Preparation method of 1,10-decanediol

Abstract

The invention discloses a preparation method of 1,10-decanediol, which is characterized by comprising the following steps: adding sebacic acid, decanediol and a titanate catalyst into a dry wax esterification reaction kettle, slowly heating to 130-180 DEG C while stirring, and carrying out vacuum dehydration reaction for 5-30 hours to obtain decanediol sebacate wax ester; and under the action of a hydrogenation catalyst, carrying out reduction reaction on the decanediol sebacate wax ester and hydrogen while keeping the hydrogen pressure at 10.0-20.0 MPa and the hydrogen flow rate at 300-1000 m<3> / hour to generate a crude decanediol product, and carrying out high-vacuum distillation to obtain the 1,10-decanediol. The sebacic acid used as the main raw material is subjected to wax esterification reaction and hydrogenation reduction reaction to finally prepare the finished product. The finished product has the advantages of high purity and high yield (up to 95% above). The method has the advantages of simple production technique, low production cost and low pollution.

Description

technical field [0001] The invention relates to the technical field of medicine and chemical industry, in particular to a preparation method of 1,10-decanediol. Background technique [0002] 1,10-Decanediol is an important fine chemical, not only used as a pharmaceutical intermediate, but also used in the production of diiododecane to prepare antibacterial and antifungal drugs (bis) clotendine and octenidine, etc. Medicine can also be used to prepare functional materials, adhesives, polymer materials, etc. Because of its low phase transition temperature and wide phase transition temperature range, it can adapt to the application of various systems with different requirements for phase transition temperature. So versatile. [0003] At present, there are three main methods for the synthesis of 1,10-decanediol: [0004] (1) The metal sodium reduction method uses a large amount of absolute ethanol in production, and is difficult to recycle, resulting in a large amount of waste...

AI Technical Summary

Problems solved by technology

[0004] (1) The metal sodium reduction method uses a large amount of absolute ethanol in production, and is difficult to recycle, resulting in a large amount of waste water and serious pollution;

[0005] (2) Organic highly active reducing agent reduction method, using sebacoyl chloride or diethyl sebacate as raw material, and preparing by reduction with potassium borohydride (sodium), lithium aluminum hydride, etc., the method has high cost and difficult storage and transportation of raw materials. Limited to small batch production in the laboratory;

[0006] (3) Catalytic hydrogenation method, using dimethyl sebacate (diethyl ester) as raw material, under the action of copper chromium catalyst, high temperature, high pressure hydrogenation reaction to prepare decanediol, this method requires high equipment and investment Large, the catalyst contains chromium, which is easy to cause environmental pollution

[0007] The production process of the prior art is complicated, the production cost is high, the pollution is large, and its finished product yield is low

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