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A kind of diosmin tablet and preparation process thereof

A technology for diosmin tablets and osmin tablets, which are applied in the field of pharmaceutical preparations, can solve the problems of investigation, small drug loading, inconvenient use and the like, and achieve good content uniformity, rapid drug dissolution, and preparation technology. simple effect

Active Publication Date: 2017-10-03
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that it exists is that the drug load is small and it is inconvenient to use compared with oral tablets (Jin Weihua et al., Preparation and content determination of diosmin cream, Chinese Pharmacy, Volume 23, No. 29, 2012)
This technology does not investigate the particle size of the raw material, nor does it verify the in vitro dissolution effect of the preparation

Method used

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  • A kind of diosmin tablet and preparation process thereof
  • A kind of diosmin tablet and preparation process thereof
  • A kind of diosmin tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024]

[0025] Preparation Process:

[0026] ① Add diethylene glycol monoethyl ether to absolute ethanol, stir evenly, add diosmin and stir to mix evenly, dry under reduced pressure at 40°C to remove absolute ethanol;

[0027] ② Weigh kaolin and add it to the mixture of diosmin and diethylene glycol monoethyl ether, mix and absorb, pass through a 20-mesh sieve, add microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate and mix evenly. ΦPunching tablet: 12mm punching tablet, control the hardness to 100-120N.

Embodiment 2

[0029]

[0030] Preparation Process:

[0031] ① Add diethylene glycol monoethyl ether to absolute ethanol, stir well, add diosmin and stir to mix evenly, dry under reduced pressure at 40°C to remove absolute ethanol;

[0032] ② Weigh kaolin and add it to the mixture of diosmin and diethylene glycol monoethyl ether, mix and absorb, pass through a 20-mesh sieve, add lactose, crospovidone, and sodium stearate fumarate and mix evenly. ΦPunching tablet: 12mm punching tablet, control the hardness to 100-120N.

Embodiment 3

[0034]

[0035]

[0036] Preparation Process:

[0037] ① Add diethylene glycol monoethyl ether to absolute ethanol, stir well, add diosmin and stir to mix evenly, dry under reduced pressure at 40°C to remove absolute ethanol;

[0038] ② Weigh kaolin and add it to the mixture of diosmin and diethylene glycol monoethyl ether, mix and absorb, pass through a 20-mesh sieve, add microcrystalline cellulose, croscarmellose sodium, and magnesium stearate Mix evenly, press the Φ tablet into a 12mm punched tablet, and control the hardness to 100-120N.

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Abstract

The invention discloses a diosmin tablet and a preparation process thereof. The tablet is formed by directly compressing a drug-containing mixture and other pharmaceutically acceptable auxiliary materials. The drug-containing mixture contains diosmin Osmin, Diethylene Glycol Monoethyl Ether and Antisticking Agent. The preparation process of the present invention is simple, the content uniformity of the preparation is good, the medicine dissolves rapidly, and it is easy for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a solid oral preparation, in particular to a tablet containing diosmin and a preparation process thereof. Background technique [0002] Diosmin is a flavonoid that was isolated from Scrophularia no do sa and was first used as a therapeutic drug in 1962. The active ingredient of diosmin tablets is micronized and purified diosmin, which has been widely used clinically in dozens of countries around the world as a vascular protective agent and a drug for treating chronic venous diseases. Diosmin has a specific affinity for veins and can improve venous tone and lymphatic drainage, mainly by protecting microcirculation from inflammatory damage and reducing capillary permeability. It has a good effect in treating acute and chronic hemorrhoids, and can significantly reduce bleeding after hemorrhoidectomy. It has good clinical tolerance, and its safety for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/7048A61K47/08A61P9/14
Inventor 苟银鹏沈海峰
Owner NANJING CHIA TAI TIANQING PHARMA
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