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Preparation method of self-foaming porous composite bone repair bracket

A self-foaming and bone repair technology, applied in the fields of medical science, tissue regeneration, prosthesis, etc., can solve the problems of difficulty in mixing foaming agent water evenly, difficulty in applying composite porous scaffolds, and affecting the uniformity of pore structure of scaffolds. Simple and easy to implement, meet the requirements, and have broad application prospects

Inactive Publication Date: 2015-12-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN103495203A reports a method for preparing cellular polyurethane scaffolds containing disulfide bonds using the biological rattan template method, but this method is difficult to apply to the preparation of composite porous scaffolds using polyurethane-based composite materials containing inorganic fillers with high viscosity
Although the foaming agent water is safe and non-toxic and has no side effects, the calcium phosphate-polyurethane composite material system has a high viscosity as the reaction progresses, and it is difficult for the foaming agent water to be evenly mixed into it, thus affecting the uniformity of the pore structure of the scaffold

Method used

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  • Preparation method of self-foaming porous composite bone repair bracket
  • Preparation method of self-foaming porous composite bone repair bracket
  • Preparation method of self-foaming porous composite bone repair bracket

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Embodiment 1

[0023] According to the method reported by Li Limei et al. "Interfacial structure and mechanical properties of alcohol-modified castor oil-based polyurethane / n-HA composite scaffold material" (Journal of Inorganic Materials, 2013, 28(8):811-817), crystallize with calcium hydrogen phosphate The hydrate replaces the nano-hydroxyapatite in the literature to prepare the calcium hydrogen phosphate-polyurethane composite material prepolymer, and then adds the chain extender 1,4-butanediol and continues to react for a period of time to obtain a viscous composite material. In the calcium hydrogen phosphate-polyurethane composite material, the crystalline hydrate of calcium hydrogen phosphate is about 30wt%, corresponding to about 6wt% of bound water as a foaming agent, and the viscous calcium hydrogen phosphate-polyurethane composite material is put into the mold, Curing and foaming at 90°C for 24 hours. After curing, a self-foaming porous composite bone repair scaffold is obtained. ...

Embodiment 2

[0025] According to the method reported in the literature described in Example 1, the calcium hydrogen phosphate crystalline hydrate is used to replace the nano-hydroxyapatite in the literature to prepare the calcium hydrogen phosphate-polyurethane composite material prepolymer, and then add the chain extender 1,4- Continue to react for a period of time after butanediol to obtain a viscous composite material. In the calcium hydrogen phosphate-polyurethane composite material, the crystalline hydrate of calcium hydrogen phosphate is about 40wt%, and correspondingly contains about 8wt% bound water as a blowing agent. The viscous calcium hydrogen phosphate-polyurethane composite material was put into the mold, and aged and foamed at 110°C for 4 hours. After curing, a self-foaming porous composite bone repair scaffold is obtained.

Embodiment 3

[0027] According to the method reported in the literature described in Example 1, the calcium hydrogen phosphate crystalline hydrate is used to replace the nano-hydroxyapatite in the literature to prepare the calcium hydrogen phosphate-polyurethane composite material prepolymer, and then add the chain extender 1,4- Continue to react for a period of time after butanediol to obtain a viscous composite material. In the calcium hydrogen phosphate-polyurethane composite material, the crystalline hydrate of calcium hydrogen phosphate is about 10wt%, and correspondingly contains about 2wt% bound water as a blowing agent. The viscous calcium hydrogen phosphate-polyurethane composite material is put into the mold and aged and foamed at 100°C for 12 hours. After curing, a self-foaming porous composite bone repair scaffold is obtained.

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Abstract

The invention relates to a preparation method of a treatment material, in particular to a preparation method of a self-foaming porous composite bone repair bracket. The preparation method comprises the following steps: during the synthesis process of a phosphomycin calcium-polyurethane composite, foaming agent water is uniformly compounded in the material in a phosphomycin calcium crystal water form; crystal water is released under a certain condition to react with isocyanato in polyurethane system, so as to generate CO2 gas, achieve self-foaming formation of the composite system, and prepare a phosphomycin calcium-polyurethane composite bone repair bracket with porosity and uniform pores. The in situ self-foaming method is easy and feasible.

Description

technical field [0001] The invention relates to a preparation method of a treatment material, in particular to a preparation method of a self-foaming porous composite bone repair bracket. Background technique [0002] Porous scaffolds play an important role in bone tissue engineering as material and structural templates. Appropriate biomimetic pore structure is the key to the optimal osteogenesis performance of porous scaffolds. Although porous scaffold materials have made great progress in the research and application of bone tissue engineering, there are common problems such as the mismatch between the mechanical properties and degradation performance of scaffold materials and natural bone regeneration, uneven pores, and poor connectivity, which make it difficult for cells and tissues to Penetration grows into the inside of the stent and only grows on the periphery of the stent. At the same time, material transport is hindered, which is not conducive to the renewal of loc...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/12A61L27/18A61L27/54A61L27/58
CPCA61L27/12A61L27/18A61L27/56A61L2430/02
Inventor 李吉东李根左奕李玉宝邹琴张利
Owner SICHUAN UNIV
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