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Medicine-carrying nano antibacterial super-smooth coating for marine organisms

A drug-loaded nano and marine biological technology, applied in the direction of coatings, catheters, etc., can solve the problems of increasing patient pain, high toxicity and side effects, etc., achieve convenient and quick implantation, and improve the effect of antibacterial effect

Active Publication Date: 2015-07-01
青岛高新区尚达医药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the existing antibacterial catheters, nano-silver catheters have the most rapid antibacterial effect and other advantages, but they have high toxicity and side effects. Since there is no reasonable test method to explain the metabolic pathway of nano-silver in the body, the national medical policy has strict supervision on nano-silver medical device catheters.
In addition, most antibacterial catheters are difficult to achieve a sustained and stable antibacterial effect, which increases the pain caused by repeated catheter replacements for patients

Method used

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  • Medicine-carrying nano antibacterial super-smooth coating for marine organisms
  • Medicine-carrying nano antibacterial super-smooth coating for marine organisms
  • Medicine-carrying nano antibacterial super-smooth coating for marine organisms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of drug-loaded nano-antibacterial sustained-release coating: chitosan and chlorhexidine were prepared into gel solution by ion cross-linking;

[0032] (2) Place the silicone tube body of the urinary catheter in an ethanol solution with a volume concentration of 75%, and clean it ultrasonically for 10-15 minutes at 30-50°C;

[0033] (3): After washing the silicone tube body of the catheter cleaned in step 2 with purified water, immerse it in a reactive silane solution for silica gel activation;

[0034] (4): Immerse the silicone tube body of the catheter activated by the silica gel in step 3 into the glue prepared in step 1, add a certain amount of DCC, and maintain the chemical reaction for 15-20 minutes. The amount of DCC is 1-1% of the weight of the glue in step 1. 2%;

[0035] (5): After the reaction is completed, take out the silicone tube body of the catheter, wash it with purified water, and then immerse the silicone tube body in the polyethylene ...

Embodiment 2

[0042] (1) Preparation of drug-loaded nano-antibacterial sustained-release coating: oligochitosan and triclosan were prepared into a gel by emulsification and cross-linking;

[0043](2) Place the silicone body of the diversion tube in an ethanol solution with a volume concentration of 75%, and clean it ultrasonically for 10-15 minutes at 30-50°C;

[0044] (3): After washing the silicone tube body of the catheter cleaned in step 2 with purified water, immerse it in a reactive silane solution for silica gel activation;

[0045] (4): Immerse the silicone tube body of the catheter activated by the silica gel in step 3 into the gel prepared in step 1, add a certain amount of EDCI or EDC, and maintain the chemical reaction for 15-20 minutes. The amount of EDCI or EDC is the gel in step 1 1-2% of weight;

[0046] (5): After the reaction is completed, take out the silicone tube body of the catheter, wash it with purified water, and then immerse the silicone tube body in the polyvinyl...

Embodiment 3

[0053] (1) Preparation of drug-loaded nano-antibacterial slow-release coating: prepare chitin and iodide into a gel solution by ion cross-linking;

[0054] (2) Place the silicone tube body of the suction connection tube in an ethanol solution with a volume concentration of 75%, and clean it ultrasonically for 10-15 minutes at 30-50°C;

[0055] (3): After washing the silicone tube body of the catheter cleaned in step 2 with purified water, immerse it in a reactive silane solution for silica gel activation;

[0056] (4): Immerse the silicone tube body of the catheter activated by the silica gel in step 3 into the glue prepared in step 1, add a certain amount of EDDQ or NHS, and maintain the chemical reaction for 15-20 minutes. The amount of EDDQ or NHS is the glue in step 1 1-2% of weight;

[0057] (5): After the reaction is completed, take out the catheter silicone tube body, wash it with purified water, and then immerse the catheter silicone tube body into polyhydroxyethyl ac...

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Abstract

The invention discloses a medicine-carrying nano antibacterial super-smooth coating for marine organisms. The medicine-carrying nano antibacterial super-smooth coating comprises a medicine-carrying nano antibacterial slow-release coating and a hydrophilic coating, wherein the medicine-carrying nano antibacterial slow-release coating comprises medicine-carrying nano particles and antibacterial substances; the medicine-carrying nano particles have effects of restraining and preventing bacteria and sustaining release, and have bacteria-inhibiting effects on escherichia coli, staphylococcus aureus, candida albicans and the like which cause urinary tract infection easily; the antibacterial substances further can improve the antibacterial effects of the medicine-carrying nano antibacterial slow-release coating, so that the medicine-carrying nano antibacterial slow-release coating achieves lasting and stable antibacterial effects; after contacting water, substances of the hydrophilic layer can quickly form a lubricating film, so that the conduit surface is sufficiently and efficiently lubricated, and the conduit is conveniently and quickly implanted; after the conduit is implanted, the hydrophilic polymer is dissolved into water to play synergetic bacteriostatic action with the medicine-carrying nano particles and the antibacterial substances, and the loaded bacteria-restraining components are slowly released to finally achieve the lasting and stable antibacterial effects.

Description

technical field [0001] The invention relates to a double-coating composed of a marine biological drug-loaded nano-antibacterial slow-release coating and a hydrophilic coating with antibacterial effects, in particular to a marine biological component composed of chitosan or chitosan and its derivatives. The drug-loaded nanometer antibacterial slow-release coating belongs to the technical field of medical devices. Background technique [0002] Catheter is a kind of interventional catheter, even if it is operated aseptically, it still cannot prevent urinary tract infection. Among the common infections in hospitals, urinary tract infections account for 35% to 50%, of which 75% to 80% are caused by catheters. In particular, long-term indwelling catheters account for 5% to 9% of nosocomial infections, which is clinically common. Concerns. The main reason for urinary tract infection caused by indwelling catheters is that tissue damage such as mucous membranes is very easy to occu...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/16A61L29/14A61M25/00
Inventor 李育强侯风君智倩倩韩超刘红梅
Owner 青岛高新区尚达医药研究所
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