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Traditional Chinese medicine coating agent for preventing and treating piglet diarrhea and preparation method thereof

A technology of piglet diarrhea and film-coating agent, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, antiviral agents, etc., can solve the problems of poor palatability and poor efficacy of drugs, and achieve the purpose of improving immunity, drug Fast absorption, solve the effect of strong medicinal taste

Inactive Publication Date: 2017-12-29
DALIAN NATIONALITIES UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of poor palatability and poor drug efficacy of existing oral Chinese medicines for treating piglet diarrhea, the invention provides a traditional Chinese medicine film-coating agent for preventing piglet diarrhea and a preparation method thereof. The Chinese medicine film-coating agent can be directly applied to the navel of piglets Drug ingredients can be absorbed in the site, quick effect, no drug residue, low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Weigh 18 parts of Atractylodes macrocephala, 25 parts of plantago seed, 10 parts of woody fragrance, 8 parts of Huoxiang, 7 parts of licorice, 15 parts of Smilax chinensis, 13 parts of Scutellaria baicalensis, 25 parts of astragalus, and crush the raw materials to 120 mesh , put into water with 15 times the mass of each raw material and cook on high heat for 2 hours, and then heat and reflux in 60vt% ethanol at a concentration of 5 times the mass of each raw material to extract 3 times at a temperature of 60°C. Liquid is filtered with filter paper, is mixed with each Chinese medicine fluid extract of 1:1, promptly every 1g raw material obtains 1ml fluid extract;

[0033] (2) Mix each Chinese medicine liquid extract prepared in step (1), collect the supernatant after centrifuging at 1800r / min for 30min, concentrate the supernatant into a mixed liquid extract of 2:1, and set aside;

[0034](3) Polyvinyl alcohol, chitosan and sodium alginate are respectively dissolved ...

Embodiment 2

[0038] (1) Weigh 20 parts of Atractylodes macrocephala, 30 parts of plantago seed, 15 parts of woody fragrance, 10 parts of Huoxiang, 10 parts of licorice, 20 parts of Smilax chinensis, 15 parts of Scutellaria baicalensis, 30 parts of astragalus, and crush the raw materials to 120 mesh , put into water with 15 times the mass of each raw material and cook for 3 hours on high heat, then heat and reflux extract 3 times in 75vt% ethanol at a concentration of 6 times the mass of each raw material after boiling, the extraction temperature is 65°C, and each extract Filter with filter paper, be mixed with each Chinese medicine fluid extract of 1:1, promptly every 1g raw material obtains 1ml fluid extract;

[0039] (2) Mix each Chinese medicine liquid extract prepared in step (1), collect the supernatant after centrifuging at 2000r / min for 20min, concentrate the supernatant into a mixed liquid extract of 2:1, and set aside;

[0040] (3) Polyvinyl alcohol, chitosan and sodium alginate a...

Embodiment 3

[0044] (1) Weigh 30 parts of Atractylodes macrocephala, 35 parts of Plantaginaceae, 25 parts of woody fragrance, 15 parts of Huoxiang, 15 parts of licorice, 22 parts of Smilax chinensis, 18 parts of Scutellaria baicalensis, and 33 parts of Astragalus membranaceus, and crush the raw materials to 120 mesh , put into water with 20 times the mass of each raw material and cook on high heat for 4 hours, then heat and reflux extract 3 times in 65vt% ethanol at a concentration of 5 times the mass of each raw material after boiling, the extraction temperature is 63°C, and each extract Filter with filter paper, be mixed with each Chinese medicine fluid extract of 1:1, promptly every 1g raw material obtains 1ml fluid extract;

[0045] (2) Mix each Chinese medicine liquid extract prepared in step (1), collect the supernatant after centrifuging at 2000r / min for 20min, concentrate the supernatant into a mixed liquid extract of 2:1, and set aside;

[0046] (3) Polyvinyl alcohol, chitosan and...

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PUM

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Abstract

The invention provides a traditional Chinese medicine film-coating agent for preventing and treating piglet diarrhea and its preparation method and application, which belong to the field of veterinary medicine. Fragrance, licorice, Smilax cocos, Scutellaria baicalensis and Radix Astragali are used as raw materials, which are crushed, boiled, filtered, extracted, and then concentrated into liquid extract, which is prepared by uniformly mixing the liquid extract with film-forming solution and skin penetration accelerator Chinese medicine coating agent. The product of the present invention can be directly coated on the navel of piglets, can effectively improve the drug absorption effect, and has quick results. The best cure rate of piglet diarrhea can reach 90.0%, achieving a good therapeutic effect. It is non-irritating to the skin and has antibacterial, It has the advantages of anti-inflammatory, no residue, etc.; the preparation process is simple and easy, the cost is low, and it is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and in particular relates to a traditional Chinese medicine coating agent for preventing and treating piglet diarrhea and a preparation method thereof. Background technique [0002] Diarrhea is the most common disease in piglets. Since 2014, the epidemic of piglet diarrhea has occurred in the United States, and nearly 6 million piglets have died. Later, diarrhea epidemics have also occurred in many places. Recently, epidemic diarrhea ransacked Japanese farms again, killing nearly 70,000 pigs. In the face of the epidemic sweeping the world, countries are stepping up the development of drugs against piglet diarrhea. [0003] Piglet epidemic diarrhea is an acute intestinal infectious disease of pigs caused by porcine epidemic diarrhea virus, which is characterized by watery diarrhea, vomiting and dehydration. It is sensitive to ether, chloroform, etc., and has weak resistance to the external enviro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/896A61K9/70A61P1/12A61P31/14
Inventor 杜雄伟李叶邹民发王玉山梁军陈朝喜
Owner DALIAN NATIONALITIES UNIVERSITY