A kind of core-shell type gold nanomaterial and its preparation method and application

A nanomaterial, gold nanotechnology, applied in wave energy or particle radiation treatment materials, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as poor water solubility

Active Publication Date: 2017-06-06
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But hypocrellin is a hydrophobic drug, and its water solubility is not good. The fluorescence quantum yield of hypocrellin in water solubility is lower than that in non-polar solvent by more than an order of magnitude, so the concentration of hypocretin in water solubility is improved. Dispersion matters

Method used

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  • A kind of core-shell type gold nanomaterial and its preparation method and application
  • A kind of core-shell type gold nanomaterial and its preparation method and application
  • A kind of core-shell type gold nanomaterial and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1, the preparation of gold nanomaterial

[0086] 1. Preparation of gold nanorods (AuNRs)

[0087] 1. Gold seed preparation: 1.5ml of 0.01M cetyltrimethylammonium bromide (CTAB) and 50μl of 0.01M Au 3+ Mix and quickly add 120 μl of 0.01M NaBH 4 , shake, and place in a water bath at 28°C for 2-3 hours to obtain gold species.

[0088] 2. Preparation of AuNRs: Add 4ml of 0.01M Au to 80ml of 0.1M CTAB 3+ , under shaking, add AgNO 3 solution (0.01 M, 1 ml). Add 0.8ml of vitamin C (Vc, 0.01M) under shaking, after the color becomes colorless, shake for 1-2min, add 1ml of hydrochloric acid (HCl, 0.01M), adjust the pH value to 6-7, and finally add 200μl of Gold species (0.01M concentration). After reacting at 28°C for 24h, the obtained wine red solution was centrifuged at 10,000rpm for 10min, centrifuged twice, washed with deionized water, and excess CTAB was removed to obtain AuNRs with a length of 60-80nm, such as figure 1 (a) shows the TEM image of AuNRs.

...

Embodiment 2

[0101] Embodiment 2, the application of gold nanomaterial

[0102] 1. Using AuNRs@MSN-HB@Lipid and AuNRs@MSN-HB prepared by the method in Example 1 of the present invention, the same amount of the above two nanoparticles was added to breast cancer cells (MCF-7) Carry out culture, measure the content of nanoparticle phagocytosis in different time (0~9h, specifically can be 1,3,6,9h), and its result is as follows: Figure 4 Shown is the change of the content of gold element inside the cells with time after the cells phagocytized the nanoparticles at different times. Depend on Figure 4 It can be seen that by comparing the content of gold elements in the cells in different time periods, it is proved that the liposome layer is helpful for the endocytosis of the cells.

[0103] 2. Disperse the AuNRs@MSN-HB@Lipid nanoparticles prepared by the method in Example 1 of the present invention into the aqueous solution and configure them into different concentrations. Laser irradiation ...

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Abstract

The invention discloses a core-shell gold nanometer material, a preparation method and an application thereof. It consists of gold nanorods, mesoporous silica coated on gold nanorods, photosensitizer adsorbed in mesoporous silica and liposomes adsorbed on the surface of mesoporous silica. The preparation method is as follows: gold nanorods are coated with mesoporous silica to obtain gold nanorods coated with mesoporous silica; then the gold nanorods coated with mesoporous silica are mixed with photosensitizer methanol solution and adsorbed to obtain Mesoporous silicon dioxide-coated gold nanorods that absorb photosensitizers; then mix with liposome solution and absorb to obtain. The invention is applied in the preparation of a drug for treating tumors, and the drug is composed of a core-shell type gold nanometer material and auxiliary materials. The present invention effectively combines gold nanoparticles with photothermal therapy effects with photosensitizers that absorb in the near-infrared region, which can not only rapidly accumulate in cancer cells; but also realize the combination of photothermal therapy and photodynamic therapy under two-photon irradiation Pharmaceutical preparation applications.

Description

technical field [0001] The invention relates to a core-shell type gold nano material and its preparation method and application, belonging to the field of nano material preparation. Background technique [0002] Gold nanorods are rod-shaped gold nanoparticles with a size ranging from a few nanometers to hundreds of nanometers. Because the surface plasmon resonance wavelength (550nm-1550nm) of gold nanorods changes with the aspect ratio of gold nanorods, it has a very high surface electric field intensity enhancement effect and adjustable photothermal conversion efficiency. Due to their unique optical, photoelectric, photothermal and biological properties, gold nanorods have received great attention in photothermal therapy. However, gold nanorods are easy to aggregate in vivo, which affects the surface plasmon resonance wavelength. [0003] According to the regulations of the International Union of Pure and Applied Chemistry (IUPAC), mesoporous materials refer to a class of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K41/00A61K9/14A61K47/02A61K31/337A61K31/704A61P35/00
Inventor 李峻柏秦晨晨费进波王安河
Owner INST OF CHEM CHINESE ACAD OF SCI
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