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Medicinal use of a kind of emblica extract

A technology of Amla japonica and extract, applied in the application field of medicine, can solve the problems of less research and utilization and the like

Active Publication Date: 2018-06-19
CATCH BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is very little research and utilization of Amla emblica in the treatment of hyperuricemia and gout. Chinese patent document CN102441081A discloses a medicine for treating gout and a preparation method thereof, which is a compound composition containing fourteen medicinal materials. , emblica is one of the medicinal materials that is not a monarch drug, and the composition of the medicinal materials is only pulverized, and does not involve the extraction of any possible active ingredients or active parts

Method used

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  • Medicinal use of a kind of emblica extract
  • Medicinal use of a kind of emblica extract
  • Medicinal use of a kind of emblica extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 emblica extract

[0022] Get 2000g Amla emblica (purchased from Bozhou Medicinal Materials Market), after pulverization, soak with 16L of 70v% ethanol at room temperature for 24h, then reflux extraction at 20°C for 60min, filter the extract, add 12L of 70v% ethanol to the filter residue, Reflux for extraction for 40 minutes, filter, combine the two extracts to obtain the extract of Amla emblica, and concentrate to dryness in vacuum to obtain 700 g of crude extract of Amla emblica (coded as PEE-1), with a yield of 35%.

Embodiment 2

[0023] The preparation of embodiment 2 emblica extract

[0024] Take 2000g Amla emblica (purchased from Bozhou Medicinal Materials Market), crush it, soak it in 16L of water at room temperature for 24h, extract at 80°C for 40min, filter the extract, add 12L of water to the filter residue, and extract at 80°C for 40min , filtered, and combined the two extracts to obtain the extract of Amla emblica, which was concentrated to dryness in vacuo to obtain 900g extract of Amla emblica (coded as PEE-2), with a yield of 45%.

Embodiment 3

[0025] The preparation of embodiment 3 emblica extract

[0026] The extract of Amla emblica was prepared by the same method as in Example 1, and 200 g of the crude extract of Amla emblica was taken, dissolved in water, and chromatographically performed with D101 macroporous adsorption resin. The mass ratio of extract to resin is 1:20. Gradient elution was performed with water, 50v% ethanol, and 95v% ethanol in sequence, each gradient eluted with 4 times the column volume, and the flow rate was 3 times the column volume / hour. After the elution is completed, the water eluate, the 50v% ethanol eluate, and the 95v% ethanol eluate are concentrated to dryness to obtain a refined and purified emblica extract.

[0027] Among them, 102g of refined and purified emblica extract (coded as PEW) was obtained from the water elution site, 72g of refined and purified emblica extract (coded as PE50) was obtained from the 50v% ethanol elution site, and 95v% ethanol elution site A total of 13 g...

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Abstract

The invention discloses the medicinal use of emblica, in particular to the application of an extract of emblica in the preparation of medicine for treating hyperuricemia. Amla emblica extract has the effect of treating hyperuricemia, can effectively reduce the concentration of uric acid in the blood, and treat metabolic diseases related to hyperuricemia: acute gout, chronic gout, gouty arthritis, gout attack, uric acid Nephrolithiasis and gouty nephropathy and other diseases can play a better effect.

Description

technical field [0001] The invention relates to a new indication of Amlican emblica, in particular to the application of the extract of Amlican emblica in the preparation of medicine for treating hyperuricemia. Background technique [0002] In the field of chemical medicine, uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. Under a normal purine diet, if the blood uric acid level on an empty stomach is higher than 420 μmol / L for men and 360 μmol / L for women on two different days, it is called hyperuricemia. The prevalence of this disease is affected by many factors, related to heredity, sex, age, lifestyle, eating habits, drug treatment and economic development. According to reports on the prevalence of hyperuricemia in various places in recent years, there are currently about 120 million hyperuricemia patients in my country, accounting for about 10% of the total population. trend. With the change of peop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61P19/06A61P19/02A61P13/12
Inventor 温尧林夏增华贾远敏张新新
Owner CATCH BIO SCI & TECH
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