Multifunctional nano material in metal organic framework mesoporous structure and preparation method thereof

A metal-organic framework and mesoporous structure technology, applied in the field of preparation of nanocomposite materials, can solve the problems of differential thermal stability and chemical stability, and achieve high stability, simple and easy preparation process, easy production and promotion. Effect

Active Publication Date: 2016-01-06
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they all have various limitations, such as poor thermal and chemical stability, rapid decomposition in the immune system, etc.

Method used

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  • Multifunctional nano material in metal organic framework mesoporous structure and preparation method thereof
  • Multifunctional nano material in metal organic framework mesoporous structure and preparation method thereof
  • Multifunctional nano material in metal organic framework mesoporous structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment ( 1

[0022] (1) Synthesis of monodisperse magnetic colloid clusters by high temperature pyrolysis process. The specific scheme is as follows: First, the key NaOH / DEG stock solution in the synthesis process, 2.5mmol / mLNaOH was dissolved in 8mL diethylene glycol (DEG), the solution was heated to 120°C and maintained for 1h under stirring, then cooled to 70°C and waited. use. Then 0.576g polyacrylic acid (PAA) and 1.08gFeCl 3 After dissolving in 30mL DEG to form a transparent solution, it was heated to 220°C with stirring in the presence of nitrogen. When the color of the mixture in the flask turned light yellow, quickly inject 2mL of NaOH / DEG mixed solution under stirring. Keep at 220°C for 2h and then cool to room temperature. The final product was washed three times with distilled water and absolute ethanol, and finally dispersed into 10 mL of deionized water to obtain magnetic colloid clusters with a diameter of about 10 nm.

[0023] (2) The reaction of aqueous solution at room...

Embodiment ( 2

[0026] (1) Synthesis of monodisperse magnetic colloid clusters by high temperature pyrolysis process. The specific scheme is as follows: First, the key NaOH / DEG stock solution in the synthesis process, 2.5mmol / mLNaOH was dissolved in 6mL of diethylene glycol (DEG), the solution was heated to 120°C and maintained for 1h under stirring, then cooled to 70°C for use. Then 0.5g polyacrylic acid (PAA) and 0.9gFeCl 3 After being dissolved in 28mLDEG to form a transparent solution, it was heated to 220°C with stirring in the presence of nitrogen. When the color of the mixture in the flask turned light yellow, 2.5mLNaOH / DEG mixed solution was quickly injected into it under stirring, It was kept at 220° C. for 2 h and then cooled to room temperature. The final product was washed three times with distilled water and absolute ethanol, and finally dispersed into 10 mL of deionized water to obtain magnetic colloid clusters with a diameter of about 30 nm.

[0027] (2) The reaction of aque...

Embodiment ( 3

[0030] (1) Synthesis of monodisperse magnetic colloid clusters by high temperature pyrolysis process. The specific scheme is as follows: First, the key NaOH / DEG stock solution in the synthesis process, 2.5mmol / mLNaOH was dissolved in 10mL of diethylene glycol (DEG), the solution was heated to 120°C and kept under stirring for 1h, then cooled to 70°C for use. Then 0.6g polyacrylic acid (PAA) and 1.5gFeCl 3 After being dissolved in 34mLDEG to form a transparent solution, it was heated to 220°C with stirring in the presence of nitrogen, and when the color of the mixture in the flask turned light yellow, it was quickly injected with 3.5mLNaOH / DEG mixed solution under stirring, It was kept at 220° C. for 2 h and then cooled to room temperature. The final product was washed three times with distilled water and absolute ethanol, and finally dispersed into 10 mL of deionized water to obtain magnetic colloidal clusters with a particle size of about 70 nm.

[0031] (2) The reaction o...

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Abstract

The invention provides a multifunctional nano material in a metal organic framework mesoporous structure and a preparation method thereof. The MOFs mesoporous nano material with high stability, good dispersibility and excellent hydrophilicity is prepared through a high-temperature pyrolysis method and an electrostatic adsorption method, a large surface area is provided for introduction of a large quantity of functional molecular groups, and a large aperture is provided for absorbing and packaging biological molecules. Fe3O4 serves as a photo-thermal reagent and a target reagent, and through responses to external magnetic fields and infrared light sources, targeting and photo-thermal treatment of cancer cells are achieved. By means of Au25 serving as a photosensitizer, Au25 can be directly photosensitized through infrared light, a large amount of singlet oxygen is generated, and accordingly the anti-cancer function is achieved. By changing the mass of reactants, the multifunctional nano composite materials in different sizes and in a MOFs structure can be synthesized.

Description

technical field [0001] The invention relates to a nanocomposite material. The invention also relates to a preparation method of the nanocomposite material. Background technique [0002] Drug carrier is one of the most important and attractive research fields, and carrier is the most critical for controlling drug storage capacity and its functional effect. In the last decade, this research has been greatly improved, and in the drug carrier system, a large number of organic systems have been investigated as drug carrier candidates, such as micelles, liposomes and polymers. However, they all have various limitations, such as poor thermal and chemical stability, rapid breakdown in the immune system, etc. In contrast, inorganic-organic hybrid mesoporous materials have good biocompatibility, stable selectivity and non-toxicity, so they have great potential as adjuvants in pharmaceutical technology. [0003] As we all know, mesoporous materials are one of the most important carr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/24A61K47/04A61K41/00A61P35/00
Inventor 杨飘萍杨丹盖世丽杨桂欣毕惠婷徐加廷冯莉莉
Owner HARBIN ENG UNIV
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