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Riboflavin-containing solid preparation and preparation method thereof

A technology of solid preparations and riboflavin, which is applied in the direction of medical preparations containing active ingredients, organic chemical methods, and pharmaceutical formulas, can solve the problems of increased difficulty in sewage treatment, increased sewage treatment volume, and many operating steps, and achieves an improvement The effect of product value, reduction of treatment difficulty and sewage volume, and high extraction yield

Active Publication Date: 2015-10-07
HUBEI GUANGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, this method has following shortcoming: one, in order to obtain the riboflavin that content is at least 98%, need to carry out centrifugation 3 times, before each centrifugation, the solid discharge obtained after the previous centrifugation will be suspended with production water, like this There are many operation steps, the process is complicated, and a large amount of waste water is generated, which increases the difficulty of subsequent sewage treatment
A large amount of acid is used during crystallization, and the crystallization temperature is high. In order to completely precipitate riboflavin, the amount of deionized water is large, which increases the amount of subsequent sewage treatment and brings inconvenience to production.

Method used

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  • Riboflavin-containing solid preparation and preparation method thereof
  • Riboflavin-containing solid preparation and preparation method thereof
  • Riboflavin-containing solid preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of riboflavin crystal of the present invention

[0037] (1), preparation method

[0038] The 3000L riboflavin fermented liquid is subjected to a centrifugation solid-liquid separation, and the centrifugal RCF (relative centrifugal force) of the centrifuge is about 3000xg to obtain a concentrated 30-40L riboflavin heavy phase. Use a screw pump to pump this riboflavin heavy phase into a plate and frame filter for filtration, and wash the riboflavin filter cake with 2000L deionized water to obtain 100kg of wet riboflavin crude product with 65.5% moisture content and 77% riboflavin purity . Add 120L of 36% hydrochloric acid solution in a 3t reaction tank, and add 100kg of wet riboflavin crude product to the hydrochloric acid solution and heat it to 70°C. After the riboflavin is completely dissolved, take a sample solution from the reaction tank to confirm the riboflavin To dissolve the riboflavin, add 5kg of activated carbon to the solution a...

Embodiment 2

[0044] Embodiment 2: the preparation of riboflavin crystal of the present invention

[0045] (1), preparation method

[0046] 5000L riboflavin fermented liquid is subjected to a centrifuge solid-liquid separation, and the centrifugal RCF (relative centrifugal force) of the centrifuge is about 3200xg to obtain concentrated 50-60L riboflavin heavy phase. Use a screw pump to pump this riboflavin heavy phase into a plate and frame filter for filtration, and wash the riboflavin filter cake with about 2000L of deionized water to obtain about 150kg of wet riboflavin with a moisture content of 63.9% and a purity of 79% riboflavin Vegetarian crude products. Add about 180L of 35.0% hydrochloric acid into the 3t reaction tank, and add 150kg of wet riboflavin crude product to the hydrochloric acid solution and heat it to 65°C. After the riboflavin is completely dissolved, take a sample solution from the reaction tank to confirm the riboflavin To dissolve the riboflavin, add 10kg of acti...

Embodiment 3

[0053] Embodiment 3: the capsule containing riboflavin of the present invention

[0054] Bulk drug: 48% by weight of riboflavin obtained in Example 1, 44.5% by weight of microcrystalline cellulose, 1.5% by weight of croscarmellose sodium, 2.0% by weight of 40% ethanol aqueous solution, 1.0% by weight of micropowder silica gel and argentine Spartame 3.0%.

[0055] Preparation method: pass microcrystalline cellulose, croscarmellose sodium and aspartame through an 80-mesh sieve, add riboflavin and mix evenly, add 40% ethanol aqueous solution to the evenly mixed powder, knead the soft material, Pass through a 20-mesh sieve to granulate, dry, pass through a 40-mesh sieve for granulation, add micropowder silica gel and fill it into capsules.

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Abstract

The invention relates to a riboflavin-containing solid preparation. The riboflavin-containing solid preparation comprises, by weight, 23.0-65.0% of riboflavin, 18.0-65.0% of a diluent, 0.25-7.5% of a disintegrating agent, 0.1-5.5% of a binder and 0.5-2.0% of a lubricant. The riboflavin comprises spherical crystals with sizes of 25-35 micrometers and has purity greater than 98%. The riboflavin has the advantages of high purity, good processing performances and good fluidity. The solid preparation has a fast disintegrating rate and good stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a riboflavin-containing solid preparation and a preparation method thereof. Background technique [0002] riboflavin aka vitamin B 2 (referred to as "VB 2 ”), is an isoalloxazine derivative containing a ribitol group. VB 2 It is widely used as a basic nutrient, and is widely used in feed and food industries, second only to vitamins A and D, and products with a content of 80% can be used as feed. It is also sometimes used as a colorant in the food, feed and pharmaceutical industries. It is an essential water-soluble vitamin for the human body. Riboflavin has a wide range of physiological functions and can be synthesized in microorganisms and higher plants, while animals and humans cannot, and must be ingested from food, so it is listed by the World Health Organization (WHO) as the sixth element for evaluating human growth and nutritional status. It is one of the maj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D475/14A61K31/525
CPCA61K31/525C07B2200/13C07D475/14
Inventor 郭韶智陈志远伍文俊廖新建王筱梅
Owner HUBEI GUANGJI PHARMA
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