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Biomedical degradable absorption Mg-Sr-Cu alloy material, preparation method and application

A mg-sr-cu, biomedical technology, used in medical science, prosthesis, surgery, etc., to achieve high biosafety, promote osteoblast generation, and promote the regeneration of vascular endothelial cells.

Active Publication Date: 2015-07-08
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature or patent at home and abroad to propose that Mg-Sr-Cu alloys be used as biomedical materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～10

[0038] In Examples 1-10, the preparation method of the magnesium alloy is as follows:

[0039] (1) Weigh the raw materials pure magnesium, pure strontium and pure copper according to the ratio, wherein the purity of Mg is greater than or equal to 99.99wt%, the purity of strontium is greater than or equal to 99.999wt%, and the purity of copper is greater than or equal to 99.9wt%;

[0040] (2) drying the above materials in an oven at 90-110°C for 0.5-2 hours;

[0041] (3) Put pure magnesium in a low-carbon steel crucible, heat it in a resistance furnace at 710-730°C for 30-40 minutes, until the pure magnesium is completely melted;

[0042] (4) Heat the resistance furnace to 730-750°C, quickly add the dried pure strontium into the pure magnesium melt, stir once every 10 minutes, stir 3-5 times in total, and smelt for 40-60 minutes in total, Obtain solution A;

[0043] (5) Heat the resistance furnace to 750-780°C, add dried pure copper copper powder into solution A, stir once ev...

Embodiment 1

[0048] In this embodiment, the composition and weight percentage of the ternary Mg-Sr-Cu alloy material are: 0.5% Sr, 0.05% Cu, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight percentage, and the total amount is not more than 0.4%. The purity of the raw material Mg is greater than or equal to 99.99wt%, the purity of strontium is greater than or equal to 99.999wt%, and the purity of copper is greater than or equal to 99.9wt%. After 99~99.5% CO by volume 2 and 0.5~1.0%SF 6 (sulfur hexafluoride) high cleanliness melting and casting in protective atmosphere.

[0049] The material has good biocompatibility, and the cytotoxicity rating is 0. The degradation rate of this alloy is 0.1mm / year measured by weight loss test, and it can be degraded and absorbed in biological fluid or blood environment. Its tensile strength is 100MPa, the compressive strength is 200M...

Embodiment 2

[0051] In this embodiment, the composition and weight percentage of the ternary Mg-Sr-Cu alloy material are: 0.5% Sr, 0.1% Cu, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight percentage, and the total amount is not more than 0.4%. The purity of the raw material Mg is greater than or equal to 99.99wt%, the purity of strontium is greater than or equal to 99.999wt%, and the purity of copper is greater than or equal to 99.9wt%. After 99~99.5% CO by volume 2 and 0.5~1.0%SF 6 (sulfur hexafluoride) high cleanliness melting and casting in protective atmosphere.

[0052] The material has good biocompatibility, and the cytotoxicity rating is 0. The degradation rate of this alloy is 0.2mm / year measured by weight loss test, and it can be degraded and absorbed in biological fluid or blood environment. Its tensile strength is 140MPa, the compressive strength is 210MP...

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Abstract

The invention relates to the field of medical treatment of orthopaedic implantation, and in particular relates to a biomedical degradable absorption Mg-Sr-Cu alloy material, a preparation method and application. In terms of percentage by weight, the biomedical degradable absorption Mg-Sr-Cu alloy material comprises 0-10.0% of Sr, not including 0, 0-5.0% of Cu, not including 0, and the rest of Mg. A ternary magnesium alloy having good mechanical property, matched degrading property and multiple biomedical functions can be obtained by adjusting the content of Sr and Cu in a magnesium alloy and controlling the form, the number and distribution of the second phases in the magnesium alloy, such as Mg2Sr, Mg2Cu and CuSr and the release amount of Mg, Sr and Cu ions in body fluid. The biomedical degradable absorption Mg-Sr-Cu alloy material disclosed by the invention not only has good biocompatibility, and excellent property of matched mechanical property and corrosion degradation but also integrates multiple biochemical functions of resisting bacteria in a long-acting manner, promoting bone formation and vascularisation and the like; the infection probability of an implanted position is effectively reduced; the biological functions of osteoblasts and endothelial cells can be adjusted and controlled; the bone integration ability is increased; and the biomedical degradable absorption Mg-Sr-Cu alloy material has wide application prospect in the field of medical treatment of orthopaedic implantation and the like.

Description

technical field [0001] The invention relates to a biomedical degradable and absorbable Mg-Sr-Cu alloy material with antibacterial, osteogenic and vascularization-promoting functions and its preparation method and application, which is suitable as an implant material used in the human body environment, and is especially suitable for application In orthopedic implant medical field. Background technique [0002] Magnesium and magnesium alloys, as new biodegradable medical materials, have attracted close attention from biomaterial researchers and medical workers in recent years, and have become a research hotspot in the field of biomaterials. From a biological point of view, magnesium is an essential nutrient element for the human body, with a normal content of 25g in the human body, most of which exist in bones, teeth and soft tissues. Magnesium has a variety of physiological functions, participates in a series of metabolic processes in the body, acts as an activator of enzyma...

Claims

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Application Information

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IPC IPC(8): C22C23/00C22C1/02A61L27/04A61L27/54A61L27/58A61L31/02A61L31/16A61L31/14
Inventor 刘辰杨柯谭丽丽万鹏
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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