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Visual thrombolytic agent applied to reverse thrombolysis method and application method of visual thrombolytic agent

A technology of thrombolytic agent and thrombolytic method, applied in the field of visualized thrombolytic agent, can solve the problems of inconvenient rescue and treatment of patients, achieve the effect of facilitating rescue and treatment, and improving the use efficiency

Inactive Publication Date: 2015-06-17
田进文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a visualized thrombolytic agent for reverse thrombolytic method to solve the technical problem in the prior art that it is inconvenient for doctors to rescue and treat patients

Method used

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  • Visual thrombolytic agent applied to reverse thrombolysis method and application method of visual thrombolytic agent
  • Visual thrombolytic agent applied to reverse thrombolysis method and application method of visual thrombolytic agent
  • Visual thrombolytic agent applied to reverse thrombolysis method and application method of visual thrombolytic agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 5 mg of the thrombolytic agent prourokinase, and dissolve the thrombolytic agent in 10000 mg (10 ml) of 0.9% sodium chloride solution (weight ratio 1:2000). Then take 5ml of contrast agent iopromide injection (Uvesin 370), add iopromide to the mixed solution of prourokinase and 0.9% sodium chloride (volume ratio 1:2), and visualize thrombolysis Dose 15ml. The doctor passes a guide wire through the blockage of the criminal vessel, and the microcatheter is supported by the guide wire through the blockage to its distal end. Use a syringe to extract the above-mentioned visualized thrombolytic agent, and inject the visualized thrombolytic agent into the distal end of the blocked segment. At this time, X-ray fluoroscopy can be used to see the thrombolysis in the criminal blood vessel. The doctor injected 1ml of visualized thrombolytic agent into the criminal blood vessel every 30 seconds, and observed the thrombolysis with X-ray perspective. At the beginning, the visu...

Embodiment 2

[0036] Take 5 mg of the thrombolytic agent prourokinase, add the thrombolytic agent to 30000 mg (30 ml) of 0.9% sodium chloride solution (1:6000 weight ratio), and dissolve the thrombolytic agent in 0.9% sodium chloride. Then take 5 ml of iopromide injection (Uvesin 370), add iopromide to the mixed solution of urokinase and 0.9% sodium chloride (1:6 volume ratio), and obtain 45 ml of visualized thrombolytic agent. The doctor passes a guide wire through the blockage of the criminal vessel, and the microcatheter is supported by the guide wire through the blockage to its distal end. Use a syringe to extract the above-mentioned visualized thrombolytic agent, and inject the visualized thrombolytic agent into the distal end of the blocked segment. At this time, X-ray fluoroscopy can be used to see the thrombolysis in the criminal blood vessel. The doctor injected 1ml of visualized thrombolytic agent into the criminal blood vessel every 30 seconds, and observed the thrombolysis with...

Embodiment 3

[0038] Take 5 mg of the thrombolytic agent prourokinase, add the thrombolytic agent to 20000 mg (20 ml) of 0.9% sodium chloride, and dissolve the thrombolytic agent in 0.9% sodium chloride (weight ratio 1:4000). Then take 5ml of iopromide injection (Ulvitex 370), add iopromide to the mixed solution of prourokinase and 0.9% sodium chloride (volume ratio 1:4), and obtain 25ml of visualized thrombolytic agent . The doctor passes a guide wire through the blockage of the criminal vessel, and the microcatheter is supported by the guide wire through the blockage to its distal end. Use a syringe to extract the above-mentioned visualized thrombolytic agent, and inject the visualized thrombolytic agent into the distal end of the blocked segment. At this time, X-ray fluoroscopy can be used to see the thrombolysis in the criminal blood vessel. The doctor injected 1ml of visualized thrombolytic agent into the criminal blood vessel every 30 seconds, and observed the thrombolysis with X-ra...

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Abstract

The invention relates to the technical field of thrombolysis and particularly relates to a visual thrombolytic agent applied to a reverse thrombolysis method and an application method of the visual thrombolytic agent. The visual thrombolytic agent comprises a thrombolytic agent, a contrast agent and a solvent which is applied to the human body and matched with plasma osmotic pressure. A double-chamber micro guide pipe penetrates through a lesion position in the blood vessel of a crime and reaches a far end of the blood vessel under the guidance of a guide wire; an injector is used for injecting the visual thrombolytic agent into the double-chamber micro guide pipe, so that the visual thrombolytic agent can be injected to the far end of the lesion position; at the far end of the lesion position, the blood flows quite slowly and even stops, so that the visual thrombolytic agent can stay at the far end of the lesion position; a thrombolysis treatment is performed after the visual thrombolytic agent comes into contact with thrombus. Since the visual thrombolytic agent contains the contrast agent, a doctor can observe the whole thrombolysis process under imaging of X ray so as to judge the thrombolysis progress and regulate the use amount of the visual thrombolytic agent and the feeding speed in real time, and thus the application efficiency of the visual thrombolytic agent is improved and the doctor can rescue and treat patients conveniently.

Description

technical field [0001] The invention relates to the technical field of thrombolysis, in particular to a visualized thrombolytic agent for reverse thrombolytic method and its application method. Background technique [0002] Emergency PCI refers to the coronary artery revascularization performed within 12 hours after the patient has acute myocardial infarction. The patient first undergoes coronary angiography in the cardiac catheterization laboratory to find out the coronary "culprit" blood vessel and its lesion site. Percutaneous transluminal coronary angioplasty and implantation of stents at the lesion site can recanalize the occluded blood vessels, and early reperfusion and functional recovery of the infarction-related myocardium. It can be said that emergency PCI has built a green channel in the shortest time to save the dying life of acute myocardial infarction, and improves the success rate of rescue of critically ill patients. [0003] Acute myocardial infarction (AMI...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K45/00A61K49/04A61K38/49A61P7/02A61K38/54
Inventor 田进文
Owner 田进文