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Pain relieving cataplasm for relaxing tendon and activation collaterals and preparation method of pain relieving cataplasm

A technology for relaxing tendons and activating collaterals and baboon ointment, applied in the field of medicine, can solve the problems of easy adhesion of body hair, difficulty in peeling and sticking, high skin irritation, etc., achieving less irritation and allergy, inhibiting the growth of mold, and good skin followability. Effect

Active Publication Date: 2015-05-27
ANHUI ANKE YULIANGQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Shujinhuoluo Zhitong ointment is a rubber ointment. The disadvantages of this dosage form are poor air permeability, high skin irritation, and prone to allergic reactions. When used, the adhesiveness is too large, and it is easy to stick to body hair, which makes it difficult to peel off. Not only that , Shujinhuoluozhipain Ointment uses gasoline to dissolve natural rubber in production, so there are defects such as hidden dangers in production safety and pollution of the environment
[0003] The applicant previously applied for an invention patent (application number 201310653159.9) titled "Huoxue Zhitong Pabu Plaster and Its Preparation Method". A blood-activating and pain-relieving catarrh plaster and its preparation method. Based on the technical scheme disclosed in this patent, the applicant tried to combine the sixteen traditional Chinese medicines used to prepare the Shujin Huoxuezhipain plaster with the matrix components used in the preparation of the Huoxuezhipao plaster. (i.e. carbomer, povidone K30, gelatin, sodium polyacrylate, disodium edetate, glycerin, ethylparaben, ethanol, and water) were combined to prepare Shujinhuoluozhipao paste, but the test It was found that the viscoelasticity of the medicinal extract prepared by the above technical scheme was poor after being mixed with the matrix, it was difficult to coat, and it could not be shaped. That is to say, the matrix components used in the preparation of different products of the same dosage form are by no means universal of

Method used

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  • Pain relieving cataplasm for relaxing tendon and activation collaterals and preparation method of pain relieving cataplasm
  • Pain relieving cataplasm for relaxing tendon and activation collaterals and preparation method of pain relieving cataplasm
  • Pain relieving cataplasm for relaxing tendon and activation collaterals and preparation method of pain relieving cataplasm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Preparation of Shujinhuoxuezhitong Babu Ointment

[0044] 1) Weigh the following raw materials in parts by weight: Rhizoma Drynariae 7, Dipsacus 7, Wood Beetle 4, Notopterygium 7, Aracea 7, Frankincense 1, Myrrh 1, Angelica 7, Peach Kernel 5, Wujiapi 7, Dandelion 7. Safflower 7, borneol 0.5, camphor 1, methyl salicylate 1, eucalyptus oil 0.5, carbomer 5, partially neutralized sodium polyacrylate 10, edetate disodium 0.1, povidone K30 is 5. Gelatin 10, Glycerin 60, Ethylparaben 1, Aluminum Glycol 0.1, Citric Acid 0.05, Ethanol 1, Water 150;

[0045] 2) Add 8 times the weight of water to the ground beetle and the peach kernel for decoction respectively, combine the decoction liquid of the wood beetle and the peach kernel, filter, and concentrate the filtrate into a water-extracted thick paste with a relative density of 1.25g / ml. Drynariae, Dipsacus, Notopterygium, Angelica, Araceae, Safflower, Dandelion, Frankincense, Myrrh and Wujiapi are mixed and pulverized...

Embodiment 2

[0049] Example 2: Preparation of Shujinhuoxuezhitong Babu Ointment

[0050]1) Weigh the following raw materials in parts by weight: Rhizoma Drynaria 11, Dipsacus 11, Wood Beetle 8, Notopterygium 11, Aracea 11, Frankincense 5, Myrrh 5, Angelica 11, Peach Kernel 5, Wujiapi 11, Dandelion 11. Safflower 11, Borneol 1.5, Camphor 3, Methyl Salicylate 2, Eucalyptus Oil 1.5, Carbomer 60, Partially Neutralized Sodium Polyacrylate 90, Disodium EDTA 2, Povidone K30 is 80. Gelatin 120, Glycerin 180, Ethylparaben 5, Aluminum Glycol 2, Citric Acid 1, Ethanol 8, Water 300;

[0051] 2) Add 15 times the weight of water to the ground beetle and the peach kernel for decoction respectively, combine the decoction liquid of the wood beetle and the peach kernel, filter, and concentrate the filtrate into a thick paste with a relative density of 1.26g / ml. Rhizoma Drynariae, Dipsacus, Notopterygium, Angelica, Aracea, Safflower, Dandelion, Frankincense, Myrrh and Wujiapi are mixed and pulverized to obta...

