Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of preparation method of Ganfule soft capsule

A technology of soft capsules and Ganfule, applied in capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems that still need further research, unsatisfactory curative effect, low efficiency of liver cancer, etc., and achieve market development Good prospects, good patient compliance, and scientific and reasonable data ratio

Active Publication Date: 2020-01-10
KAMP PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 90% of patients lost the chance of surgery due to large tumors or liver cirrhosis; normal liver cells are sensitive to radiation, while liver cancer cells are less sensitive, requiring > 4000cGy to obtain certain local control; local ablation therapy can achieve local Tumor control, symptom relief, etc. can be used as a treatment option for patients who cannot accept surgical resection, but it is only effective for liver cancer with tumors smaller than 5cm; the partial remission rate of chemotherapy drugs for liver cancer is below 20%, and the curative effect is not ideal; Catheter chemoembolization (TACE) or TACE plus portal vein embolization (PVE) has improved the effective rate and improved the survival time, but further studies are needed in terms of whether the arterial embolization is complete, the best drug combination, and the best embolization model. Research; the effective rate of biological targeted therapy for primary liver cancer is less than 10%

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Ingredients and proportions of raw medicinal materials: Codonopsis 2-7%, Turtle Shell (made with vinegar) 0.5-5%, Chonglou 2-7%, Atractylodes Rhizome (stir-fried), 2-7% of Astragalus, 2-7% of Chenpi , ground turtle 0.5-5%, rhubarb 0.1-2%, peach kernel 1-6%, Scutellaria barbata 2-7%, Patrinia 2-7%, Poria cocos 2-7%, coix seed 2-7%, Gold 2-7%, Sappan 2-7%, Oyster 2-7%, Capillary 2-7%, Chuan Akebia 2-7%, Cyperus 2-7%, Agarwood 0.5-3%, Bupleurum 1 -5%.

[0051] (2) Extraction process of volatile oil: extract volatile oil from agarwood, Atractylodes macrocephala, tangerine peel, Patrinia, turmeric, capillary, Cyperus cyperi and Bupleurum, add water to 12 times, extract for 5 hours, collect volatile oil, and water extract , The dregs of the medicine are for use.

[0052] (3) Water extraction process: decoct (2) traditional Chinese medicine dregs and Codonopsis pilosula and other medicinal materials, add water 10 times, extract time 2 hours, and extract twice.

[0053] ...

Embodiment 2

[0063] (1) Ingredients and proportions of raw medicinal materials: Codonopsis 2-7%, Turtle Shell (made with vinegar) 0.5-5%, Chonglou 2-7%, Atractylodes Rhizome (stir-fried), 2-7% of Astragalus, 2-7% of Chenpi , ground turtle 0.5-5%, rhubarb 0.1-2%, peach kernel 1-6%, Scutellaria barbata 2-7%, Patrinia 2-7%, Poria cocos 2-7%, coix seed 2-7%, Gold 2-7%, Sappan 2-7%, Oyster 2-7%, Capillary 2-7%, Chuan Akebia 2-7%, Cyperus 2-7%, Agarwood 0.5-3%, Bupleurum 1 -5%.

[0064] (2) Extraction process of volatile oil: extract volatile oil from agarwood, Atractylodes macrocephala, tangerine peel, Patrinia, turmeric, capillary, Cyperus cyperi and Bupleurum, add water 8 times, extract for 4 hours, collect volatile oil, water extract , The dregs of the medicine are for use.

[0065] (3) Water extraction process: decoct (2) traditional Chinese medicine dregs and Codonopsis pilosula and other medicinal materials, add water 8 times, extraction time 1.5h, extraction times 2 times.

[0066] (4...

Embodiment 3

[0077] (1) Ingredients and proportions of raw medicinal materials: Codonopsis 2-7%, Turtle Shell (made with vinegar) 0.5-5%, Chonglou 2-7%, Atractylodes Rhizome (stir-fried), 2-7% of Astragalus, 2-7% of Chenpi , ground turtle 0.5-5%, rhubarb 0.1-2%, peach kernel 1-6%, Scutellaria barbata 2-7%, Patrinia 2-7%, Poria cocos 2-7%, coix seed 2-7%, Gold 2-7%, Sappan 2-7%, Oyster 2-7%, Capillary 2-7%, Chuan Akebia 2-7%, Cyperus 2-7%, Agarwood 0.5-3%, Bupleurum 1 -5%.

[0078] (2) Extraction process of volatile oil: extract volatile oil from agarwood, Atractylodes macrocephala, tangerine peel, Patrinia, turmeric, capillary, Cyperus cyperi and Bupleuri, add water 10 times, extract for 5 hours, collect volatile oil, and water extract , The dregs of the medicine are for use.

[0079] (3) Water extraction process: decoct (2) traditional Chinese medicine dregs and Codonopsis pilosula and other medicinal materials, add water 12 times, extract time 2.5 hours, and extract once.

[0080] (4)...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Ganfule soft capsule and a preparation method thereof. The preparation method of the Ganfule soft capsule comprises volatile oil extraction, water-based extraction, refining, volatile oil microcapsule preparation and soft capsule preparation. The Ganfule soft capsule is obtained by repeated tests and improvement, has a scientific and reasonable formula, can be disintegrated fast, has good targeting effects and definite therapeutic effects, gives a great breakthrough in the field of primary liver cancer treatment and has a medical use and market development prospect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a Ganfule soft capsule and a preparation method thereof. Background technique [0002] Liver cancer is a malignant tumor that originates from liver cells and intrahepatic biliary striata, also known as primary liver cancer. There are no obvious symptoms and signs at the beginning of the disease. With the development of the disease, progressive enlargement of the liver and gallbladder, pain, anorexia, fatigue, obvious weight loss, obvious fullness of the abdomen, jaundice, low fever and high fever appear. The etiology and pathogenesis of liver cancer: ①Invasion by evil poison, external evil poison invades the human body or muscle surface by taking advantage of the deficiency, or hides in the body, causing dysfunction of viscera and internal organs, qi reversed and disordered, leading to qi accumulation and blood coagulation over time. ② Emotional disorder, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/9066A61P35/00A61P1/16A61J3/07A61K35/586A61K35/64A61K35/618
Inventor 曾培安曾灿丽吴健民张静贺莲刘娟
Owner KAMP PHARMA