Preparation method of multifunctional probe for tumor thermotherapy as magnetic resonance imaging contrast agent

A magnetic resonance contrast agent and multi-functional probe technology, which is applied in the field of nanomaterial preparation, can solve the problems of complex preparation process and tissue signal confusion, and achieve the effects of good stability, good biocompatibility and easy metabolism

Inactive Publication Date: 2015-05-20
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, probes for thermotherapy and diagnosis using Cu9S5 and Fe3O4 media have been reported (Tian Q, Hu J, Zhu Y, et al. Sub-10nm Fe3O4Cu2–x S Core–Shell Nanoparticles for Dual-Modal Imaging and Photothermal Therapy[J]

Method used

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  • Preparation method of multifunctional probe for tumor thermotherapy as magnetic resonance imaging contrast agent
  • Preparation method of multifunctional probe for tumor thermotherapy as magnetic resonance imaging contrast agent
  • Preparation method of multifunctional probe for tumor thermotherapy as magnetic resonance imaging contrast agent

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Experimental program
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Effect test

Embodiment 1

[0037] a. In deionized water with 520 parts by mass, add 20 parts of sodium diethyldithiocarbamate; The sodium carbamate aqueous solution is slowly added dropwise in the copper compound aqueous solution;

[0038] b. Magnetic stirring at room temperature for 4 hours, resulting in dark brown turbidity;

[0039] c. Add the precipitate obtained in b into 10 parts by mass of oleylamine, and continue stirring;

[0040] d. Put 30 parts by mass of oleylamine into a flask, heat at 80°C for 20 minutes, and pass through nitrogen to remove moisture and oxygen, then add the solution obtained in c into the flask, heat to 300°C, and stir magnetically 20 minutes. Then cool to room temperature, centrifuge at 10,000 rpm, wash with ethanol, and disperse with 100 parts of chloroform;

[0041] e. Mix 10 parts of the solution obtained in the above d with 100 parts by mass of a surfactant and 1000 parts of water, stir magnetically at 40°C for 48 hours, and then rotatably evaporate the resulting s...

Embodiment 2

[0047] a. In deionized water with 540 parts by mass, add 40 parts of sodium diethyldithiocarbamate; in deionized water with 540 parts by mass, add 60 parts of copper compound, diethyldithiocarbamate The sodium carbamate aqueous solution is slowly added dropwise in the copper compound aqueous solution;

[0048] b. Magnetic stirring at room temperature for 5 hours, resulting in dark brown turbidity;

[0049] c. Add the precipitate obtained in b into 30 parts by mass of oleylamine, and continue stirring;

[0050] d. Put 100 parts by mass of oleylamine into a flask, heat at 85°C for 30 minutes, and pass through nitrogen to remove moisture and oxygen, then add the solution obtained in c into the flask, heat to 300°C, and stir magnetically for 20 minutes. ~40 minutes. Then cool to room temperature, centrifuge at 10,000 rpm, wash with ethanol, and disperse with 110 parts of chloroform;

[0051] e. Mix 10 parts of the solution obtained in the above d with 110 parts by mass of surfa...

Embodiment 3

[0057] a. In deionized water with 550 parts by mass, add 50 parts of sodium diethyldithiocarbamate; The sodium carbamate aqueous solution is slowly added dropwise in the copper compound aqueous solution;

[0058] b. Magnetic stirring at room temperature for 6 hours, resulting in dark brown turbidity;

[0059] c. Add the precipitate obtained in b into 50 parts by mass of oleylamine, and continue stirring;

[0060] d. Put 100 parts by mass of oleylamine into a flask, heat at 80°C for 40 minutes, and pass through nitrogen to remove moisture and oxygen, then add the solution obtained in c into the flask, heat to 300°C, and magnetically stir 40 minutes. Then cool to room temperature, centrifuge at 12000 rpm, wash with ethanol, and disperse with 150 parts of chloroform;

[0061] e. Mix 10 parts of the solution obtained in the above d with 120 parts by mass of surfactant and 1500 parts of water, stir magnetically at 60°C for 72 hours, and then rotate the obtained solution at 50°C ...

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Abstract

The invention provides a preparation method of a multifunctional probe for tumor thermotherapy as a magnetic resonance imaging contrast agent. The preparation method of the multifunctional probe comprises the following steps: dropwise adding the solution of sodium diethyldithiocarbamate of water into the solution of a copper compound in water, stirring to obtain a blackish brown precipitate which is diethyl dithio amino copper, and drying the precipitate in vacuum; adding a diethyl dithio amino copper containing solution of oleylamine into hot oleylamine, introducing nitrogen into the mixture, heating the mixture, stirring, cooling to room temperature, washing, centrifuging, dispersing into a stabilizer, and evaporating in a rotating way; adding a surfactant, stirring, and filtering to obtain a transparent blackish green solution; adding ethanol into the blackish green solution, oscillating ultrasonically, stirring, adding an alkali, a silicon source and a magnetic compound, and stirring to form nanoparticles in core-shell structures. The probe heats tissues by adopting the heat effect generated in the tissues of a human body by a variety of physical energy such as microwaves, radio frequency and ultrasonic waves to accelerate the death of tumour cells, and the probe can be used as the magnetic resonance imaging contrast agent.

Description

technical field [0001] The invention relates to the field of preparation of nanometer materials, in particular to a method for preparing a multifunctional probe for tumor hyperthermia and magnetic resonance contrast agent. Background technique [0002] Tumor hyperthermia is a tumor treatment method that has developed rapidly in recent years. It refers to heating the tumor area or the whole body to the effective therapeutic temperature range through the thermal effect of various heat sources, and maintaining it for a certain period of time to kill tumor cells. treatment method. As a physical therapy method, hyperthermia has the biggest advantage of being non-invasive or minimally invasive compared with chemotherapy and radiotherapy, which can effectively relieve pain and improve the quality of life of patients. At present, the application prospect of hyperthermia in tumor treatment has been confirmed. It can stagnate blood vessels in tumor tissue with slow blood flow through...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/08A61P35/00
Inventor 何丹农刘恬姚燕杰朱君金彩虹
Owner SHANGHAI JIAO TONG UNIV
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