Miniaturized probe-type multiple-photon endoscope probe

Abstract

The invention relates to a miniaturized probe-type multiple-photon endoscope probe. The miniaturized probe-type multiple-photon endoscope probe comprises a hollow-core double-cladding pohotonic crystal fiber which can simultaneously transmit an ultrashort pulse excitation light source and excitation signal, a two-layer piezoelectric actuator, a gradient refraction index lens assembly composed of a delay lens and an objective lens and a medical probe body, and therefore imaging in the tissue depth portion can be achieved through the miniaturized probe-type multiple-photon endoscope probe. According to the miniaturized probe-type multiple-photon endoscope probe, the design of the probe integrates the optical fiber technology, the gradient refraction index lens technology and the probe technology, ultrashort pulse excitation light is transmitted to one end of the gradient refraction index lens assembly through the hollow-core double-cladding pohotonic crystal fiber, the two-layer piezoelectric actuator drives an optical fiber cantilever to achieve two-dimensional scanning, then the excitation light is focused on the front focal plane of the objective lens, the medical probe body guides the gradient refraction index lens assembly to penetrate into the tissue interior to achieve the focus of the deep tissue, excited signal light is collected through the objective lens of the gradient refraction index lens assembly, and then an image of the tissue depth portion is obtained.

Description

technical field [0001] The patent of the present invention relates to the field of medical equipment, in particular to a miniaturized probe probe of a medical multiphoton endoscope. Background technique [0002] Multiphoton microscopy is based on nonlinear optical effects such as harmonics and multiphoton excitation fluorescence generated by the interaction between femtosecond laser and biological tissue. Because it uses near-infrared ultrashort femtosecond pulse laser as the excitation light source, the interaction between laser and tissue Occurring within a femtoliter volume gives this technique unique advantages such as low photodrifting, low phototoxicity, and photosection capabilities for living tissues. Since many internal components of biological tissues can generate strong autofluorescence and harmonic signals without external molecular probes, the application of this technology in clinical medical photodiagnosis, therapeutic evaluation and microsurgery has attracted...

AI Technical Summary

Problems solved by technology

Although some multiphoton endoscope probes are designed to be small enough to be used through the working channels of conventional colonoscopes, gastroscopes and laparoscopes, the imaging of tissues is limited to the surface of the tissues

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