Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of gastric floating hollow sustained-release tablet

A sustained-release tablet and gastric floating technology, which is applied in the direction of making medicines into special physical or ingestible devices, pill delivery, active ingredients of heterocyclic compounds, etc., can solve the problem of complex manufacturing process, easy damage, and easy breakage and other problems, to achieve the effect of simple manufacturing process, prolonging the integrity time, and maintaining continuous floating

Active Publication Date: 2018-01-16
HUAQIAO UNIVERSITY
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dome The structure is a typical structure of hollow preparations currently being studied abroad, however Dome The hollow tablet of structure needs to press the tablet of two kinds of complementary structures, and manufacturing process is complicated, and at the same time, Dome The hollow tablet of the structure mainly uses physical fit so that the two can be combined. The tablet structure of this combination is not firm, easy to break, and is more likely to be damaged during the dissolution process, which makes the tablet’s stability in the gastric juice The floating time can only reach 5-6 hours

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of gastric floating hollow sustained-release tablet
  • A kind of preparation method of gastric floating hollow sustained-release tablet
  • A kind of preparation method of gastric floating hollow sustained-release tablet

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] a. Preparation of plain tablets: Weigh the main drug and various pharmaceutical excipients in the prescribed amount, mix them evenly, pass through a No. 5 sieve (180 μm ± 7.6 μm), and use a tableting mold to compress out a concave surface in the middle and a peripheral edge. Planar tablets, such as Figure 1a shown, spare;

[0038] b, the preparation of coating solution: take the tablet coating material of prescribed quantity, plasticizer and anti-tack agent and dissolve in solvent, fully stir, filter with No. 3 sieve (355 μm ± 13 μm), obtain coating solution for subsequent use If the prescription of the coating solution includes an antifoaming agent, then add the antifoaming agent after the above-mentioned stirring, then stir for 30min, and finally filter with a No. 3 sieve (355 μm ± 13 μm) to obtain the coating solution for subsequent use;

[0039] c. Preparation of tablet unit: Use the above-mentioned coating solution to evenly spray the concave surface and its perip...

Embodiment 1

[0058] Example 1: Diltiazem hydrochloride gastric floating hollow sustained-release tablet

[0059] (1) Prescription composition

[0060] A, plain tablet prescription:

[0061] Component name Dosage (1000 tablets)

[0062] Main medicine:

[0063] Diltiazem Hydrochloride 100g

[0064] medical supplements:

[0065]

[0066] B, coating liquid prescription:

[0067]

[0068]

[0069] (2) Determination of cumulative release

[0070] According to ultraviolet spectrophotometry, the absorbance was measured at the wavelength of 236nm, and the cumulative release was calculated. The results are as follows figure 2 shown.

Embodiment 2

[0071] Example 2: Norfloxacin gastric floating hollow sustained-release tablet

[0072] (1) Prescription composition

[0073] A, plain tablet prescription:

[0074] Component name Dosage (1000 tablets)

[0075] main medicine

[0076] Norfloxacin 200g

[0077] medical supplements:

[0078]

[0079] B, coating liquid prescription:

[0080]

[0081] (2) Determination of cumulative release

[0082] According to ultraviolet spectrophotometry, the absorbance was measured at the wavelength of 278nm, and the cumulative release was calculated. The results are as follows image 3 shown.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a novel stomach-floating hollow sustained-release tablet, which comprises: (1) preparation of a plain tablet with a concave surface in the middle; (2) bonding of the plain tablet and a bonding process. The present invention also provides a gastric floating sustained-release tablet prepared by the above method, the tablet can maintain a floating state in the gastric juice for more than 24 hours, and during the process, the drug can be released slowly and continuously until the release is complete. The novel gastric floating hollow sustained-release tablet provided by the invention can better maintain the blood drug concentration in a steady state, improve bioavailability and reduce side effects.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a gastric floating hollow sustained-release tablet and a preparation method thereof. Background technique [0002] Sustained-release preparations refer to the release of drugs slowly and non-constantly in a prescribed release medium as required. Compared with the corresponding ordinary preparations, the dosing frequency is reduced by half or less than that of ordinary preparations, and can A formulation that significantly increases patient compliance. Sustained-release preparations are mainly to prolong the dissolution, release, and absorption of drugs in the body through appropriate methods, so as to reduce the fluctuation of plasma drug concentration, reduce the number of administrations, improve the efficacy of drugs, and reduce adverse reactions. [0003] Gastric floating sustained-release preparations are a special type of preparation mainly composed o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/24A61J3/00A61K47/38A61K47/36A61K31/403A61K31/522A61K31/496A61K31/554
Inventor 王立强应侠
Owner HUAQIAO UNIVERSITY