External preparation for treating facial seborrheic dermatitis

A technology for seborrheic dermatitis and external preparations, applied in the directions of medical preparations containing active ingredients, anti-inflammatory agents, topical antibacterial agents, etc., can solve the problems of low effective rate, easy recurrence of symptoms, etc. Inflammatory response and the effect of repairing epidermal barrier function

Active Publication Date: 2015-04-29
大连亚维药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment methods for facial seborrheic dermatitis include simple anti-inflammatory drugs (such as hormone topical preparations, calcineurin inhibitors), supplemented with skin moisturizing and skin care products, and the efficiency is low; and symptoms tend to recur after drug withdrawal

Method used

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  • External preparation for treating facial seborrheic dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Add 6.2g glycerol and 10g triethanolamine into boiled 55ml distilled water, stir to dissolve, cool and keep the temperature at 80-85°C as the water phase; add 12.4g stearic acid, 12.4g castor oil and Heat and melt 12.4g of liquid paraffin, keep the temperature at 80-85°C, as the oil phase; add the above-mentioned oil phase to the above-mentioned water phase under slow stirring to complete the matrix preparation; when the matrix is ​​cooled to 50-60°C, add the drug Add 0.05g of chlorhexidine acetate, 0.05g of ketoconazole, 0.05g of ceramide, 8g of glycerol, and 0.8g of glycyrrhizin into the aforementioned base, stir evenly in the same direction, and cool to room temperature.

Embodiment 2

[0021] Embodiment 2: 6.2g glycerin and 10g triethanolamine are added into boiled 55ml distilled water, stir to dissolve, cool and keep the temperature at 80-85°C, as the water phase; 12.4g stearic acid, 12.4g castor oil and Heat and melt 12.4g of liquid paraffin, keep the temperature at 80-85°C, and use it as the oil phase; add the aforementioned water phase to the aforementioned oil phase under slow stirring to complete the matrix preparation; when the matrix is ​​cooled to 50-60°C, add the drug Add 0.08g of chlorhexidine acetate, 0.1g of ketoconazole, 0.1g of ceramide, 10g of glycerol, and 1g of glycyrrhizin into the aforementioned base, stir evenly in the same direction, and cool to room temperature.

Embodiment 3

[0022] Example 3: Take 10 g of vaseline as the base, add the medicinal ingredients 0.1 g of chlorhexidine acetate, 0.15 g of ketoconazole, 0.15 g of ceramide, 12 g of glycerol, and 1.2 g of glycyrrhizin, and stir to obtain the product.

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Abstract

The invention discloses an external preparation for treating facial seborrheic dermatitis, belongs to the technical field of medical, dental or dressing preparations, and in particular relates to an external preparation for treating facial seborrheic dermatitis. The external preparation disclosed by the invention at least comprises the following medicinal components: 0.05-0.1 part of chlorhexidine acetate, 0.05-0.15 part of ketoconazole, 0.05-0.15 part of ceramide, 8-12 parts of glycerin and 0.8-1.2 parts of glycyrrhizin. According to the external preparation disclosed by the invention, the staphylococcus epidermidis can be effectively killed by chlorhexidine acetate, the pityrosporum orbiculare is effectively inhibited by ketoconazole, the inflammatory reaction is inhibited by the glycyrrhizin, the natural moisturizing factors of cuticle are increased by the glycerin, and the epidermal barrier function is repaired by the ceramide. According to the comprehensive effects of the five medical components, the facial seborrheic dermatitis can be effectively treated.

Description

technical field [0001] The invention belongs to the technical field of preparations for medicine, dentistry or dressing, and in particular relates to an external preparation for treating facial seborrheic dermatitis. Background technique [0002] Seborrheic dermatitis (SD) is a chronic papulosquamous, superficial inflammatory skin disease that occurs at the seborrheic site. The typical rash is dark red and yellowish red spots formed by the fusion of follicular papules, covered with greasy Scales or scabs may be accompanied by varying degrees of itching. The etiology is unknown, but it was thought to be related to Pityrosporum colonization activities in the past, but the effect of antifungal therapy is not prominent, and its effectiveness is controversial. The current treatment methods for facial seborrheic dermatitis include simple anti-inflammatory drugs (such as hormone topical preparations, calcineurin inhibitors), supplemented with skin moisturizing and skin care produc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P17/08A61P31/02A61P31/04A61P31/10A61P29/00A61P17/00A61K31/496A61K31/155A61K31/164
CPCA61K31/155A61K31/164A61K31/496A61K31/704A61K2300/00
Inventor 安倩高兴华陈洪铎
Owner 大连亚维药业有限公司
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