A kind of separation and purification method of dalbavancin

A technology for separation and purification of dalbavancin, applied in peptide preparation methods, chemical instruments and methods, organic chemistry, etc., to achieve the effect of no pollution cost and short purification cycle
CN105001309BActive Publication Date: 2018-09-25CHANGSHU NANOMICRO BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGSHU NANOMICRO BIOTECHNOLOGY CO LTD
Publication Date
2018-09-25

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Abstract

The invention provides a separation and purification method for dalbavancin. The method comprises the following steps: dissolving and filtering a crude dalbavancin extract; loading a sample of a crude solution obtained after filtering into a chromatographic column equipped with polystyrene high-molecular polymer microspheres for chromatography; carrying out gradient elution on a target product with an aqueous phosphoric acid solution and an organic solvent as mobile phases; and collecting solutions with a target peak value in sections and combining constituent solutions meeting requirements. The separation and purification method is simple, can realize large-scale production and has a high and stable recovery rate.
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Description

technical field

[0001] The invention relates to the field of medicine purification, in particular to a method for efficiently separating and purifying dalbavancin. Background technique

[0002] Dalbavancin (Dalbavancin) is a new type of semi-synthetic glycopeptide antibiotics. Its mechanism of action is the same as that of vancomycin and teicoplanin. It can be widely used as a drug for the treatment of skin and soft tissue infections by inhibiting the biosynthesis of the cell wall of G+ bacteria. drug. Dalbavancin has unique pharmacokinetic properties, long half-life, can be administered at weekly intervals, and can be completely metabolized. At present, dalbavancin has achieved good results in the treatment of catheter-related blood-borne infections and skin and soft tissue infections. It has excellent antibacterial activity and safety in vivo, and is an ideal second-generation glycopeptide antibiotic.

[0003] Dalbavancin consists of structurally similar A 0 、A 1 , B ...

Claims

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