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A liquid-drop-generation capillary microfluidic chip and a preparing method thereof

A microfluidic chip, capillary technology, applied in chemical instruments and methods, laboratory utensils, laboratory containers, etc., to achieve the effect of efficient preparation and collection of tools

Inactive Publication Date: 2015-04-15
王来 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, the capillary is inserted into the intersection of oil and water, so that the droplets generated on the microfluidic chip directly enter the capillary, which solves the problem of fusion of droplets caused by dead volume and the contradiction between the size of the traditional capillary and the size of the main channel

Method used

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  • A liquid-drop-generation capillary microfluidic chip and a preparing method thereof
  • A liquid-drop-generation capillary microfluidic chip and a preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] see figure 1 , the preparation steps of the water-in-oil droplet capillary microfluidic chip are as follows:

[0029] 1. Fabrication of the mask: first design and draw the microstructure and microchannel graphics of the droplet-generating capillary microfluidic chip with the design software (AutoCAD), and print the graphics into a mask, and use the mask to make a silicon wafer mold;

[0030] 2. Silicon wafer mold making: first clean the silicon wafer, and use concentrated H 2 SO 4 / H 2 o 2 =3:1, soak for 15min, then clean the wafer with absolute ethanol, acetone, and ultrapure water; dry the wafer on a heating plate; modify the wafer with hexamethyldisilazane, pour the photoresist AZ-50XT, drop glue at 2000rpm for 1min15s, then carry out pre-baking polymerization; place the mask and silicon wafer in the corresponding position of the photolithography machine, UV exposure, and finally develop;

[0031] 3. Fabrication of PDMS chips: use the prepared silicon wafer mold...

Embodiment 2

[0038] The preparation steps of capillary microfluidic chip for oil-in-water droplet generation are as follows:

[0039]1. Fabrication of the mask: first design and draw the microstructure and microchannel graphics of the droplet-generating capillary microfluidic chip with the design software (AutoCAD), and print the graphics into a mask, and use the mask to make a silicon wafer mold;

[0040] 2. Cleaning of glass substrate: use concentrated H 2 SO 4 / H 2 o 2 = 3:1, soak for 15min, then clean the wafer with absolute ethanol, acetone, and ultrapure water, and dry it on a heating plate;

[0041] 3. Sacrificial layer sputtering: Sputter a chromium layer with a thickness of 145nm on the surface of the cleaned glass substrate with an ion sputtering device;

[0042] 4. Pre-treatment of photolithography: After modifying the glass substrate with hexamethyldisilazane on the chromium plate glass, pour the photoresist AZ-4620, drop the glue at 3000rpm for 1min, and then carry out pre...

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Abstract

The invention relates to a liquid-drop-generation capillary microfluidic chip and a preparing method thereof. The liquid-drop-generation capillary microfluidic chip adopts a capillary as a function unit for generating and collecting liquid drops, and comprises a microfluidic chip etched with microchannels and the capillary. By combination of the microfluidic chip and the capillary, the liquid-drop-generation capillary microfluidic chip achieves introduction of two incompatible liquids on the microfluidic chip, achieves liquid drop generation at the intersection of the microfluidic chip and the capillary, and directly collects liquid drops in the capillary. The liquid-drop-generation capillary microfluidic chip is simple in structure and convenient to operate, overcomes the problem that liquid uniformity and the like are liable to damage in traditional liquid drop collection-generation and collection methods, and achieves integration of liquid drop generation and capillary collection.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chips, and in particular relates to a capillary microfluidic chip for generating droplets and a preparation method thereof. Background technique [0002] Microfluidic chip (Microfluidic chip), also known as lab on a chip (Lab on a chip) or microfluidic chip laboratory is the hot field of μTAS development at present, and the application of microfluidic chip technology in medicine, life science and other fields has been greatly Constantly expanding. A microfluidic chip refers to the construction of a chemical or biological laboratory on a chip of a few square centimeters, which can integrate sample preparation, reaction, detection, cell culture, sorting, and lysis in the fields of chemistry and biology involved. The basic operation units such as integrated into this very small chip are used to complete different biological and chemical reaction processes, and through the network formed by micr...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 王来沙俊
Owner 王来
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