Embodiment 3

[0055] Example 3: Preparation of Shujinhuoxuezhitong Babu Ointment

[0056] 1) Weigh the following raw materials in parts by weight: Rhizoma Drynaria 9, Dipsacus 9, Wood Beetle 6, Notopterygium 9, Araceae 9, Frankincense 3, Myrrh 3, Angelica 9, Peach Kernel 4.5, Wujiapi 9, Dandelion 9. Safflower 9, Borneol 1, Camphor 2, Methyl Salicylate 1.5, Eucalyptus Oil 1, Carbomer 10, Partially Neutralized Sodium Polyacrylate 20, Disodium EDTA 0.1, Povidone K30 is 20. Gelatin 15, Glycerin 100, Ethylparaben 3, Aluminum Glycol 1, Citric Acid 1, Ethanol 5, Water 200;

[0057] 2) Add 10 times the weight of water to the ground beetle and the peach kernel for decoction respectively, combine the decoction liquid of the wood beetle and the peach kernel, filter, and concentrate the filtrate into a thick paste with a relative density of 1.26g / ml. Drynariae, Dipsacus, Notopterygium, Angelica, Aracea, Safflower, Dandelion, Frankincense, Myrrh and Wujiapi are mixed and pulverized to obtain a mixed co...

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Abstract

The invention discloses a pain relieving cataplasma for relaxing tendon and activation collaterals. The pain relieving cataplasma comprises 1-5 weight parts of active pharmaceutical ingredient and 30-300 weight parts of matrix, wherein the matrix is prepared from the following raw materials in parts by weight: 5-60 parts of Carbopol, 10-90 parts of partial neutrolization sodium polyacrylate, 0.1-2 parts of ethylenediamine tetraacetic acid, 5-80 parts of povidone K30, 10-120 parts of gelatin, 60-180 parts of glycerinum, 1-5 parts of ethylparaben, 0.1-2 parts of dihydroxyaluminium aminoacetate, 0.05-1 part of citric acid, 1-8 parts of ethyl alcohol and 150-300 parts of water. The invention further discloses a preparation method for the pain relieving cataplasmata, the pain relieving cataplasmat for relaxing tendon and activation collaterals prepared by the method is simple in process and safe in production, has no pollution to the environment, the efficacy of the pain relieving cataplasma is obvious, and the pain relieving cataplasmat generates little irritation and allergy to the skin.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for relaxing tendons and activating collaterals and a preparation method thereof. Background technique [0002] Shujin Huoluo Zhitong Plaster (formerly known as Jieguling Tie Plaster) is a Chinese patent medicine that has been on the market for many years. Its prescription includes sixteen traditional Chinese medicines such as Drynaria Drynariae, Dipsacus, Notopterygium, and Angelica. , the effect of reducing swelling and relieving pain, it is mainly used in the treatment of various closed new fractures and soft tissue injuries such as bruises, sprains and contusions in clinical practice, with remarkable curative effect. However, Shujinhuoluo Zhitong ointment is a rubber ointment. The disadvantages of this dosage form are poor air permeability, high skin irritation, and prone to allergic reactions. When used, the adhesiveness is too large, and it is easy to ...

Claims

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Application Information

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IPC IPC(8): A61K36/8884A61K47/32A61K47/42A61K47/10A61K47/14A61K9/70A61P29/00A61K31/045A61K31/125A61K31/618A61K35/64
Inventor 刘道芳刘海兵谢红星田湘玲徐莉莉廖华宁
Owner ANHUI ANKE YULIANGQING PHARMA
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