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PH-responsive sodium alginate nano gel and production method thereof

A technology of sodium alginate and nanogel, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, aerosol delivery, etc. It can solve the problems of poor quality reliability, low output, high cost, etc., and reach the size of the gel Controllable, simple preparation process, and good application prospects

Inactive Publication Date: 2015-11-04
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these chemicals are difficult to remove before final use, thus affecting health
Moreover, this multi-step preparation strategy often causes problems such as environmental load, high cost, low yield, and poor quality reliability.

Method used

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  • PH-responsive sodium alginate nano gel and production method thereof
  • PH-responsive sodium alginate nano gel and production method thereof
  • PH-responsive sodium alginate nano gel and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In a three-neck flask, add 0.2mL 5mg / mL sodium alginate aqueous solution, dilute it with ultrapure water, and stir for 0.5h; then, under ultrasonic conditions, slowly add 0.225mL 0.01mol / L calcium chloride solution dropwise solution, dilute to a final volume of 20.0 mL with ultrapure water, and stir for 2 h. The obtained crude product solution was dialyzed four times in ultrapure water, and the molecular weight cut-off of the dialysis bag used was 10KDa to obtain an aqueous solution of nanogel, which was freeze-dried to obtain flocculent sodium alginate nanogel.

[0029] The average particle size and potential of the obtained nanogels are as figure 1 As shown, they are 350-375nm and -31.2mV respectively.

Embodiment 2

[0031] In a three-neck flask, add 0.2mL 5mg / mL sodium alginate aqueous solution, dilute it with ultrapure water, and stir for 0.5h; then, under ultrasonic conditions, slowly add 0.225mL 0.01mol / L calcium chloride solution dropwise solution, dilute to a final volume of 13.3 mL with ultrapure water, and stir for 2 h. The obtained crude product solution was dialyzed four times in ultrapure water, and the molecular weight cut-off of the dialysis bag used was 10KDa to obtain an aqueous solution of nanogel, which was freeze-dried to obtain flocculent sodium alginate nanogel.

[0032] The average particle size and potential of the obtained nanogels are as figure 1 As shown, they are 300-355nm and -34.2mV respectively.

Embodiment 3

[0034] In the three-neck flask, add 0.4mL 5mg / mL sodium alginate aqueous solution, dilute it with ultrapure water, and stir for 0.5h; then, under ultrasonic conditions, slowly add 0.45mL 0.01mol / L calcium chloride solution dropwise solution, dilute to a final volume of 20.0 mL with ultrapure water, and stir for 2 h. The obtained crude product solution was dialyzed four times in ultrapure water, and the molecular weight cut-off of the dialysis bag used was 10KDa to obtain an aqueous solution of nanogel, which was freeze-dried to obtain flocculent sodium alginate nanogel.

[0035] The average particle size and potential of the obtained nanogels are as figure 1 As shown, they are 170-210nm and -37.2mV respectively.

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Abstract

The invention discloses pH-responsive sodium alginate nano gel and a production method thereof. The method includes the steps of firstly, dissolving and mixing sodium alginate and antitumor drugs; secondly, under an ultrasonic condition, allowing mixed liquid to react with crosslinking agent solution and determining volume; thirdly, performing dialysis purification and freeze drying to obtain flocculent sodium alginate nano gel products. The method has the advantages that the method is simple in process, safe to operate and mild in reaction conditions, and the gel with negative charge on the surface and with the particle size range of 170-700 nanometers can be obtained by controlling reactant concentration; the gel of the particle size of 170-220 nanometers is of a regular spherical structure, can carry various hydrophilic antitumor drugs, has an evident drug release controlling effect, can effectively inhibit tumor growth, and has potential for being applied to the field of cancer treatment and promising market prospect.

Description

technical field [0001] The invention relates to a pH-responsive sodium alginate nanogel and a preparation method thereof, belonging to the technical field of nanomaterials and their preparation. Background technique [0002] Nanogel refers to a three-dimensional network structure formed by chemical or physical cross-linking of polymers with nanoscale (10-1000 nm) size. As a drug carrier, nanogel can significantly improve the bioavailability of drugs and the delivery and release performance of drugs in vivo. It is a kind of safe system with potential biomedical application value. [0003] In the past decade, multiple stimuli-responsive drug delivery systems have been rapidly developed in the research of cancer diagnosis and therapy. It is well known that the pH value of the tumor extracellular environment (pH ~ 6.5) is lower than that of blood (pH ~ 7.4), and the pH value of endosomes and lysosomes (pH 5.0 ~ 5.5) is lower. Therefore, the design of pH-responsive nanogels, su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/06C08J3/075C08J3/24C08L5/04C08K3/16C08K3/26
Inventor 喻发全薛亚楠夏晓洋喻波龙思会
Owner WUHAN INSTITUTE OF TECHNOLOGY
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