Oral gel for relief of tooth pain

A gel and tooth technology, applied in the field of oral gel for alleviating tooth pain, can solve the problems of not being able to identify the cause of the pain, not having immediate effects, not being able to obtain and the like

Active Publication Date: 2015-08-12
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without a dental examination, the patient may not be able to identify the cause of the pain
Current symptomatic treatment includes medicinal pain relievers (NSAIDs such as aspirin, ibuprofen, or acetaminophen), topical gel anesthetics containing lidocaine or benzocaine, and/or anesthetics such as codeine, but these drugs each have their ...

Method used

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  • Oral gel for relief of tooth pain
  • Oral gel for relief of tooth pain
  • Oral gel for relief of tooth pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Prepare the gel using the following ingredients:

[0056]

[0057]

[0058]

[0059]

[0060]Briefly, the carbomer was dispersed in propylene glycol and water, stirred; the surfactant, sweetener, and preservative were then premixed, added, and stirred. The oil blend is then added and the mixture is homogenized. Base is added last, which raises the pH of the mixture and causes the carboxylate groups on the carbomer to ionize, resulting in a thick gel. The above formulations were prepared with different amounts of oil components, the properties of the formulations were observed, and the formulations were applied to the teeth and gums of volunteers:

[0061]

[0062] While none of the formulations were completely unacceptable, the 5% blend appeared to be stable despite the higher oil level, providing good delivery of effective levels of active agent.

[0063] Optimization of Oil Blend Composition : The above 5% oil formulation was then varied using diffe...

Embodiment 2

[0068] The compositions of the present invention can be prepared according to the following methods:

[0069] 1. Disperse Carbopol 974P NF in the formulated amount of propylene glycol and one part water.

[0070] 2. Using a homogenizer, ensure uniform dispersion and wetting of Carbopol in the propylene glycol and water blend.

[0071] 3. Avoid very high agitation to prevent air entrapment and large lump formation.

[0072] 4. Add the formulated amounts of Poloxamer 407, Polysorbate 20, Sodium Saccharin and Sodium Benzoate to the remaining quantity of water.

[0073] 5. In a mixer, mix all ingredients together on low speed.

[0074] 6. Continue mixing until a uniform dispersion is obtained.

[0075] 7. After ensuring that the two blends are uniformly dispersed, add the polymer dispersion to the poloxamer dispersion in the mixer.

[0076] 8. Allow to mix until a smooth homogeneous dispersion is obtained.

[0077] 9. Add the formulated amount of the oil blend to the dispersi...

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PUM

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Abstract

Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor; in an orally acceptable gel base, the gel base providing controlled release of the mixture of analgesic oils following application to a tooth; together with methods of making and using the same.

Description

Background of the invention [0001] Dental pain is most commonly caused by structural damage to the tooth where the nerves of the tooth, usually well protected by dentin and enamel, are exposed to external stimuli, for example as a result of caries, cracked teeth, exposed roots, or erosion of the tooth enamel , and from gum disease, abscesses, or collisions. The severity of toothache can range from chronic and mild to acute and excruciating. Pain can be worsened by chewing or cold or heat. Without a dental examination, the patient may not be able to identify the cause of the pain. Current symptomatic treatment includes medicinal pain relievers (NSAIDs such as aspirin, ibuprofen, or acetaminophen), topical gel anesthetics containing lidocaine or benzocaine, and / or anesthetics such as codeine, but each of these drugs has its own limitations in that they may not be available without a prescription, may not have immediate effects, and / or may have undesired side effects. Home re...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61Q11/00A61K47/34A61K36/61A61K31/125
CPCA61K8/922A61K8/34A61K8/35A61K8/042A61K31/085A61Q11/00A61K9/0053A61K47/34A61K36/61A61K31/125A61K8/347A61P1/02A61P25/04A61P29/00A61K2300/00
Inventor S.波特尼斯R.苏布拉曼亚姆R.奈尔
Owner COLGATE PALMOLIVE CO
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