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Antiepileptic drug combination containing 2-diphenol

A biphenol and drug technology, applied in the field of drug combination, can solve the problems of serious adverse reactions, toxic side effects, dependence and addiction, etc.

Active Publication Date: 2016-01-20
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, both benzodiazepines and barbiturates have serious adverse reactions and side effects (such as: diazepam has central system toxicity, which can produce dependence and addiction; Sodium has central and respiratory system toxicity), therefore, how to maintain and improve the curative effect of antiepileptic drugs while reducing its dosage so as to reduce adverse reactions and toxic and side effects is the focus of the present invention's research

Method used

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  • Antiepileptic drug combination containing 2-diphenol
  • Antiepileptic drug combination containing 2-diphenol
  • Antiepileptic drug combination containing 2-diphenol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Embodiment 1 Diazepam 4mg, biphenol 32mg compound tablet (in 1000 pieces)

[0094] Party:

[0095]

[0096] Coating prescription:

[0097] Opadry Coating Powder 4g

[0098] Purified water 45g

[0099] Preparation:

[0100] (1) Weigh the prescribed amount of diazepam and diphenol, pulverize them through an 80-mesh sieve, and mix them uniformly by using the method of equal increments.

[0101] (2) Weigh the lactose, starch, pregelatinized starch and calcium stearate of the prescribed amount, grind them through a 60-mesh sieve, and mix them evenly.

[0102] (3) Mix (1) and (2) uniformly to obtain an intermediate.

[0103] (4) Check the intermediate content, calculate the tablet weight, compress the tablet, and control the tablet hardness to be 7kg.

[0104] (5) Weigh the purified water according to the prescription ratio, slowly add the prescribed amount of Opadry coating powder under stirring condition, and stir thoroughly for 45 minutes.

[0105] (6) Place the ...

Embodiment 2

[0106] Embodiment 2 Diazepam 4mg, biphenol 32mg compound capsule (in 1000 grains)

[0107] Party:

[0108]

[0109] Preparation:

[0110] (1), raw materials and auxiliary materials are respectively passed through 80 mesh sieves, and set aside.

[0111] (2), get povidone K30, sodium lauryl sulfate, add warm water and dissolve to 50ml, as adhesive;

[0112] (3), take by weighing biphenol, diazepam, microcrystalline cellulose, polyvinylpolypyrrolidone, mix uniformly with equal increment method, add binding agent and make soft material, 18 mesh sieves granulate, at 80 Dry at ℃.

[0113] (4), after the granules are dried, sieve the granules with 20 meshes, then add magnesium stearate, and mix well.

[0114] (5), calculate intermediate content, calculate loading capacity.

[0115] (6), fill with No. 3 capsules.

Embodiment 3

[0116] Embodiment 3 Diazepam 4mg, biphenol 32mg compound injection (1000ml meter)

[0117] Party:

[0118]

[0119]

[0120] Preparation:

[0121] Mix propylene glycol, ethanol and benzyl alcohol solutions in a preparation container to dissolve biphenol and diazepam in the above mixed solution, slowly add water for injection to about 800ml, and adjust the pH to 6.5-7.0. Add sufficient water for injection, shake well, and filter. Nitrogen was passed through the solution, and the potting was performed under a nitrogen flow, and sterilized at 121° C. for 15 minutes.

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Abstract

The invention provides an antiepileptic drug combination containing 2-diphenol. The antiepileptic drug combination is characterized by comprising 2-diphenol or medicinal salt and benzodiazepines drugs or barbiturates drugs and can further comprise at least one freely-selected medicinal carrier. Through combined application of 2-diphenol and benzodiazepines drugs or the barbiturates drugs, an antiepileptic drug effect synergistic effect can be achieved, the usage quantity of the benzodiazepines drugs or barbiturates drugs can be reduced to achieve the same or a better therapy effect, and then drug toxicity is reduced.

Description

technical field [0001] The invention relates to a drug combination, in particular to an antiepileptic drug combination containing biphenol. Background technique [0002] Epilepsy is a neurological disease, which is a transient brain dysfunction caused by sudden abnormal discharge due to brain neuron lesions or damage. Epileptic seizures can lead to selective damage and even death of brain neurons, which can lead to plastic changes in brain structure and function such as glial cell proliferation, mossy fiber sprouting, and synaptic reconstruction. aggravated. About 1% of the world's population suffers from epilepsy, with increased incidence among infants and the elderly. The number of epilepsy patients in my country has exceeded 9 million and is increasing. [0003] The pathogenesis of epilepsy is very complex, and the essence of its seizures is the excessive synchronous discharge of brain neurons. The abnormal discharge of neurons is closely related to neurotransmitters,...

Claims

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Application Information

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IPC IPC(8): A61K31/5513A61K31/515A61P25/08A61K31/05
Inventor 安龙王汝涛王惟娇
Owner XIAN LIBANG PHARMA