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Implantable flexible array electrode used for organism and preparation method of implantable flexible array electrode

A flexible array and array electrode technology, applied in the fields of biomedical engineering and electrochemical materials, can solve problems such as small safe charge capacity, and achieve the effect of reducing corrosion risk, being easy to accept, and having good adhesion.

Inactive Publication Date: 2015-04-29
WUHAN GREENTEK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The array electrodes modify the high-capacitance thin film layer on the gold-plated layer on the copper foil layer of the electrode points by electrochemical methods, so that the electrode points can enhance the ability of interface charge transmission due to high-capacitance materials, and can be used on smaller electrode points. Transmit a larger amount of charge, overcome the problem that only the gold-plated electrode points have a small safe charge capacity and cannot be used in animal nerve electrical stimulation experiments

Method used

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  • Implantable flexible array electrode used for organism and preparation method of implantable flexible array electrode
  • Implantable flexible array electrode used for organism and preparation method of implantable flexible array electrode
  • Implantable flexible array electrode used for organism and preparation method of implantable flexible array electrode

Examples

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Effect test

Embodiment 1

[0042] Example 1: It is the basic embodiment of the implantable flexible array electrode for living body of the present invention. Such as figure 1 , 2 As shown, an implantable flexible array electrode for a living body includes a flexible substrate 4, and at least two parallel strip copper foil layers 6 are deposited on the surface of the substrate 4, and one end of each copper foil layer 6 is The copper foil layer of the electrode point 1, the other end is the copper foil layer of the pad 3, and the copper foil layer in the middle is the wire 2; the copper foil layer of the electrode point 1 and the copper foil layer of the pad 3 are also plated with a gold-plated layer 7 ; The gold-plated layer 7 of the electrode point 1 is also covered with a high capacitive film layer 8; the width of the copper foil layer of the wire 2 is less than the direct warp of the copper foil layer of the circular electrode point 1; the exposed surface of the base 4 and the wire 2 There is an i...

Embodiment 2

[0044] Example 2: It is a further embodiment on the basis of the flexible array electrode in Embodiment 1. Such as figure 1 , 2 As shown, in the implantable flexible array electrode for living body, the diameter of the copper foil layer of the electrode point 1 is 0.21-5 mm, and the distance between the electrode points is 0.3-1 mm. There are 4 copper foil layers 6 and 4 electrode points 1, which are arranged in a 2×2 rectangular matrix to form an array electrode.

[0045] Another special case is that there are two copper foil layers 6 and two electrode points 1, forming an array electrode in a single row.

[0046] Both the base 4 and the insulating covering layer 5 are polymer films, the polymer films are made of polyimide, polydimethylsiloxane, or parylene materials, and the thickness is 0.01-0.03 mm. The thickness of the copper foil layer 6 is 0.01-0.2 mm. The thickness of the gold-plated layer 7 is 0.00002-0.001 mm; the thickness of the high-capacitance film layer 8...

Embodiment 3

[0047] Example 3: The difference from the flexible array electrode in Embodiment 2 is that there are 16 copper foil layers 6 and 16 electrode points 1, which are arranged in a 4×4 rectangular matrix to form an array electrode.

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Abstract

The invention relates to an implantable flexible array electrode used for an organism and a preparation method of the implantable flexible array electrode. The implantable flexible array electrode comprises a substrate, wherein the substrate is provided with copper foil layers, one end of each copper foil layer is a copper foil layer of each electrode point, the other end of each copper foil layer is a copper foil layer of each bonding pad, and a wire is arranged at the middle part of each copper foil layer; the copper foil layer of each electrode point and the copper foil layer of each bonding pad are further plated with gold plating layers; the gold plating layer of each electrode point is covered with a high-capacity film layer. The preparation method comprises steps as follows: manufacturing of copper foil layers of the electrode points, the wires and the bonding pads, hot-pressing package and gold plating and electrochemical modification of the electrode points. The implantable flexible array electrode and the preparation method have the advantages that the charge transmission performance of the array electrode is good, bidirectional functions of electrical nerve stimulation and nerve electrical recording are realized, and the array electrode can be easily accepted by a receptor, and is easy to machine and low in cost.

Description

technical field [0001] The invention relates to an implantable flexible array electrode for living organisms and a preparation method thereof. The prepared plate-shaped implantable array electrode is used in animal experiments, especially suitable for electrical stimulation experiments of the cerebral cortex of animals, and belongs to biomedical engineering and Electrochemical materials technology field. Background technique [0002] Nerve electrical stimulation and recording technology is developing rapidly in the field of biomedicine. More and more researches on the treatment and repair of neurological diseases require animal experiments to evaluate their safety and effectiveness. Cortical mapping technology is an emerging research method based on neural electrical stimulation and recording. It applies a pulse current stimulus greater than the threshold intensity to the motor cortex area of ​​the rat, and activates the motor cortex at this point to induce the movement of d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/05
Inventor 李明哲李涛段晏文周琴饶立
Owner WUHAN GREENTEK
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