Process for extracting chlorogenic acid and dye from honeysuckle leaf

A technology of honeysuckle leaves and chlorogenic acid is applied in the fields of honeysuckle extraction of chlorogenic acid and honeysuckle chlorophyll, tannin pigment dyes, development and reuse of Chinese herbal medicine plants, and flavonoids, which can solve the problems of large hidden dangers and isomerization of chlorogenic acid. Loss, energy consumption and other problems, to achieve the effect of slow resin separation, solve instability problems, and improve yield and quality

Inactive Publication Date: 2015-08-19
山东禾本堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyamide column chromatography and macroporous resin adsorption are slow and inefficient
Ultrasonic-assisted method has ultrasonic noise pollution that affects the health of operators
There are many hidden dangers in the high pressure of CO2 supercritical method
Moreover, the pre-extraction methods such as stone mercaptan method, lead precipitation method, polyamide column chromatography, and macroporous resin adsorption method usually adopt high-temperature cooking to double-effect concentration, which not only consumes a lot of energy, but also causes some chlorogenic acids to be metabolized. structural damage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take the fresh leaves of honeysuckle—cleaning—hot air drying at 45°C~55°C—crushing to 40~60 mesh—extraction with ethanol pure water mixed solvent at 25°C~55°C—microfiltration to remove impurities and bacteria—ultrafiltration to intercept the concentrated solution in vacuum and dry with ethanol Water reuse—nanofiltration intercepts the concentrated solution and vacuum-dries it, and ethanol pure water for reuse.

Embodiment 2

[0016] Take the fresh leaves of honeysuckle—cleaning—hot air drying at 47°C~53°C—crushing to 42~58 mesh—extraction with ethanol pure water mixed solvent at 27°C~53°C—microfiltration to remove impurities and bacteria—ultrafiltration to intercept the concentrated solution in vacuum and dry with ethanol Water reuse—nanofiltration intercepts the concentrated solution and vacuum-dries it, and ethanol pure water for reuse.

Embodiment 3

[0018] Take the fresh leaves of honeysuckle—cleaning—hot air drying at 49°C~51°C—crushing to 44~6 meshes—extraction with ethanol pure water mixed solvent at 29°C~50°C—microfiltration to remove impurities and bacteria—ultrafiltration to intercept the concentrated solution in vacuum and dry it with ethanol Water reuse—nanofiltration intercepts the concentrated solution and vacuum-dries it, and ethanol pure water for reuse.

[0019] The low-temperature operation process of the present invention solves the instability problem of chlorogenic acid at high temperature and improves the yield and quality of chlorogenic acid.

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PUM

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Abstract

The present invention discloses a process for extracting chlorogenic acid and a dye from honeysuckle leaf, wherein medicinal chlorogenic acid, flavones for dyeing, tannins for dyeing, and chlorophyll for dyeing are mixed with a mixed polar solvent comprising ethanol and water according to a ratio of 1:4 by using honeysuckle leaf, extraction is performed at a low temperature of 25-55 DEG C, and impurity bacteria removal with micro-filtration according to mass grading tubes, ultra-filtration nano-filtration separation, concentration, and low temperature vacuum drying are sequentially performed to respectively obtain the honeysuckle drug raw material chlorogenic acid and the honeysuckle leaf plant standard ultrafine powder dye. According to the present invention, the process is the low temperature operation process, such that the problem that the chlorogenic acid is generally instable at the high temperature is solved, and the yield and the quality of the chlorogenic acid are improved.

Description

technical field [0001] The invention relates to medicinal ingredients of Chinese herbal medicines and plant dyes of Chinese herbal medicines, in particular to a process for extracting chlorogenic acid, chlorophyll, flavonoids and tannin pigment dyes from honeysuckle flowers, which belongs to the development and reuse of Chinese herbal medicine plants. Background technique [0002] Since ancient times, my country has used plants to treat diseases and use plants to dye for thousands of years. With the development of modern science and technology, people have already known the components, structures and pharmacological properties of plants. Honeysuckle has been a good medicine for clearing away heat, detoxifying and sterilizing bacteria since ancient times, and its main medicinal ingredient is honeysuckle chlorogenic acid. Honeysuckle usually only uses part of the flower buds for medicine or only extracts the medicinal component chlorogenic acid, while a large number of leaves...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48C09B61/00C07D487/22C07H13/08C07H1/08
CPCC07C67/48C07C2601/14C07D487/22C07H1/08C07H13/08C09B61/00C09B67/0096C07C69/732
Inventor 袁慧丽
Owner 山东禾本堂生物科技有限公司
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