A cefquinome sulfate oily suspension injection and a preparing method thereof

A cefquinome sulfate and oily suspension technology, which is applied in the field of medicine, can solve the problems of unstable content detection, poor dispersion, and easy precipitation, etc., to ensure the dosage and uniformity of the drug, good compatibility, and good needle penetration Effect

Active Publication Date: 2015-07-08
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are some suspension injection dosage forms in the prior art, but when they are compatible with oil-emulsion vaccines, there

Method used

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  • A cefquinome sulfate oily suspension injection and a preparing method thereof
  • A cefquinome sulfate oily suspension injection and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A cefquinoxime sulfate oily suspension injection, the 100ml injection comprises the following components: cefquinoxime sulfate 2.5g, BHT 0.1g, benzyl alcohol 1.0g, Tween-40 3.0g, Span-80 1.0 g, aluminum stearate 1.0 g, glycerol triabietate 0.3 g, ethyl oleate 60 g, and the balance is soybean oil for injection.

[0033] Its preparation method is:

[0034] 1) Add aluminum stearate to ethyl oleate, stir until uniformly dispersed, heat it to 120°C, at this time the solution system is clear and transparent, keep it for 30 minutes, cool down to 80°C, add BHT, after melting, Stir evenly, cool to room temperature, add benzyl alcohol and glycerol triabietate, stir evenly to form a mixed solution system;

[0035] 2) Add Tween-40 and Span-80 into the mixed solution system obtained in step 1), and stir evenly to obtain system A;

[0036] 3) Add cefquinome sulfate to a part of soybean oil for injection, adjust the gap between the stator and rotor of the colloid mill to 15 μm, and ...

Embodiment 2

[0040] A cefquinoxime sulfate oily suspension injection, the 100ml injection comprises the following components: cefquinoxime sulfate 10g, vitamin E 0.5g, benzyl alcohol 3.0g, Tween-40 3.0g, Span-80 2.0 g, 5.0 g of hydrogenated castor oil, 0.1 g of glycerol triabietate, 20 g of No. 10 white oil, 30 g of ethyl oleate, and the balance is soybean oil for injection.

[0041] 1) Mix No. 10 white oil and ethyl oleate evenly, add hydrogenated castor oil, stir evenly, then add vitamin E oil and benzyl alcohol, stir evenly, then add glycerol triabietin, stir evenly to form a solution system;

[0042] 2) Add Tween-40 and Span-80 to the resultant of step (a), and stir evenly to obtain system A;

[0043]3) Add cefquinome sulfate to some soybean oil for injection, adjust the gap between the stator and rotor of the colloid mill to 15 μm, and grind for 10 minutes to obtain system B;

[0044] 4) Add systems A and B into the mixing tank, stir and mix evenly, and make the volume to 100ml with ...

Embodiment 3

[0047] A cefquinoxime sulfate oily suspension injection, the 100ml injection comprises the following components: cefquinoxime sulfate 10.0g, BHT 0.5g, benzyl alcohol 1.0g, Tween-40 5.0g, Span-80 1.0 g, 2.0 g of aluminum stearate, 1.0 g of glycerol triabietate, 20 g of ethyl oleate, 20 g of diacetate, 10 g of No. 10 white oil, and the balance is soybean oil for injection.

[0048] Its preparation method refers to embodiment 1.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a cefquinome sulfate oily suspension injection and a preparing method thereof. 100 mL of the injection comprises following components: 0.1-10.0 g of cefquinome sulfate, 0.05-0.5 g of an antioxidant, 1.0-3.0 g of a bacteriostatic agent, 0.5-7.0 g of an emulsifying agent, 0.1-5.0 g of a suspending agent and 0.1-1.0 g of a thixotropic agent, with the balance being oil for injection. The preparing method includes following steps: dispersing the suspending agent into a part of the oil for injection, adding the antioxidant and the bacteriostatic agent in sequence, stirring, adding the emulsifying agent, and stirring to obtain a solution system; adding the cefquinome sulfate into a part of the oil for injection and grinding to obtain a solution system; mixing the two solution systems; adding the oil for injection until the total volume is 100 mL; and sterilizing. The injection has good compatibility with oil emulsion vaccines commonly used for livestock and poultry, and can be injected together, thus reducing working load. The injection is good in syringeability and obvious in slow release effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cefquinome sulfate oily suspension injection and a preparation method thereof. Background technique [0002] Cephalosporin antibiotics, also known as cephalosporins, are a class of broad-spectrum antimicrobial semi-synthetic antibiotics. They all have a β-lactam ring in their structure and belong to β-lactam antibiotics. Compared with penicillins, it has the characteristics of less toxicity, fewer allergic reactions, enhanced stability to acid and β-lactamase, and less hydrolysis, so it is more widely used in clinical practice. According to the discovery time of this class of drugs, they are divided into first, second, third, and fourth-generation cephalosporins. The first-generation cephalosporins are mainly cephalothin and cephalexin, which are mainly for Gram-positive bacteria. The effect is obvious, but it has certain toxicity to the kidneys, and the antibacte...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/14A61K47/22A61K47/34A61P11/00A61P31/04A61P31/16
Inventor 郭建军李凌峰管倩李会芳
Owner HENAN SOAR VETERINARY PHARMA
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