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Polymer coating microneedle patch convenient for antibiotic skin testing and preparation method thereof

A technology of polymer coating and microneedle sticking, which is applied in the fields of drug devices, ovulation diagnosis, and other medical devices. It can solve problems such as difficulty in popularization, high sensitivity, and undetectable allergic reactions, and achieve convenient drug delivery. , the effect of rapid skin test

Inactive Publication Date: 2015-12-09
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all three forms have their limitations and flaws
The sensitivity of the intradermal test is higher than that of other skin tests, which increases the probability of severe adverse reactions on the skin; and the severity and length of the scratches in the prick test are difficult to grasp, so it is difficult to promote; the sensitivity of the patch test is not high enough. Allergic reactions are difficult to detect

Method used

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  • Polymer coating microneedle patch convenient for antibiotic skin testing and preparation method thereof
  • Polymer coating microneedle patch convenient for antibiotic skin testing and preparation method thereof
  • Polymer coating microneedle patch convenient for antibiotic skin testing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Mix the polydimethylsiloxane and the curing agent according to the mass ratio of 10:1, stir well and remove the bubbles in it by vacuuming; then put the liquid polydimethylsiloxane containing the curing agent to Pour it into a container placed horizontally, place it in an oven at 60° C. and heat it for 5-10 hours to obtain solid polydimethylsiloxane. Then take it out of the container, and use laser cutting, micro-nano processing technology to prepare micro-needle molds, such as figure 1 shown.

[0018] 2. Place the polylactic acid particles on the microneedle mold, heat and melt the polylactic acid particles at a high temperature of 200°C to make them all melt, and finally mold them while they are hot, and obtain polymer solid microneedles after cooling to room temperature. needle patch. The sulforhodamine B (sulforhodamine B) and polyvinyl alcohol, sucrose, and deionized water were prepared into a high-concentration solution according to the mass ratio of 0.015:4:...

Embodiment 2

[0021] 1. Mix polydimethylsiloxane and curing agent according to the mass ratio of 10:1, stir well and vacuumize to remove the air bubbles; then put the liquid polydimethylsiloxane containing curing agent to Pouring in a horizontally placed container, heating in an oven at 60°C for 5-10 hours to obtain solid polydimethylsiloxane, and then taking it out of the container, and using laser cutting, micro-nano processing technology to prepare microneedle molds.

[0022] 2. Place the polylactic acid (PLA) particles on the microneedle mold, heat and melt the polylactic acid particles at a high temperature of 200 ° C to make them all melt, and finally mold them while they are hot, and obtain a high-quality product after cooling to room temperature. Molecular solid microneedle patch.

[0023] 3. Mix sulforhodamine B (sulforhodamine B) with polyvinyl alcohol (PVA), trehalose, and deionized water according to the mass ratio of 0.005:4:6:10, 0.01:4:6:10, and 0.015:4:6, respectively :10,...

Embodiment 3

[0027] 1. Mix the polydimethylsiloxane and the curing agent according to the mass ratio of 10:1, stir well and remove the bubbles in it by vacuuming; then put the liquid polydimethylsiloxane containing the curing agent to Pouring in a horizontally placed container, heating in an oven at 60°C for 5-10 hours to obtain solid polydimethylsiloxane, and then taking it out of the container, and using laser cutting, micro-nano processing technology to prepare microneedle molds.

[0028] 2. Place the polylactic acid (PLA) particles on the microneedle mold, heat and melt the polylactic acid particles at a high temperature of 200 ° C to make them all melt, and finally mold them while they are hot, and obtain a high-quality product after cooling to room temperature. Molecular solid microneedle patch.

[0029] 3. Prepare penicillin, polyvinyl alcohol (PVA), glucose, and deionized water at a mass ratio of 0.015:4:6:10 to make a high-concentration solution.

[0030] 4. Dip the needle body ...

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Abstract

The invention belongs to the technical field of administration equipment, and particularly relates to a polymer coating microneedle patch convenient for antibiotic skin testing and a preparation method thereof. A microneedle in the polymer coating microneedle patch comprises a needle portion and a coating portion, the needle portion is made from a biodegradable and insoluble polymer material, and the coating portion comprises a soluable polymer material, a stabilizer and drug which is antibiotic. Compared with the prior art, the polymer coating microneedle patch has the advantages that the polymer coating microneedle patch can achieve the objective of quick skin testing, and an administration mode through the polymer coating microneedle is noninvasive, so that no damage is caused to human bodies. In addition, the administration mode is convenient and saving and does not bring about biological waste.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to a polymer-coated microneedle patch convenient for antibiotic skin testing and a preparation method thereof. Background technique [0002] Antibiotics are a class of secondary metabolites with anti-pathogen or other activities produced by microorganisms (including bacteria, fungi, actinomycetes) or higher animals and plants in the course of life, which can interfere with the developmental functions of other living cells chemicals. Antibiotics commonly used in clinical practice include extracts from the culture fluid of genetically modified engineered bacteria and chemically synthesized or semi-synthesized compounds. There are no less than 10,000 known natural antibiotics. Typically, a skin test is required before antibiotics are given. Currently, there are three types of skin tests: intradermal test, prick test and patch test. However, all three for...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61B10/00A61L31/16A61L31/14A61L31/06A61L31/04
Inventor 郭新东陈洋
Owner BEIJING UNIV OF CHEM TECH
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