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A kind of hydrophilic rare earth ion doped nano-fluorescent body and its preparation method and application

A technology of rare earth ions and nano-fluorescence, which is applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of light scattering on the surface of nano-materials, weakened light absorption, weak fluorescence emission, etc., and achieve good application potential and good spectral performance.

Active Publication Date: 2016-08-24
惠州市松海新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the current application of nanoparticles in biomedicine is still in the preliminary stage of research, and the problems of biocompatibility and targeted delivery of nanoparticles have not been fully resolved. At the same time, the enhancement of light scattering on the surface of nanomaterials weakens light absorption and leads to fluorescence. The problem of weak emission, therefore, there are still many problems to be solved before the nanoparticles can be used in clinical trials

Method used

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  • A kind of hydrophilic rare earth ion doped nano-fluorescent body and its preparation method and application
  • A kind of hydrophilic rare earth ion doped nano-fluorescent body and its preparation method and application
  • A kind of hydrophilic rare earth ion doped nano-fluorescent body and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of Rare Earth Ion Doped Nanocrystals

[0054] 1. Preparation method

[0055] (1) Weigh 18.1250 g Gd 2 o 3 Dissolve in 21.0 mL of concentrated nitric acid, add water and stir to dissolve, then evaporate the volatile water to cool and crystallize, then dissolve in distilled water, and set the volume in a 100.00 mL volumetric flask to obtain 1.0 mol / L Gd(NO 3 ) 3 solution. Weigh 17.6000 g Eu 2 o 3Dissolve in 21.0 mL of concentrated nitric acid, add water and stir to dissolve, then evaporate the volatile water to cool and crystallize, then dissolve in distilled water, and set the volume in a 100.00 mL volumetric flask to obtain 1.0 mol / L Eu(NO 3 ) 3 solution.

[0056] (2) Dissolve 7.2894 g CTAB in a mixture of 50.0 ml cyclohexane and 10.0 mL n-butanol, stir vigorously, and add 2.97 mL Gd(NO 3 ) 3 and 0.03 mL Eu(NO 3 ) 3 solution (1.0 mol / L). Mix and ripen, let stand to make the precipitated crystal grow fully, let stand for 24 hours,...

Embodiment 2

[0059] Example 2 Preparation of Rare Earth Ion Doped Nanocrystals

[0060] 1. Preparation method

[0061] (1) Weigh 18.1250 g Gd 2 o 3 Dissolve in 21.0 mL of concentrated nitric acid, add water and stir to dissolve, then evaporate the volatile water to cool and crystallize, then dissolve in distilled water, and set the volume in a 100.00 mL volumetric flask to obtain 1.0 mol / L Gd(NO 3 ) 3 solution. Weigh 17.6000 g Eu 2 o 3 Dissolve in 21.0 mL of concentrated nitric acid, add water and stir to dissolve, then evaporate the volatile water to cool and crystallize, then dissolve in distilled water, and set the volume in a 100.0 mL volumetric flask to obtain 1.0 mol / L Eu(NO 3 ) 3 solution.

[0062] (2) Weigh 1.8224 g CTAB and 0.9112 g PVP and dissolve it in a mixture of 50.0 ml cyclohexane and 10.0 ml n-butanol, stir vigorously, and add 2.97 mL Gd(NO 3 ) 3 and 0.03 mL Eu(NO 3 ) 3 solution (1.0 mol / L). Mix and ripen, let it stand still to make the precipitated cryst...

Embodiment 3

[0065] Example 3 Preparation of Hydrophilic Rare Earth Ion Doped Nano Phosphors

[0066] 1. Preparation of rare earth ion doped nanocrystals

[0067] (1) Weigh 18.1250 g Gd 2 o 3 Dissolve in 21.0 mL of concentrated nitric acid, add water and stir to dissolve, then evaporate the volatile water to cool and crystallize, then dissolve in distilled water, and set the volume in a 100.00 mL volumetric flask to obtain 1.0 mol / L Gd(NO 3 ) 3 solution. Weigh 17.6000 g Eu 2 o 3 Dissolve in 21 mL of concentrated nitric acid, add water and stir to dissolve, then evaporate the volatile water to cool and crystallize, then dissolve in distilled water, and set the volume in a 100.00 mL volumetric flask to obtain 1.0 mol / L Eu(NO 3 ) 3 solution.

[0068] (2) Weigh 0.5025 g PVP and dissolve it in a mixture of 50.0 ml cyclohexane and 10.0 ml n-butanol, stir vigorously, and add 2.70 mL Gd(NO 3 ) 3 and 0.30 mL Eu(NO 3 ) 3 solution (1.0 mol / L) (where Eu 3+ The doping concentration i...

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Abstract

The invention discloses a hydrophilic rare earth ion-doped nano-fluorescent body, which comprises a luminescent center (trivalent rare earth ion Eu3+), a matrix Gd2O3 and a coating layer (modified D(+)-glucosamine hydrochloride) ; Among them, according to the amount of the total substance of Gd3+ ions before substitution, Eu3+ accounts for 1-20 at% of Gd3+ ions. The preparation method is to use CTAB and / or PVP as the surfactant, use nitrate, use the microemulsion method to synthesize the precursor hydroxide, grow and anneal to obtain the nano oxide, and then use the modified D(+)‑ Coated with glucosamine hydrochloride; the particle size of the product is more uniform, the shape is regular, it has strong absorption properties for X-rays, and it has good hydrophilicity and good biocompatibility; in addition, due to the two The introduction of affinity glucose will be phagocytized and enriched by sugar-loving cancer cells, which helps to achieve targeted transport and enrichment in vivo.

Description

technical field [0001] The invention belongs to the field of nano inorganic rare earth luminescent materials. More specifically, it relates to a hydrophilic rare earth ion-doped nano-phosphor and its preparation method and application. Background technique [0002] With the continuous research progress of nanotechnology in the field of biomedicine, nanobiomedical technology has shown broad application prospects in the field of medical applications. The recent research direction of nano-biomedical technology is mainly: on the one hand, using nano-technology for biomedical detection and disease diagnosis; on the other hand, using nano-technology for disease treatment. As an important field where nano-biomedical applications may have technological breakthroughs, the use of optical and magnetic properties of nanocrystals has shown good application prospects in the development of nano-targeted drugs. has 4 f n Rare earth ions with electronic structure have excellent optical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/78
Inventor 钟玖平黄玲玉
Owner 惠州市松海新材料科技有限公司
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