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Composite medical film and preparation method thereof

A film and low-density polyethylene technology, which is applied in the field of composite medical film and its preparation, can solve the problems of low biocompatibility and application limitations, and achieve the effect of excellent mechanical properties and good biocompatibility

Inactive Publication Date: 2015-09-02
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its biocompatibility is not high, and its application in the medical field is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A composite medical film, comprising the following components in parts by weight: 50 parts of low-density polyethylene, 20 parts of chitosan, 0.5 part of suberone, 0.5 part of 3-hydroxy-4-methoxybenzoic acid, and 0.1 part of protrol, 0.1 part of quercetin, 0.1 part of 2,7-anhydro-β-D-altroheptanone pyranose, 0.1 part of silicon dioxide, 0.1 part of antioxidant 168, dicumyl peroxide 0.1 part and 1 part of hexadecylphosphonium chloride.

[0022] The preparation method of composite medical film comprises the steps:

[0023] (1) Weigh each component by weight;

[0024] (2) Put each component into the reaction kettle, heat to 90°C in a nitrogen atmosphere, stir continuously at a speed of 250r / min, and react for 2 hours to obtain a pre-finished product;

[0025] (3) Feed the pre-finished product prepared in step (2) into a twin-screw extruder with an extrusion temperature of 240°C and a screw speed of 35~50Hz. The twin-screw extruded strips are water-cooled, air-dried, and ...

Embodiment 2

[0028] A composite medical film, comprising the following components in parts by weight: 53 parts of low-density polyethylene, 23 parts of chitosan, 0.8 part of suberone, 0.8 part of 3-hydroxy-4-methoxybenzoic acid, and 0.2 parts of protrol, 0.2 parts of quercetin, 0.2 parts of 2,7-anhydro-β-D-altroheptanone pyranose, 0.2 parts of silicon dioxide, 0.2 parts of antioxidant 168, dicumyl peroxide 0.2 parts and 2 parts of hexadecylphosphonium chloride.

[0029] The preparation method of composite medical film comprises the steps:

[0030] (1) Weigh each component by weight;

[0031] (2) Put each component into the reaction kettle, heat to 95°C in a nitrogen atmosphere, stir continuously at a speed of 220r / min, and react for 2 hours to obtain a pre-finished product;

[0032] (3) Feed the pre-finished product prepared in step (2) into a twin-screw extruder with an extrusion temperature of 245°C and a screw speed of 35~50Hz. The twin-screw extruded strips are water-cooled, air-drie...

Embodiment 3

[0035] A composite medical film, comprising the following components in parts by weight: 55 parts of low-density polyethylene, 25 parts of chitosan, 1 part of suberone, 1 part of 3-hydroxy-4-methoxybenzoic acid, and 0.2 parts of protrol, 0.2 parts of quercetin, 0.2 parts of 2,7-anhydro-β-D-altroheptanone pyranose, 0.3 parts of silicon dioxide, 0.2 parts of antioxidant 168, dicumyl peroxide 0.2 parts and 3 parts of hexadecylphosphonium chloride.

[0036] The preparation method of composite medical film comprises the steps:

[0037] (1) Weigh each component by weight;

[0038] (2) Put each component into the reaction kettle, heat to 100°C in a nitrogen atmosphere, stir continuously at a speed of 200r / min, and react for 2.5h to obtain a pre-finished product;

[0039] (3) Feed the pre-finished product prepared in step (2) into a twin-screw extruder at an extrusion temperature of 250°C and a screw speed of 35~50Hz. The twin-screw extruded strips are water-cooled, air-dried, and p...

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Abstract

The invention provides a composite medical film and a preparation method thereof. The composite medical film comprises the following components: low-density polyethylene, chitosan, friedelin, 3-hydroxyl-4-methoxybenzoic acid, kaempferol, quercetin, 2,7-dehydrate-beta-D- altroheptulo pyranoses, silicon dioxide, an antioxidant, a cross-linking agent and an antibacterial agent. The preparation method comprises the following steps: weighing all the components in parts by weight, feeding the components into a reaction kettle, heating in a nitrogen atmosphere, and continuously stirring to react, thereby obtaining a prefinished product; extruding the prefinished product in a double-screw extruder, thereby obtaining master batch; performing extrusion film blowing on the master batch in a plastic film blowing machine, thereby obtaining the composite medical film. The composite medical film provided by the invention is excellent in mechanical property, also good in biocompatibility, free of irritation to skin and just like normal saline, the tensile strength of the composite medical film is greater than 22MPa, and the steam permeation rate of the composite medical film is smaller than 3*10<-14>*(kg.m / (m<2>.s.Pa)).

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a composite medical film and a preparation method thereof. Background technique [0002] Medical equipment packaging film has great market potential, and medical equipment has high requirements for packaging film. It not only needs to ensure the flexibility, formability and good heat sealing strength of the film, but also considers its barrier to bacteria and puncture resistance. It can ensure the stability of the content in a sterile environment, heat resistance and hygienic properties such as no migration of harmful substances, as well as environmental friendliness. Based on this, people are actively researching various new materials for medical equipment packaging to meet the multi-faceted and multi-level performance requirements of surgical medical equipment. [0003] LLDPE is widely used in the manufacture of films due to its high tensile strength, good puncture and tear ...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08L23/06C08L5/08C08L79/04C08K13/02C08K5/09C08K3/36C08K5/524C08K5/50C08K5/14B29C49/78
Inventor 李苏杨徐勤霞李文遐
Owner SUZHOU BEC BIOLOGICAL TECH
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