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Method for preparing chlorophyll sodium copper from mulberry leaves

A technology of sodium copper chlorophyllin and mulberry leaves, applied in the direction of organic chemistry, can solve the problems of shortening the reaction time, decolorization of the alcohol extract, etc., and achieve the effects of shortening the reaction time, easy separation, and good commercial prospects

Active Publication Date: 2016-01-27
上海天伟质量检测技术服务有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention solves the decolorization problem of the alcohol extraction solution in the comprehensive utilization of mulberry leaf resources (70% ethanol solution is often used for the extraction of mulberry leaf medicinal materials, and macromolecular alcohol-soluble substances such as pigments and proteins are often brought together when the active ingredients are extracted) out), using the waste in the process to make copper chlorophyllin sodium salt product; the present invention uses the "multipolar organic solvent-alkaline water" mixed saponification system to shorten the reaction time, easy to separate the target product, and has good commercial prospects, suitable for large-scale industrial production

Method used

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  • Method for preparing chlorophyll sodium copper from mulberry leaves
  • Method for preparing chlorophyll sodium copper from mulberry leaves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Dry mulberry leaf powder is extracted by adding 70v / v% ethanol at a mass ratio of 1:10 to obtain an alcohol extract, which is concentrated to 1 / 15 of the original volume, and centrifuged at 4000rpm for 3 minutes in a low-speed centrifuge to obtain the upper pigment paste Slurry and lower liquid, wherein the lower liquid accounts for 80% of the total volume;

[0057] (2) The lower layer liquid is extracted twice with petroleum ether at a volume ratio of 1:1, and the liquid is separated to obtain the depigmented mulberry leaf alcohol extract (for other purposes), and petroleum ether extract;

[0058] (3) The petroleum ether extract is at a temperature of 65°C and a vacuum of 0.08MPa, and the petroleum ether is recovered by rotary evaporation to obtain a substance after the petroleum ether is recovered, which is combined with the pigment paste obtained by centrifugation, and the mixed pigment paste obtained at this time is The solid content is 10wt%;

[0059] (4) Add ...

Embodiment 2

[0069] (1) Dry mulberry leaf powder is extracted by adding 70v / v% ethanol at a mass ratio of 1:15 to obtain an alcohol extract, which is concentrated to 1 / 20 of the original volume, and centrifuged at 3000rpm for 3 minutes in a low-speed centrifuge to obtain the upper pigment paste Slurry and lower liquid, wherein the lower liquid accounts for 90% of the total volume;

[0070] (2) The lower liquid was extracted 3 times with petroleum ether at a volume ratio of 2:1, and the liquid was separated to obtain the depigmented mulberry leaf alcohol extract (for other purposes), and petroleum ether extract;

[0071] (3) The petroleum ether extract is at a temperature of 65°C and a vacuum of 0.08MPa, and the petroleum ether is recovered by rotary evaporation to obtain a substance after the petroleum ether is recovered, which is combined with the pigment paste obtained by centrifugation, and the mixed pigment paste obtained at this time is The solid content is 12wt%;

[0072] (4) Add pe...

Embodiment 3

[0082] (1) Dry mulberry leaf powder is extracted by adding 80v / v% ethanol at a mass ratio of 1:20 to obtain an alcohol extract. The alcohol extract is concentrated to 1 / 15 of the original volume, and centrifuged at 100rpm in a low-speed centrifuge for 4 minutes to obtain the upper pigment paste Slurry and lower liquid, wherein the lower liquid accounts for 85% of the total volume;

[0083] (2) The lower liquid was extracted 4 times with petroleum ether at a volume ratio of 1:1, and the liquid was separated to obtain the depigmented mulberry leaf alcohol extract (for other purposes), and petroleum ether extract;

[0084] (3) The petroleum ether extract is at a temperature of 65°C and a vacuum of 0.08MPa, and the petroleum ether is recovered by rotary evaporation to obtain a substance after the petroleum ether is recovered, which is combined with the pigment paste obtained by centrifugation, and the mixed pigment paste obtained at this time is The solid content rate is 15wt%;

...

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Abstract

The invention relates to a method for preparing chlorophyll sodium copper from mulberry leaves. The method comprises the steps that part water is removed by conducting centrifugalization on a mulberry leaf alcohol extraction concentrated solution, pigment paste is obtained, saponification is conducted through a multi-polarized organic solvent-alkaline water mixed system, copper substitution reaction is conducted through heating, washing and refining are conducted on multi-polarized organic solvent, ethanol and sodium hydroxide are salified and dissolved through deionized water, the pH value is adjusted, decompression and drying are conducted, and a chlorophyll sodium copper product is obtained. The absorbance value E (1 cm, 1%) is larger than or equal to 250, the absorbance ratio ranges from 3.3 to 3.6, and the content is larger than 70 percent. According to the method for preparing the chlorophyll sodium copper from the mulberry leaves, the decoloration problem in mulberry leaf resource comprehensive utilization is resolved, the chlorophyll sodium copper is prepared by means of produced waste, and the waste is turned into treasure; the reaction time is shortened by conducting saponification through a mixed system, target product separation is easy, and the yield is increased; refining is conducted on prepared crude copper chlorophyll acid by means of different polar solvents, and the purity is improved. The method for preparing the chlorophyll sodium copper from the mulberry leaves has good commercial prospect and is suitable for large-scale industrial production of plant extraction process and the chlorophyll sodium copper.

Description

technical field [0001] The invention belongs to the technical field of extracting components of mulberry leaves, and relates to a method for preparing sodium copper chlorophyllin from mulberry leaves. Background technique [0002] Mulberry leaf is the dry leaf of Moraceae plant mulberry (Morusalba L.), which is produced in most areas of my country and can be collected all year round; its sources are widely available and cheap. It tastes bitter, sweet, and cold in nature. According to the "Compendium of Materia Medica": "The spirit of the mulberry star is also known as the article eaten by cicadas, and the old man who eats it is a child." It has a good reputation for lowering blood pressure, lowering blood fat, lowering cholesterol, antithrombosis and anti-atherosclerosis, anti-fatigue and anti-aging, laxative, and weight loss. It is a "medicine and food homologous" plant confirmed by the Ministry of Health. Because of its unique functional ingredients such as mulberry leaf ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22
CPCC07D487/22
Inventor 李森原王济强何秋旻朱桂秀陈莹
Owner 上海天伟质量检测技术服务有限公司
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