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Preparation method of choline alfoscerate crystal

A technology of choline alfoscerate and crystal, which is applied in the field of preparation of choline alfoscerate, can solve the problems such as the decrease of the purity of choline alfoscerate, weakening of the health-care performance and medicinal value of choline alfoscerate

Active Publication Date: 2017-09-01
WUHU FOMAN BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the prior art, the commercially available choline alfoscerate is mainly extracted from the by-product of soybean with ethanol for a single time. The choline alfoscerate obtained by this method is easy to absorb the moisture in the air when placed in the air, and the water absorption rate If it is too high, the purity of choline alfoscerate will be severely reduced, which will greatly weaken the health care performance and medicinal value of choline alfoscerate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] The invention provides a kind of preparation method of choline alfoscerate crystal, and this preparation method comprises:

[0016] (1) mixing choline alfoscerate and alcohol to prepare mixture M1;

[0017] (2) Mix the mixture M1 and sulfate, perform the first filtration after cooling and take the filtrate to obtain the mixture M2;

[0018] (3) carrying out the first concentration of the mixture M2 to obtain the mixture M3;

[0019] (4) mixing the mixture M3 with an organic solvent and performing a second concentration to obtain a mixture M4;

[0020] (5) crystallize after mixing ethyl acetate and the mixture M4 and perform second filtration to obtain crystal M5;

[0021] (6) post-processing the crystal M5 to obtain choline alfoscerate crystals.

[0022] In the present invention, the specific type of alcohol can be selected in a wide range, and can be selected from one or more of ethanol, methanol and ethylene glycol. In order to fully dissolve choline alfoscerate, p...

Embodiment 1

[0039] (1) Mix and stir choline alfoscerate and ethanol (100:500 by weight) at 38°C for 60 minutes to prepare mixture M1;

[0040] (2) Mix the mixture M1 and sodium sulfate (100:35 by weight), cool at 27°C for 60 minutes, then perform the first filtration and take the filtrate to obtain the mixture M2;

[0041] (3) Under the conditions of 48°C and 70KPa, the mixture M2 was first concentrated for 1.5h to obtain the mixture M3;

[0042] (4) Mix the mixture M3 and ethanol (100:60 by weight) and conduct the second concentration at 35° C. for 2 h to prepare the mixture M4;

[0043] (5) At 48°C, mix ethyl acetate and the mixture M4 (50:100 by weight) under the condition of 70KPa, crystallize after mixing, and perform second filtration to obtain crystal M5;

[0044] (6) Drying the crystal M5 at 0.7 MPa for 2 hours at 40° C. to obtain choline alfoscerate crystal A1.

Embodiment 2

[0046] (1) At 37°C, mix and stir choline alfoscerate and methanol (100:450 by weight) for 80 minutes to prepare mixture M1;

[0047] (2) Mix the mixture M1 and potassium sulfate (weight ratio: 100:30), cool at 25°C for 50 minutes, then perform the first filtration and take the filtrate to obtain the mixture M2;

[0048] (3) At 45°C and 80KPa, the mixture M2 was first concentrated for 1 hour to obtain the mixture M3;

[0049] (4) Mix the mixture M3 and acetone (100:50 by weight) and conduct the second concentration at 40° C. for 1 h to prepare the mixture M4;

[0050] (5) At 45°C, mix ethyl acetate and the mixture M4 (40:100 by weight) under the condition of 60KPa, crystallize and perform second filtration to obtain crystal M5;

[0051] (6) Drying the crystal M5 at 0.6 MPa for 1 h at 38° C. to obtain choline alfoscerate crystal A2.

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Abstract

The invention discloses a preparation method of choline alfoscerate crystal. The preparation method comprises: (1) mixing choline alfoscerate and alcohol to prepare a mixture M1; (2) mixing the mixture M1 and sulfate, cooling Then perform the first filtration and take the filtrate to obtain the mixture M2; (3) carry out the first concentration of the mixture M2 to obtain the mixture M3; (4) mix the mixture M3 and the organic solvent and perform the second concentration to obtain the mixture M4 (5) mixing ethyl acetate and the mixture M4 and then crystallizing and performing second filtration to obtain crystals M5; (6) post-processing the crystals M5 to obtain choline alfoscerate crystals. The choline alfoscerate crystal prepared by the method has low water absorption rate in the air, high purity, and high health care performance and medicinal value.

Description

technical field [0001] The invention relates to the field of preparation of choline alfoscerate, in particular to a preparation method of choline alfoscerate crystal. Background technique [0002] Choline alfoscerate is a water-soluble substance obtained by removing two fatty acids from PC (phosphatidylcholine), the main phospholipid constituting the cell membrane. Choline alfoscerate exists widely in living organisms, mainly in emulsions and body fluids. Choline alfoscerate can improve the cognitive ability of the brain, has an excellent preventive effect on Alzheimer's disease, and can even repair the partially damaged cognitive ability of early senile dementia patients. It can also effectively protect liver tissue from Infiltrated by fatty acids produced by toxic carbon tetrachloride and high-fat protein foods, it has the effects of anti-hyperlipidemia and blood vessel protection. In addition, choline alfoscerate can also promote the growth of adolescents and improve the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/09
Inventor 苏福男
Owner WUHU FOMAN BIOPHARMA CO LTD