Preparation method of beta-amino acetal

Abstract

The invention discloses a preparation method of beta-amino acetal, and belongs to the organic chemical synthesis technical field. The method comprises that a metal is taken as a catalyst, in an organic solvent, vinyl ether undergoes a reaction with alcohol, amine and aldehyde or with alcohol and amine acetal at the temperature of 25-140 DEG C and a one-pot reaction is carried out at one step for efficiently preparing beta-amino acetal. The reaction raw materials and the catalyst are cheap and easy to get, and the synthetic process is simple; the reaction conditions are mild, the yield is high, and industrialization is easy to implement; the reaction raw materials and the catalyst are clean and non-toxic, and have little pollution to the environment; and the product can be further transformed to synthesize various non-natural beta-amino acids and beta-amino alcohols.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a preparation method of β-amino acetal. Background technique [0002] β -Aminoaldehyde is an important pharmacophore and an important intermediate in the synthesis of peptides, pesticides, medicines and natural products. β -Aminoacetal can be considered as the equivalent of aminoaldehyde, which can be synthesized by deprotection by hydrolysis β- Amino aldehydes. β -The preparation of aminoaldehyde can also be corresponding β - Reduction of amino acids to β -Aminoalcohols, which are then synthesized by selective oxidation. Synthesized by amino acid reduction and oxidation method β - Amino aldehyde is not only complicated in process, but also needs to use a large amount of reducing agent and oxidizing agent, the atom economy is low, and the cost is high, and because common natural amino acids are generally α - amino acids, β- The source of ami...

AI Technical Summary

Problems solved by technology

[0004] Existing methods are not easy to produce on a large scale due to various shortcomings, for example: method 1, the preparation of nitroacetal needs to use formyl acetal as a raw material, and requires a large amount of alkali at the same time, during the addition reaction process A large amount of organometallic reagents are required, the atom economy is poor, the operation is complicated, and the steps are long; method two, β- Bromopropyl acetal is not easy to prepare, and needs to use a large amount of alkali simultaneously, and reaction selectivity is poor, and yield is low; Method 3, must use aromatic aldehyde to form imine with amine first, and substrate adaptability is poor, needs to carry out at low temperature, The operation is complicated, and the aminoaldehyde obtained at the same time has poor stability and is not easy to store