Furoate glucoside analogue 1 and purpose thereof of using as alpha-glycosidase inhibitor

A technology of analogs and furoate, applied in the field of α-glucosidase inhibitors, can solve problems such as flatulence and diarrhea, and cumbersome synthesis steps
CN104861006AInactive Publication Date: 2015-08-26JILIN AGRICULTURAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN AGRICULTURAL UNIV
Publication Date
2015-08-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention refers to the field of traditional Chinese medicine, and especially relates to furoate glucoside analogue 1 and purpose thereof of using as alpha-glycosidase inhibitor. The structure of the furoate glucoside analogue 1 is 3-(furan-2-methylcarbonyl)oxyglucopyranose aldehyde acid-1 alpha-4-D-glucopyranose-1 alpha -4-D-glucopyranose. The furoate glucoside analogue 1 has strong inhibition ability to alpha-glucosidase, and can be further developed to be drugs for treating and assisting the treatment of 2 type diabetes.
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Description

technical field

[0001] The invention relates to the field of traditional Chinese medicine, in particular to an alpha-glucosidase inhibitor. Background technique

[0002] Diabetes mellitus (diabetes mellitus) is a chronic disease of carbohydrate, fat and protein metabolism disorder caused by relative or absolute deficiency of insulin in the body or decreased sensitivity of target cells to insulin, or structural defects of insulin itself. Its main features are hyperglycemia and diabetes. It is clinically manifested as polydipsia, polyphagia, polyuria, and weight loss (i.e. "three excesses and one less"), which can cause morphological structural changes and dysfunction in some tissues or organs, accompanied by ketoacidosis, limb gangrene, multiple Neuritis, blindness and renal failure. The disease incidence rate is increasing day by day, and has become a worldwide common disease and frequently-occurring disease.

[0003] According to the Asian Diabetes Society, as of 2012, t...

Claims

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