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Method for preparing mineral collagen coating on surface of medical implantation body

A technology for mineralizing collagen and implants, applied in the direction of electrolytic inorganic material coating, etc., can solve the problems of affecting the bonding force of the coating, hindering clinical application, large side effects of cathode deposition, etc. Foreground effect

Active Publication Date: 2015-07-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Negatively charged collagen will have relatively large side effects on cathode deposition, affecting the binding force of the coating, thus hindering clinical application

Method used

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  • Method for preparing mineral collagen coating on surface of medical implantation body
  • Method for preparing mineral collagen coating on surface of medical implantation body
  • Method for preparing mineral collagen coating on surface of medical implantation body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O was dissolved in water and prepared as Ca(NO 3 ) 2 aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 80mM 4 h 2 PO 4 aqueous solution, the Ca(NO 3 ) 2 Aqueous solution and NH 4 h 2 PO 4 The aqueous solution is stirred and mixed to obtain a calcium-phosphorus mixed solution. Dissolve Beiling liquid collagen in 0.005mol / L acetic acid, stir to form a collagen acetic acid solution with a collagen concentration of 0.5g / L, add the collagen acetic acid solution to the calcium-phosphorus mixed solution, and make the concentrations of calcium, phosphorus, and collagen respectively 8mmol / L, 8mmol / L, 0.4g / L, then use NH 3 ·H 2 O solution to adjust the pH of the electrolyte to 4.4.

[0020] The titanium plate after surface cleaning is used as the cathode, and the platinum electrode is used as the anode. The distance between the cathode and the anode is 1cm. Take ...

Embodiment 2

[0024] Preparation of electrolyte: CaCl 2 Dissolved in water, formulated as CaCl with a calcium concentration of 80mM 2 aqueous solution, the NaH 2 PO 4 Dissolved in water, prepared as NaH with a phosphorus concentration of 80mM 2 PO 4 aqueous solution, the CaCl 2 Aqueous solution and NaH 2 PO 4 The aqueous solution is stirred and mixed to obtain a calcium-phosphorus mixed solution. Dissolve Beiling liquid collagen in 0.005mol / L acetic acid, stir to form a collagen acetic acid solution with a collagen concentration of 0.5g / L, add the collagen acetic acid solution to the calcium-phosphorus mixed solution, and make the concentrations of calcium, phosphorus, and collagen respectively 8mmol / L, 8mmol / L, 0.4g / L, then use NH 3 ·H 2 O solution to adjust the pH of the electrolyte to 4.4.

[0025] The titanium plate after surface cleaning is used as the cathode, and the platinum electrode is used as the anode. The distance between the cathode and the anode is 1cm. Take 15ml of...

Embodiment 3

[0029] Preparation of electrolyte: Ca(NO 3 ) 2 ·6H 2 O was dissolved in water and prepared as Ca(NO 3 ) 2aqueous solution, the NH 4 h 2 PO 4 Dissolved in water, prepared as NH with a phosphorus concentration of 80mM 4 h 2 PO 4 aqueous solution, the Ca(NO 3 ) 2 Aqueous solution and NH 4 h 2 PO 4 The aqueous solution is stirred and mixed to obtain a calcium-phosphorus mixed solution. Dissolve Beiling liquid collagen in 0.005mol / L acetic acid, stir to form a collagen acetic acid solution with a collagen concentration of 0.5g / L, add the collagen acetic acid solution to the calcium-phosphorus mixed solution, and make the concentrations of calcium, phosphorus, and collagen respectively 10mmol / L, 10mmol / L, 0.4g / L, then use NH 3 ·H 2 O solution to adjust the pH of the electrolyte to 4.4.

[0030] The titanium plate after surface cleaning is used as the cathode, and the platinum electrode is used as the anode. The distance between the cathode and the anode is 1cm. Take...

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Abstract

The invention discloses a method for preparing a mineral collagen coating on the surface of a medical implantation body. An alternative potential method is adopted, and by adjusting parameters such as the deposition potential and the potential applying time, a modified layer which adopts a layered structure and is assembled from alternative strong and weak mineral collagen can be prepared on the surface of the metal implantation body. Due to alternative assembling of a strong mineral collagen layer and a weak mineral collagen layer, tight combination of a substrate and the coatings as well as the coatings can be achieved, and the coatings have certain toughness and are not easy to crack. In addition, the weak mineral collagen layer on the surface of the coating is beneficial to adhesion and proliferation of cells, and thus the method has wide application prospect in the field of hard bone tissue remediation.

Description

technical field [0001] The invention relates to a method for preparing a surface coating of a medical metal implant, in particular to a method for preparing a mineralized collagen coating on the surface of a medical metal implant. Background technique [0002] Natural bone consists of an inorganic phase, an organic phase and water. 60-70% of the inorganic phase is calcium phosphate minerals, and 90-95% of the organic phase is collagen. Therefore, the composition of collagen and calcium phosphate can be combined to obtain a composite material similar to the composition of natural bone, so it has good biocompatibility with human tissue. Titanium and titanium alloys are more and more widely used clinically due to their elastic modulus similar to that of bone, good biocompatibility, and excellent corrosion resistance in physiological environments. Therefore, the preparation of a layer of calcium phosphate and collagen composite material on the surface of the titanium metal sub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D5/18C25D9/04
Inventor 翁文剑庄均珺程逵王慧明林军
Owner ZHEJIANG UNIV
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