Macromolecule solid micro needle and batched preparing method thereof

A polymer and polymer material technology, applied in the field of polymer solid microneedles and their batch preparation, can solve the problems of human body damage, broken skin, and increased risk of microneedle use, and achieve good durability, low price, The effect of simple preparation process

Inactive Publication Date: 2015-09-09
BEIJING UNIV OF CHEM TECH
View PDF14 Cites 22 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the development of these devices has great use value, the preparation technology of such metal or silicon microneedle devices is not mature enough and their microstruc

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Macromolecule solid micro needle and batched preparing method thereof
  • Macromolecule solid micro needle and batched preparing method thereof
  • Macromolecule solid micro needle and batched preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1) Mix polydimethylsiloxane and aminoethylpiperazine curing agent at a mass ratio of 10:1, stir well and vacuumize to remove air bubbles, then place them in a horizontal container and place them in an oven at 60°C Heating in a medium temperature for 8 hours to obtain solid polydimethylsiloxane, then take it out from the container, and use laser cutting and micro-nano processing technology to prepare micro-needle molds;

[0035] 2) Fix the microneedle mold on the bottom plate of the preparation device, then place polylactic acid particles on the microneedle mold, and then place the entire preparation device in a closed heating device to heat until the particles melt, and the heating temperature is 180°C;

[0036] 3) The preparation device is taken out from the closed heating device, and the melt of polylactic acid is molded while hot through the preparation device;

[0037] 4) cooling the preparation device to room temperature, and then demoulding through the preparation...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Heightaaaaaaaaaa
Spacingaaaaaaaaaa
Bottom diameteraaaaaaaaaa
Login to view more

Abstract

The invention belongs to the technical field of administration equipment, and relates to a macromolecule solid micro needle and a batched preparing method thereof. The macromolecule solid micro needle is composed of a base and needle body arrays distributed on the base. The height of each needle body in each needle body array is 200-900 microns, the distance between needle points is 200-600 microns, and the diameter of the bottom of each needle body is 30-800 microns. The size of each needle body array is 5 mm*5 mm to 10 cm*10 cm. Compared with the prior art, the macromolecule solid micro needle solves the key problems that in the current beautifying nutrient substance and medicine transdermal releasing technology, due to the shielding function of the cuticle in the skin cuticular layer, the substance transdermal absorption is difficult, and a human body can feel painful and discomfortable. Thus, the macromolecule solid micro needle is good in durability and low in cost, the manufacturing technology of the macromolecule solid micro needle is simple, and the macromolecule solid micro needle is suitable for batched production.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to a polymer solid microneedle and a batch preparation method thereof. Background technique [0002] At present, most drugs can be made into multiple preparations and administered through different routes and methods of administration. The route and method of administration affect the drug metabolism, thereby affecting the curative effect. Compared with non-invasive methods such as oral administration or topical administration, injection administration has its irreplaceable advantages. Injection includes subcutaneous injection and intravenous infusion. Taking intravenous injection as an example, it can directly deliver the drug into the blood, and the drug will reach the lesion along with the blood circulation. Compared with oral administration, which uses the digestive tract to absorb the drug, it has a faster speed and higher drug utilization. Not on...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61M37/00A61L31/14
Inventor 郭新东李秋玉
Owner BEIJING UNIV OF CHEM TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap