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Montmorillonite external-application ointment for treating skin ulcer and preparation method and application thereof

A technology for skin ulcers and montmorillonite, applied in the field of medicine, can solve problems such as difficult healing of wounds, burn ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, postoperative ulcers, secondary bacterial infection, etc. to promote ulcer healing

Active Publication Date: 2015-07-08
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the raw materials, auxiliary materials and production conditions used in the preparation are not sterilized or the sterilization method is improper, it is easy to cause secondary infection in clinical practice, making it more difficult to heal the wound surface, resulting in unsatisfactory treatment effect or greater damage to the ulcer surface. harm
In addition, the montmorillonite external ointment medicine that is specially used in the treatment of skin ulcer (bedsore, scald ulcer, calf ulcer, postherpetic ulcer, diabetic ulcer, postoperative ulcer), particularly montmorillonite ointment preparation has not been reported yet

Method used

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  • Montmorillonite external-application ointment for treating skin ulcer and preparation method and application thereof
  • Montmorillonite external-application ointment for treating skin ulcer and preparation method and application thereof
  • Montmorillonite external-application ointment for treating skin ulcer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Embodiment 1, montmorillonite external ointment preparation and preparation

[0150] 1. The proportion of raw and auxiliary materials (w / w):

[0151]

[0152] 2. Preparation

[0153] (1) Take by weighing montmorillonite, polyethylene glycol 1000, glycerin, poloxamer 188, sorbitol, standby;

[0154] (2) Place the weighed montmorillonite in a dry heat sterilizer at a temperature of 250° C. for 120 minutes, and drop it to room temperature for subsequent use;

[0155] (3) Add montmorillonite into sterile water and stir evenly, continue to stir for 30 minutes to fully swell, then process the uniformly stirred mixture into a uniform gel with ultrasonic waves under stirring; ultrasonic frequency 32KHz, processing time 20 minutes;

[0156] (4) Add the weighed polyethylene glycol 1000, glycerin, poloxamer 188, and sorbitol into the dissolving tank with sterile water, start stirring and heat up until all are dissolved, continue to heat up to 135°C for sterilization, and keep ...

Embodiment 2

[0160] Embodiment 2, montmorillonite external ointment preparation and preparation

[0161] 1. The proportion of raw and auxiliary materials (w / w):

[0162]

[0163] 2. Preparation

[0164] (1) Take by weighing montmorillonite, polyethylene glycol 1000, glycerin, poloxamer 188, sorbitol, standby;

[0165] (2) Place the weighed montmorillonite in a dry heat sterilizer at a temperature of 350° C. for 120 minutes, and drop it to room temperature for subsequent use;

[0166] (3) Add montmorillonite into sterile water and stir evenly, continue to stir for 50 minutes to fully swell, then process the uniformly stirred mixture into a uniform gel with ultrasonic waves under stirring; ultrasonic frequency 45KHz, processing time 10 minutes;

[0167] (4) Add the weighed polyethylene glycol 1000, glycerin, poloxamer 188, and sorbitol into the dissolving tank with sterile water, start stirring and heat up until all are dissolved, continue to heat up to 140°C for sterilization, and keep...

Embodiment 3

[0171] Embodiment 3, montmorillonite external ointment preparation and preparation

[0172] 1. The proportion of raw and auxiliary materials (w / w):

[0173]

[0174]

[0175] 2. Preparation

[0176] (1) Take by weighing montmorillonite, polyethylene glycol 1000, glycerin, poloxamer 188, sorbitol, standby;

[0177] (2) Place the weighed montmorillonite in a dry heat sterilizer at a temperature of 300° C. for 120 minutes, and drop it to room temperature for subsequent use;

[0178] (3) Add montmorillonite into sterile water and stir evenly, continue to stir for 40 minutes to fully swell, then process the uniformly stirred mixture into a uniform gel with ultrasonic waves under stirring; ultrasonic frequency 40KHz, processing time 20 minutes;

[0179] (4) Add the weighed polyethylene glycol 1000, glycerin, poloxamer 188, and sorbitol into the dissolving tank with sterile water, start stirring and raise the temperature until all are dissolved, continue to heat up to 138°C f...

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Abstract

The invention relates to montmorillonite external-application ointment for treating skin ulcer and a preparation method and application thereof. The external-application ointment is prepared from the following raw materials in parts by mass: 50-80 parts of montmorillonite, 3-10 parts of polyethylene glycol 1000, 5-10 parts of glycerine, 5-10 parts of poloxamer 188, 20-40 parts of sorbitol and 500-800 parts of sterile water. According to the external-application ointment, montmorillonite is adopted as a pharmaceutic effective ingredient of the ointment disclosed by the invention, and montmorillonite and pharmaceutic adjuvants are subjected to processes, such as high-temperature dry-heat sterilization, moist-heat sterilization, dissolving, low-speed homogenizing, high-speed homogenizing, stirring, cooling and sterile filling, so as to prepare a medicinal preparation. The invention further provides application of the preparation in preparation of drugs for treating skin ulcer. Through skin external drug application, a relatively good clinical action on skin ulcers of different periods (bedsore, scald ulcers, shank ulcers, post-shingles ulcers, diabetic ulcers and postoperative ulcers) is shown.

Description

technical field [0001] The invention relates to a montmorillonite external ointment for treating skin ulcers, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Skin ulcer is one of the more common clinical complications, and its formation factors are various. Refractory ulcers are often caused by long-term uncontrolled primary diseases such as burns, scalds, and diabetes. It brings great pain to patients and seriously affects their quality of life. A body surface disease characterized by liquefaction, infection and necrosis of skin tissue defect, which does not heal for a long time after ulceration. Because the sore surface is difficult to heal and consumes a lot, it causes great psychological pressure and economic loss to the patient, and seriously affects the patient's health and quality of life. Chronic skin ulcers, also known as refractory ulcers, are more common in the elderly, especially those...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/06A61P17/02
Inventor 乔敏刘钢陈立宗李红新孟震晓
Owner SHANDONG SBOND PHARMA
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