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A kind of chitosan coated vitamin C microcapsule and preparation method thereof

A vitamin and chitosan technology, applied in the chemical industry, can solve problems such as poor stability and low coating rate of vitamin C microcapsules, and achieve good application prospects, good biocompatibility and degradability, and prevent oxidation Effect

Active Publication Date: 2017-05-31
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For the above-mentioned technical problems in the prior art, the invention provides a kind of chitosan-coated vitamin C microcapsules and preparation method thereof, described this chitosan-coated vitamin C microcapsules and preparation method thereof have solved The vitamin C microcapsules coating rate in the prior art is not high, the technical problem of poor stability

Method used

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  • A kind of chitosan coated vitamin C microcapsule and preparation method thereof

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Effect test

Embodiment 1

[0028] A chitosan-coated vitamin C microcapsule, the parts by weight of each raw material are as follows:

[0029] Vitamin C 0.4 parts

[0030] Anhydrous magnesium sulfate 0.02 parts

[0031] 15.5 parts of soybean oil

[0032] Span 80 0.4 parts

[0033] Glacial acetic acid 0.6 parts

[0034] Chitosan 0.6 parts

[0035] Tween 80 1.6 parts

[0036] Sodium tripolyphosphate 0.4 parts

[0037] The balance is deionized water.

[0038] The preparation method of above-mentioned chitosan-coated vitamin C microcapsules comprises the following steps:

[0039] 1) Dissolve 0.4 parts of vitamin C in 3.16 parts of deionized water, add 0.02 parts of anhydrous magnesium sulfate, and sonicate until vitamin C is completely dissolved in water before use.

[0040] 2) Put the vitamin C aqueous solution obtained in step (1), 15.5 parts of soybean oil and 0.4 parts of Span 80 in a 100 mL three-necked flask, mechanically stir at 300 r / min for 1 hour, and homogenize for 4 minutes to obtain an i...

Embodiment 2

[0046] A chitosan-coated vitamin C microcapsule, the parts by weight of each raw material are as follows:

[0047] Vitamin C 2.5 parts

[0048] Anhydrous magnesium sulfate 0.04 parts

[0049] 27.0 parts of soybean oil

[0050] Span 80 0.6 parts

[0051] Glacial acetic acid 1.2 parts

[0052] Chitosan 1.0 parts

[0053] Tween 80 2.9 parts

[0054] Sodium alginate 0.6 parts

[0055] The balance is deionized water.

[0056] The preparation method of above-mentioned chitosan-coated vitamin C microcapsules comprises the following steps:

[0057] 1) Dissolve 2.5 parts of vitamin C in 10.88 parts of deionized water, add 0.04 parts of anhydrous magnesium sulfate, and sonicate until the vitamin C is completely dissolved in water before use.

[0058] 2) Put the vitamin C aqueous solution obtained in step (1), 27.0 parts of soybean oil and 0.6 part of Span 80 in a 100 mL three-necked flask, mechanically stir at 500 r / min for 2 hours, and homogenize for 6 minutes to obtain an inte...

Embodiment 3

[0064] A chitosan-coated vitamin C microcapsule, the parts by weight of each raw material are as follows:

[0065] Vitamin C 0.7 parts

[0066] Anhydrous magnesium sulfate 0.03 parts

[0067] 22.0 parts of soybean oil

[0068] Span 80 0.5 parts

[0069] Glacial acetic acid 0.8 parts

[0070] Chitosan 0.8 parts

[0071] Tween 80 1.8 parts

[0072] Calcium chloride 0.5 parts

[0073] The balance is deionized water.

[0074] The preparation method of above-mentioned chitosan-coated vitamin C microcapsules comprises the following steps:

[0075] 1) Dissolve 0.7 parts of vitamin C in 10.32 parts of deionized water, add 0.03 parts of anhydrous magnesium sulfate, and sonicate until the vitamin C is completely dissolved in water before use.

[0076] 2) Put the vitamin C aqueous solution obtained in step (1), 22.0 parts of soybean oil and 0.5 part of Span 80 into a 100 mL three-necked flask, mechanically stir at 400 r / min for 1.5 h, and homogenize for 5 minutes to obtain an inter...

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Abstract

The invention discloses a chitosan-coated vitamin C micro-capsule. The chitosan-coated vitamin C micro-capsule is prepared from, by mass, 0.4-2.5 parts of vitamin C, 0.02-0.04 part of anhydrous magnesium sulfate, 15.5-27.0 parts of soybean oil, 0.4-0.6 part of Span 80, 0.6-1.2 parts of glacial acetic acid, 0.6-1.0 part of chitosan, 1.6-2.9 parts of polysorbate 80, 0.4-0.6 part of curing agents and the balance deionized water. The invention further provides a preparing method for the chitosan-coated vitamin C micro-capsule. The chitosan-coated vitamin C micro-capsule prepared by adopting a multiphase emulsion method is of a regular spherical multi-core structure, and the coverage rate of vitamin C can be 20-50%. The prepared vitamin C micro-capsule effectively prevents the vitamin C from being oxidized, and has good biocompatibility and degradability.

Description

technical field [0001] The invention belongs to the field of chemical industry and relates to a vitamin C microcapsule, in particular to a chitosan-coated vitamin C microcapsule and a preparation method thereof. Background technique [0002] As a natural antioxidant, vitamin C is widely used in medicine, food, cosmetics and many other fields. However, vitamin C will be decomposed and deteriorated by environmental influences such as high temperature, pH, moisture, light and air, which limits the effect and application range of vitamin C. Encapsulation of vitamin C by using microcapsule technology can not only improve the stability of vitamin C to the environment, but also enable the slow release of vitamin C. At present, the main preparation methods of vitamin C capsules include spray drying method, sugar vitrification technology, oil phase phase separation method, interfacial polymerization method, water bath drying method and yeast microencapsulation method. The multiple-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02
Inventor 胡静邓维钧田婷范逸君
Owner SHANGHAI INST OF TECH
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