Carnauba wax-containing valnemulin injection

A technology of vernimulin and vernimulin hydrochloride, which is applied to the medical preparations of non-active ingredients, non-active ingredients of oil/fat/wax, drug delivery, etc.

Active Publication Date: 2015-09-16
北京中农华威科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commercially available preparations containing warnemulin hydrochloride are only coated (embedded) oral solid preparations, and there are no warnemulin hydrochloride injections, warnemulin base and their preparations on the market

Method used

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  • Carnauba wax-containing valnemulin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, preparation contains the warnemulin hydrochloride injection of Brazilian wax

[0018] Take 15g of warnemulin hydrochloride, use 20ml of 1,2-propanediol and 6ml of ethanol, stir and dissolve at room temperature to obtain a viscous solution of warnemulin hydrochloride; take 0.66g of Brazilian wax powder and 27ml of glycerol triacetate and Mix 18ml of benzyl benzoate, dissolve at 90-95°C, and lower the temperature of the material to room temperature under stirring to obtain a liquid containing Brazilian wax; mix the liquid containing Brazilian wax with the solution of vonemulin hydrochloride, and add 0.02g TBHQ, processed with a high-shear homogenizer for 10-20 minutes, to obtain vonemulin hydrochloride injection containing Brazilian wax.

Embodiment 2

[0019] Embodiment 2, preparation contains the wanimulin hydrochloride injection of carnauba wax and glycerol monooleate

[0020] Take 15g of warnemulin hydrochloride, use 20ml of 1,2-propylene glycol and 6ml of ethanol, stir and dissolve at room temperature to obtain a viscous solution of warnemulin hydrochloride; take 0.66g of Brazilian wax powder and 27ml of glycerol triacetate and Mix 18ml of benzyl benzoate, dissolve at 90-95°C, and lower the temperature of the material to room temperature under stirring to obtain a liquid containing Brazilian wax; mix the liquid containing Brazilian wax with the solution of vonemulin hydrochloride, and add 0.02g TBHQ and 10ml of glyceryl monooleate were processed with a high shear homogenizer for 10-20 minutes to obtain a vonemulin hydrochloride injection containing Brazilian wax and glyceryl monooleate.

Embodiment 3

[0021] Embodiment 3, preparation contains the injection of warnemulin citrate and warnemulin base

[0022] Take 15g of warnemulin hydrochloride, use 20ml of 1,2-propylene glycol and 6ml of ethanol, stir and dissolve at room temperature to obtain a viscous solution of warnemulin hydrochloride; take 0.66g of Brazilian wax powder and 27ml of glycerol triacetate and Mix 18ml of benzyl benzoate, dissolve at 90-95°C, lower the temperature of the material to room temperature under stirring, and obtain a liquid containing Brazilian wax; mix the viscous solution of vornimulin hydrochloride with 2.56 g of sodium citrate 2 water After grinding for 70-90 minutes, add the liquid containing Brazilian wax, 10ml glycerol monooleate, 0.02g TBHQ, and process it with a high-shear homogenizer for 10-20 minutes to obtain a mixture containing vornimulin citrate and voxelene Nimulin injection. The results of the analysis showed that the added sodium citrate reacted with warnemulin hydrochloride to ...

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PUM

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Abstract

The invention relates to a carnauba wax-containing valnemulin injection with latex-like appearance. Each liter of the injection comprises 150-180g of valnemulin hydrochloride, 2.5-11g of carnauba wax, and the balance of glyceryl triacetate / benzyl benzoate / 1,2-propylene glycol / ethanol with a volume ratio of 4.5:3:3.3:1. Each of the injection also comprises 100-150ml of glyceryl monooleate. In the preparation process of 1L of the injection, 13.0-31.2g of sodium citrate dihydrate (C6H5Na3O7.2H2O) or 19.0-31.9g of sodium carbonate decahydrate (Na2CO3.10H2O) is added. Added sodium citrate or sodium carbonate reacts with valnemulin hydrochloride. Each liter of the injection prepared in the invention includes 150-180g of valnemulin alkali and valnemulin acid salt (hydrochloride or citrate), 2.5-11g of carnauba wax, 100-150ml of glyceryl monooleate, and the balance of glyceryl triacetate / benzyl benzoate / 1,2-propylene glycol / ethanol with a volume ratio of 4.5:3:3.3:1.

Description

technical field [0001] The invention belongs to the preparation technology of veterinary drug preparations, and relates to the preparation of warnemulin hydrochloride or the acid salt of warnemulin and Veterinary long-acting injection of warnimulin. Background technique [0002] Warnemulin hydrochloride is the hydrochloride salt of warnemulin base. It is a semi-synthetic antibacterial drug specially used for animals. It has the characteristics of broad antibacterial spectrum, high activity, low toxicity and side effects, not easy to produce drug resistance, and low residue. It is mainly used in It is used to prevent mycoplasma disease and Gram-positive bacteria infection in pigs, cattle, sheep and poultry. Currently, the commercially available preparations containing warnemulin hydrochloride are only coated (embedded) oral solid preparations, and there are no warnemulin hydrochloride injections, warnemulin bases and preparations thereof on the market. [0003] Regarding in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K47/14A61K47/10A61K31/22A61K9/08A61P31/04
Inventor 王玉万戴晓曦李蕾任雅楠李莹翁志飞沈力
Owner 北京中农华威科技集团有限公司
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