Application of hyperin to treatment of ulcerative colitis

A technology for ulcerative colitis and hyperin, which is applied in the field of medicine, can solve the problems of many side effects, poor curative effect, and difficult long-term application.

Inactive Publication Date: 2015-12-16
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The treatment of UC has been limited to aminosalicylate preparations, systemic and local application of glucocorticoid preparations and immunosuppressants, but the efficacy is not good and side effects are many
Biotherapeutic drugs (anti-tumor necrosis factor antibodies, interferon) under research often produce anti-drug antibodies during treatment, making long-term application difficult

Method used

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  • Application of hyperin to treatment of ulcerative colitis
  • Application of hyperin to treatment of ulcerative colitis
  • Application of hyperin to treatment of ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Hyperoside Anti-ulcerative Colitis Activity Test

[0021] 1. Materials

[0022] 1.1 Animals Wistar rats, weighing 180-200 g, half male and half male, were purchased from the Experimental Animal Research Center of Third Military Medical University.

[0023] 1.2 The drug hyperoside (Hyp) was purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd.

[0024] 1.3 Reagent 2,4,6-Trinitrobenzenesulfonic acid solution (2,4,6-Trinitrobenzenesulfonic acid solution, TNBS) aqueous solution was purchased from Sigma Company (5% (w / v); myeloperoxidase (MPO), propane Aldehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) and Coomassie Leucine blue protein kits were purchased from Nanjing Jiancheng Bioengineering Institute; heme oxidase-1 (HO-1) antibody Purchased from CST Corporation.

[0025] 2. Method

[0026] 2.1 Grouping Rats were randomly divided into 5 groups according to body weight, 6 in each group, respectively normal control group (NS), model cont...

Embodiment 2

[0051] The preparation of embodiment 2 hyperoside tablets

[0052] Hyperin 200g, add starch 200g, microcrystalline cellulose 60g, magnesium stearate 2g, mix evenly, granulate, dry, sieve and compress into tablets (1000 pieces), to obtain hyperin tablets .

Embodiment 3

[0053] The preparation of embodiment 3 hyperin capsules

[0054] Hyperin 300g, add starch 300g, magnesium stearate 2g, mix well, granulate, dry, pack into capsules (1000) after sieving, obtain the capsule of hyperin.

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Abstract

The invention discloses application of hyperin to treatment of ulcerative colitis. Through adoption of the hyperin, the MPO activity in colonic tissues can be obviously lowered, the degree of neutrophil infiltration can be reduced, and inflammation can be relieved; the ulcer area of colonic mucosa can be obviously reduced; colonic congestion and edema as well as intestinal wall adhesion can be relieved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of hyperin in treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is one of inflammatory bowel disease (Inflammatory bowel disease, IBD), is a non-specific inflammatory bowel disease of unknown cause, the lesions are mainly located in the mucosal layer of the colon, and mainly ulcers, It mostly involves the rectum and distal colon, but can extend proximally and even throughout the entire colon. The main clinical symptoms are diarrhea, pus and blood in the stool, abdominal pain and tenesmus. Primary disease can be seen in any age, but is most common with 20-30 years old, and male is slightly more than female. [0003] The treatment of UC has been limited to aminosalicylate preparations, systemic and local application of glucocorticoid preparations and immunosuppressants, but the curative effect is not good and side effects are many. The...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/00A61P1/04
Inventor 陈剑鸿蔡永青李小丽辛海燕王显凤江山
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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