A kind of bone substitute material with bionic natural bone structure constructed by mineralized nanofibers and its preparation method
A nanofiber and bone replacement technology, applied in medical science, prosthesis, etc., can solve the problems of limited material sources, limited clinical application, inability to resemble natural biological tissues in structure, composition and function, and achieve good strength and structural simulation. , the effect of good biocompatibility and bioactivity
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Embodiment 1
[0025] (1) Put tussah silk fibroin and polylactic acid in a hexafluoroisopropanol solution at a mass ratio of 1:9, and perform magnetic stirring at room temperature for 2 days to obtain an electrospinning spinning solution with a mass fraction of 7 %;
[0026] (2) Prepare a mixed solvent with deionized water and absolute ethanol at a mass ratio of 1:4, put 32g of polyvinylpyrrolidone into the mixed solvent, and stir magnetically at room temperature for 40 minutes to obtain polyethylene with a mass fraction of 40%. pyrrolidone solution;
[0027](3) Using the mixed spinning solution in step (1) as the core layer solution, using the polyvinylpyrrolidone solution in step (2) as the shell layer solution, and using electrospinning to prepare nanofibers with a skin-core structure nanofiber yarns. The skin layer of the nanofiber is polyvinylpyrrolidone, the core layer of the nanofiber is a mixed composition of silk fibroin and polylactic acid, the electrospinning voltage is 18 kV, an...
Embodiment 2
[0033] (1) Put tussah silk fibroin and polylactic acid in a hexafluoroisopropanol solution at a mass ratio of 1:10, and magnetically stir at room temperature for 3 days to obtain an electrospinning spinning solution with a mass fraction of 6%;
[0034] (2) Prepare a mixed solvent with deionized water and absolute ethanol at a mass ratio of 1:1.25, put 17.5 g of polyvinylpyrrolidone into the mixed solvent, and magnetically stir at room temperature for 50 min to obtain a mass fraction of 35 % Polyvinylpyrrolidone solution;
[0035] (3) Using the mixed spinning solution in step (1) as the core layer solution, using the polyvinylpyrrolidone solution in step (2) as the shell layer solution, and using electrospinning to prepare nanofibers with a skin-core structure The nanofiber yarn, the skin layer of the nanofiber is polyvinylpyrrolidone, the core layer of the nanofiber is a mixed composition of silk fibroin and polylactic acid; the voltage of the electrospinning is 22 kV, and the...
Embodiment 3
[0040] (1) Put tussah silk fibroin and polylactic acid in a hexafluoroisopropanol solution at a mass ratio of 1:6, and magnetically stir at room temperature for 5 days to obtain an electrospinning spinning solution with a mass fraction of 9%;
[0041] (2) Prepare a mixed solvent with deionized water and absolute ethanol at a mass ratio of 1:2, put 17 g of polyvinylpyrrolidone into the mixed solvent, and stir magnetically at room temperature for 90 min to obtain polyvinylpyrrolidone with a mass fraction of 32 %. Vinylpyrrolidone solution;
[0042] (3) Using the mixed spinning solution in step (1) as the core layer solution, using the polyvinylpyrrolidone solution in step (2) as the shell layer solution, and using electrospinning to prepare nanofibers with a skin-core structure The nanofiber yarn, the skin layer of the nanofiber is polyvinylpyrrolidone, the core layer of the nanofiber is a mixed composition of silk fibroin and polylactic acid, the electrospinning voltage is 19 k...
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