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Application of swine enzootic hyopneumoniae vaccine strain

A technology of mycoplasma pneumoniae and mycoplasma hyopneumoniae, which is applied in the direction of bacterial antigen components and antibacterial drugs, can solve the problems of difficult popularization and expensive vaccines, and achieve the effect of simple vaccine production method, safe and effective vaccine, and good immunogenicity

Inactive Publication Date: 2015-05-27
TECON BIOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the domestic self-developed Mycoplasma pneumonia vaccine is only attenuated vaccine, which is not easy to popularize due to the need for chest cavity inoculation. However, many foreign veterinary drug companies have developed and produced inactivated vaccines for Mycoplasma pneumonia in the domestic market. Sales, inactivated vaccines can be vaccinated by intramuscular injection, easy to handle
Since there is no self-developed inactivated vaccine for mycoplasma pneumonia in China, the market relies on imports, and the price of imported vaccines is relatively expensive

Method used

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  • Application of swine enzootic hyopneumoniae vaccine strain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: the preparation of swine mycoplasma pneumonia inactivated vaccine (CJ strain):

[0021] 1 strain:

[0022] 1.1 The bacterial classification used to manufacture this product is Mycoplasma hyopneumoniae CJ strain (the said Mycoplasma hyopneumoniae vaccine strain, its classification is called Mycoplasma hyopneumoniae (Mycoplasma hyopneumoniae), and the bacterial strain number is CJ, has been deposited in China Microorganism Strain Preservation Management Committee General Microbiology Center, the preservation number is CGMCC NO: 9909, and the preservation date is November 06, 2014). The strain used for inspection is Mycoplasma suis pneumonia lung tissue virus, which was isolated, identified, and tested by Xinjiang Tiankang Animal Husbandry Biotechnology Co., Ltd. custody and supply;

[0023] 1.2 Bacteria for production:

[0024] 1.2.1 Morphology and biochemical characteristics: smeared with liquid culture, stained by Gimu Sax, under high magnification, typi...

Embodiment 2

[0053] Embodiment 2: Observation of immune effect of swine mycoplasma pneumonia inactivated vaccine (CJ strain)

[0054] Vaccine: Mycoplasma pneumonia inactivated vaccine (CJ strain) (aluminum hydroxide adjuvant), Mycoplasma pneumonia inactivated vaccine (CJ strain) (ISA 206), Mycoplasma pneumonia inactivated vaccine (CJ strain) (ISA 11R) , Mycoplasma pneumonia inactivated vaccine (CJ strain) (ISA 760), Mycoplasma pneumonia inactivated vaccine (CJ strain) (ISA 563), Mycoplasma pneumonia inactivation vaccine (CJ strain) (Gel 01), imported Mycoplasma suis Pneumonia inactivated vaccine;

[0055] Bacteria used for inspection: Mycoplasma hyopneumoniae lung tissue virus, isolated, identified, kept and supplied by Xinjiang Tiankang Animal Husbandry Biotechnology Co., Ltd.;

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Abstract

The invention relates to a novel application of a swine enzootic hyopneumoniae vaccine strain, in particular to an application of the swine enzootic hyopneumoniae vaccine strain in preparing a veterinary medicine for treating swine enzootic hyopneumoniae. The swine enzootic hyopneumoniae vaccine strain is named and classified as Mycoplasma hyopneumoniae and CJ, and is preserved in China General Microbiological Culture Collection Center with the preservation Number of CGMCC NO:9909 on November 6, 2014. The strain for an inactivated vaccine is separated and obtained from a commercial swine in China, and has high growth titer and good immunogenicigy, and the inactivated vaccine has a simple preparation process, is safe and effective, and can effectively prevent the swine enzootic hyopneumoniae.

Description

technical field [0001] The invention belongs to the field of veterinary biological products and relates to the application of a new vaccine strain of swine mycoplasma pneumoniae. Background technique [0002] Mycoplasma pneumonia, also known as swine endemic pneumonia (Swine enzootic hyopneumoniae), commonly known as swine panting disease in my country, is a chronic, contact, respiratory infectious disease caused by Mycoplasma hyopneumoniae. The main clinical symptoms are cough and wheezing, often secondary infection by other bacteria (such as Pasteurella multocida, Haemophilus parasuis, Actinobacillus pleuropneumoniae, etc.). The disease is widely distributed all over the world, and occurs in pig farms in many areas of our country. Due to the existence and wide distribution of pigs with bacteria-carrying disease, it usually causes a significant decline in the production performance of the pig herd, a decrease in the daily gain of the infected pig herd, a reduction in feed ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/02A61P31/04
Inventor 王钢候凤李新苹贺笋李延涛
Owner TECON BIOLOGY CO LTD
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