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Preparation method and application of titanium dioxide-graphene oxide composite material modified by hyaluronic acid of antitumor drug nanometer layer

A technology of hyaluronic acid modification and nanocomposite materials, which is applied in the field of medicine and can solve unseen problems

Inactive Publication Date: 2015-12-30
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no public report on the hyaluronic acid-modified titanium dioxide-graphene oxide composite material with anti-tumor drug nano-layer and its application

Method used

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  • Preparation method and application of titanium dioxide-graphene oxide composite material modified by hyaluronic acid of antitumor drug nanometer layer
  • Preparation method and application of titanium dioxide-graphene oxide composite material modified by hyaluronic acid of antitumor drug nanometer layer

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Embodiment 1

[0020] In concrete implementation, the present invention can be realized by the following steps:

[0021] (1) Synthesis of titanium dioxide-graphene oxide (Ti-GO) nanocomposites: Weigh 0.5g of titanium sulfate, dissolve it in 20ml of water, add 160mg of graphene oxide, stir for 4h, then add 0.524g of hexadecyltrimethyl Ammonium bromide (CTAB), stirred for 12 hours, then transferred to a reaction kettle, reacted in a water bath at 120-150°C for 48-96 hours, centrifuged, and removed water to obtain a crude product, which was washed with deionized water and absolute ethanol 5 times, suction filtration after ion exchange to obtain a filter cake, put the filter cake in a vacuum drying oven at 60-80°C for 12-24h, and calcinate at 350-450°C for 2-4h to obtain titanium dioxide-graphene oxide (Ti-GO ) nanocomposite materials;

[0022] (2) Synthesis of ammoniated hyaluronic acid (HA): Weigh 150mg of hyaluronic acid (HA) into 12.5ml of solvent, dissolve in an oil bath at 50°C, cool to r...

Embodiment 2

[0026] In specific implementation, the present invention can also be realized by the following steps:

[0027] (1) Synthesis of titanium dioxide-graphene oxide (Ti-GO) nanocomposites: Weigh 0.25g of titanium sulfate, dissolve it in 10ml of water, add 80mg of graphene oxide, stir for 4h, then add 0.262g of hexadecyltrimethyl Ammonium bromide (CTAB), stirred for 12 hours, then transferred to a reaction kettle, reacted in a water bath at 120-150°C for 48-96 hours, centrifuged, and removed water to obtain a crude product, which was washed with deionized water and absolute ethanol 5 times, suction filtration after ion exchange to obtain a filter cake, put the filter cake in a vacuum drying oven at 60-80°C for 12-24h, and calcinate at 350-450°C for 2-4h to obtain titanium dioxide-graphene oxide (Ti-GO ) nanocomposite materials;

[0028] (2) Synthesis of ammoniated hyaluronic acid (HA): Weigh 100mg of hyaluronic acid (HA) into 5ml of solvent, dissolve in an oil bath at 50°C, cool to...

Embodiment 3

[0032] The present invention can also be realized by the following steps in concrete implementation:

[0033] (1) Synthesis of titanium dioxide-graphene oxide (Ti-GO) nanocomposite: Weigh 0.75g of titanium sulfate, dissolve it in 30ml of water, add 80-240mg of graphene oxide, stir for 4h, then add 0.262-0.786g of hexadecane Trimethylammonium bromide (CTAB), stirred for 12 hours, then transferred to a reaction kettle, reacted in a water bath at 120-150°C for 48-96 hours, centrifuged, and removed water to obtain a crude product, which was washed with deionized water and anhydrous Wash with water and ethanol for 5 times, filter with suction after ion exchange to obtain a filter cake, put the filter cake in a vacuum drying oven at 60-80°C for 12-24h, and calcinate at 350-450°C for 2-4h to obtain titanium dioxide-graphene oxide (Ti-GO) nanocomposites;

[0034] (2) Synthesis of ammoniated hyaluronic acid (HA): Weigh 200mg of hyaluronic acid (HA) into 20ml of solvent, dissolve in an...

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Abstract

The invention relates to a preparation method and application of a titanium dioxide-graphene oxide composite material modified by hyaluronic acid of an antitumor drug nanometer layer and effectively solves the problem of preparing the Ti-GO nanometer composite material which has thermal therapy and photodynamic therapy activity, tumor cell targeting property and good biocompatibility and is modified by HA and the problem of achieving pharmacy of anti-tumor treatment. The method includes the steps that the titanium dioxide-graphene oxide composite material is synthesized through a hydrothermal method, then the hyaluronic acid is in chemical connection with the titanium dioxide-graphene oxide composite material through an amido bond with thionyldialkylamine as a connection arm, and the titanium dioxide-graphene oxide composite material modified by the hyaluronic acid of the nanometer layer is formed in a water medium. The titanium dioxide-graphene oxide composite material modified by the hyaluronic acid of the antitumor drug nanometer layer can be used for tumor near infrared imaging diagnosis and tumor treatment at the same time, and application of the titanium dioxide-graphene oxide composite material to preparation of drugs for tumor near infrared imaging diagnosis and tumor treatment is achieved.

Description

technical field [0001] The invention relates to medicine, in particular to a preparation method and application of a hyaluronic acid-modified titanium dioxide-graphene oxide composite material (Ti-GO-HA) with an antitumor drug nano-layer. Background technique [0002] Currently, chemotherapy, radiotherapy and surgery are commonly used clinically to treat cancer. Chemotherapy drugs are widely distributed throughout the body, have large toxic and side effects, and are prone to recurrence. Radiation therapy takes advantage of the radiation sensitivity of cancer cells, using high-energy electromagnetic radiation to kill cancer cells and shrink tumors, but normal tissues will also be damaged by radiation during clinical treatment. Although surgery can remove tumor lesions, it is traumatic to the human body, and the curative effect is often poor because the cancer cells have spread. Therefore, the further development of new technologies and methods for cancer treatment with high...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K41/00A61K49/00A61P35/00
Inventor 张红岭张慧娟张振中陈倩倩张晓戈
Owner ZHENGZHOU UNIV