Extraction process for large-scale production of radix angelicae extract in medicinal radix angelicae material

Abstract

The invention relates to an extraction process for large-scale production of a radix angelicae extract in a medicinal radix angelicae material. The extraction process is characterized by comprising the following steps: for primary refluxing, adding 10 parts by weight of coarse radix angelicae powder into an extraction tank; adding 40-50 parts by weight of 75% to 85% ethanol into the extraction tank; heating to the temperature of 60 DEG C; soaking for 1-1.5 hours and then stopping heating; soaking for 3 hours; heating again, controlling the temperature to be 75 to 78 DEG C and performing reflux extraction for 1 hour; for secondary refluxing, adding 40-50 parts by weight of 75% to 85% ethanol into the extraction tank, soaking for 1-1.5 hours at normal temperature, heating again, controlling the temperature to be 75 to 78 DEG C and performing reflux extraction for 1 hour; combining the two extraction solutions, decompressing and concentrating; discharging when the relative density of a radix angelicae extract is equal to 1.10 to 1.40. The extraction process is short in production period, high in production efficiency, low in production cost, complete in extraction, good in environmental protection property and high in safety coefficient. According to the process, reflux extraction is performed twice; the production period is 1.8 day / batch; the extraction rate is 15% to 20%; the extract yield is relatively smaller than that of a percolation process; the content of effective components in the extract is higher; the transfer rate of the effective components of the extract is above 70% based on imperatorin.

Description

technical field [0001] The invention relates to a process for extracting effective components of traditional Chinese medicines, in particular to a process for extracting an extract of Angelica dahurica from medicinal materials of Angelica dahurica. Background technique [0002] Some solid medicaments prepared with imperatorin, an extract of Angelica dahurica as the active ingredient, plus auxiliary materials or auxiliary ingredients, have a good effect on the treatment of migraine, tension and nervous headaches. At present, the percolation process is generally used in the large-scale production of the extraction of Angelica dahurica medicinal materials. The extraction cycle of each batch of the percolation process is 4.5 days. The production cycle is long, the production efficiency is low, and the production cost is also high. Moreover, the extraction is not complete enough, and the extracted medicinal residues still contain active ingredients. And because the paste output ...

AI Technical Summary

Problems solved by technology

At present, the percolation process is generally used in the large-scale production of the extraction of Angelica dahurica medicinal materials. The extraction cycle of each batch of percolation process is 4.5 days, the production cycle is long, the production efficiency is low, and the production cost is also high.

Moreover, the extraction is not complete enough, and the extracted dregs still contain active ingredients

And because the amount of paste is large and the content of active ingredients is low, it is not convenient to feed and use solid preparations.

The solvent used in the percolation process involves not only water and ethanol, but also other organic solvents such as chloroform, petroleum ether, acetone, etc., which will not only pollute the air environment and production environment, but also bring poison to the operators. Environmental protection Relatively poor

Although there is also a production process that adopts reflux to extract Angelica dahurica at present, this process is not suitable for large-scale production. The volatility coefficient of 95% ethanol solution used in this process is relatively high, and the ethanol concentration in the air of the production operation environment is relatively high, so the safety factor lower

Images