and chronic cervicitis caused by virus infection.

Description

technical field [0001] The invention relates to the field of medicine, more specifically, relates to an anti-HPV virus gel dressing and a preparation method thereof, as well as its application in treating and preventing genital virus infection, chronic cervicitis, cervical cancer, penile cancer and other HPV-related diseases. Background technique [0002] In my country, the new incidence of cervical cancer accounts for 73-93% of the incidence of malignant tumors of the female reproductive system, which is 6 times that of developed countries. It is most common among women aged 25 to 45, and some regions are 10% higher than the national average. times. Dr. Harald Zurhausen, winner of the Nobel Prize in Physiology and Medicine in 2008, discovered that HPV (Human Papillomavirus, HPV) is the cause of cervical cancer. In the medical insurance of developed countries such as the United States, it has been clearly stipulated that women should undergo cervical smear cytology examinati...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61K9/06A61K9/19A61P31/20A61P15/00A61P35/00
Inventor 张春发邓柳红高海波唐权黄超陈一萍王胜王桂玉
Owner 海南森瑞谱生命科学药业股份有限公司
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